Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis.

Significant progress is made in the treatment of metastatic colorectal cancer (mCRC) patients, however, therapeutic options remain limited for patients with mCRC. In recent years, traditional Chinese medicine (TCM) has gained significant attention. Among these, Huangqin Houpo decoction has demonstrated efficacy in mCRC treatment.

Tuning Absorption State and Intermolecular Potential of Organic Semiconductors for Narrowband Ultraviolet Photodetection.

Narrowband response of organic semiconductors determines the band selectivity and anti-interference of the organic photodetectors, which are pursued for a long time but have not yet been resolved in the UV band. Herein, a feasible strategy is developed to realize narrowband UV response by tuning the absorption state and intermolecular potential of organic semiconductors. The as-designed non-Donor-Acceptor molecule, 2,5-diphenylthieno[3,2-b]thiophene (2,5-DPTT), exhibits narrowband absorption by fully suppressing the charge transfer state absorption.

BRA-YOLOv7: improvements on large leaf disease object detection using FasterNet and dual-level routing attention in YOLOv7.

Tea leaf diseases are significant causes of reduced quality and yield in tea production. In the Yunnan region, where the climate is suitable for tea cultivation, tea leaf diseases are small, scattered, and vary in scale, making their detection challenging due to complex backgrounds and issues such as occlusion, overlap, and lighting variations. Existing object detection models often struggle to achieve high accuracy in detecting tea leaf diseases.

Molecular composition difference of electron donating moieties between natural organic matter and effluent organic matter probed by chlorine dioxide.

Lignin- and tannin-like phenolic compounds are shown to be the major compositions of electron donating moieties (EDM) of aquatic natural organic matter (NOM). However, little is known about the compositions of EDMs within effluent organic matter (EfOM). In the present study, chlorine dioxide (ClO) was used as a selectively oxidative probe to investigate the difference in the molecular composition of EDM between NOM and EfOM due to its high selectivity towards electron-rich compounds.

Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein.

Cow milk protein allergy (CMPA) is the most common food allergy in infants. Currently, hypoallergenic infant formulas on the market are mainly divided into extensively hydrolyzed whey protein formulas and extensively hydrolyzed casein formulas. There are few extensively hydrolyzed infant formulas (EHFs) with a similar protein composition to breast milk.

Honokiol enhances the sensitivity of cetuximab in KRAS mutant colorectal cancer through destroying SNX3-retromer complex.

: the proto-oncogene is frequently mutated in colorectal cancer (CRC), leading to inherent resistance against monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), such as cetuximab. Therefore, addressing the primary resistance and expanding the indications for target therapy have become critical challenges. : the screening of a natural product library against KRAS mutant CRC cells was conducted, leading to the discovery of a small molecule compound that sensitive to the KRAS mutation site.

CR-YOLOv9: Improved YOLOv9 Multi-Stage Strawberry Fruit Maturity Detection Application Integrated with CRNET.

Strawberries are a commonly used agricultural product in the food industry. In the traditional production model, labor costs are high, and extensive picking techniques can result in food safety issues, like poor taste and fruit rot. In response to the existing challenges of low detection accuracy and slow detection speed in the assessment of strawberry fruit maturity in orchards, a CR-YOLOv9 multi-stage method for strawberry fruit maturity detection was introduced.

Assessing spatiotemporal population density dynamics from 2000 to 2020 in megacities using urban and rural morphologies.

Rapid urbanization has resulted in the substantial population growth in metropolitan areas. However, existing research on population change of the cities predominantly draws on grid statistical data at the administrative level, overlooking the intra-urban variegation of population change. Particularly, there is a lack of attention given to the spatio-temporal change of population across different urban forms and functions.

Does the use of chlorantraniliprole during queen development adversely impact health and viability?

The queen is the sole reproductive individual and the maturing brood replenishes the shorter-lived worker bees. Production of many crops relies on both pesticides and bee pollination to improve crop quantity and quality. Despite the certain knowledge on chemical pesticides caused damage to worker bee physiology and behavior, our understanding of the relationship between honeybee queen development and chemical pesticides remains weak.

Detection Model of Tea Disease Severity under Low Light Intensity Based on YOLOv8 and EnlightenGAN.

In response to the challenge of low recognition rates for similar phenotypic symptoms of tea diseases in low-light environments and the difficulty in detecting small lesions, a novel adaptive method for tea disease severity detection is proposed. This method integrates an image enhancement algorithm based on an improved EnlightenGAN network and an enhanced version of YOLO v8. The approach involves first enhancing the EnlightenGAN network through non-paired training on low-light-intensity images of various tea diseases, guiding the generation of high-quality disease images.

Topology and giant circular dichroism of enantiomorphic Kagome bands in a designed covalent organic framework.

Covalent organic frameworks (COFs) are an emerging class of crystalline organic materials that have shown potential to be a new physical platform. In this work, a designed COF named AB-COF, which has novel enantiomorphic Kagome bands, is proposed and a feasible route to synthesize it is given. a combination of first-principles calculations and tight-binding analysis, we investigate the electronic structures and the phase interference of the COF.

YOLOv8-RMDA: Lightweight YOLOv8 Network for Early Detection of Small Target Diseases in Tea.

In order to efficiently identify early tea diseases, an improved YOLOv8 lesion detection method is proposed to address the challenges posed by the complex background of tea diseases, difficulty in detecting small lesions, and low recognition rate of similar phenotypic symptoms. This method focuses on detecting tea leaf blight, tea white spot, tea sooty leaf disease, and tea ring spot as the research objects. This paper presents an enhancement to the YOLOv8 network framework by introducing the Receptive Field Concentration-Based Attention Module (RFCBAM) into the backbone network to replace C2f, thereby improving feature extraction capabilities.

Protocol to synthesize sequence-controlled glycooligomers for tumor targeting in mice.

Due to the higher and more rapid consumption of carbohydrates by cancer cells compared to normal cells, carbohydrates can be effectively employed as a targeted therapeutic strategy for tumor treatment. Here, we present a protocol for synthesizing sequence-controlled glycooligomers using both solution-phase and solid-phase systems. We outline detailed procedures for evaluating the safety and tumor-targeting properties of the sequence-controlled glycooligomers in vivo.

Active metabolites combination therapies: towards the next paradigm for more efficient and more scientific Chinese medicine.

Traditional Chinese medicine (TCM) formulae have been studied extensively in various human diseases and have proven to be effective due to their multi-component, multi-target advantage. However, its active metabolites are not clear and the specific mechanisms are not well established, which limits its scientific application. Recently, combination therapies are attracting increasing attention from the scientific community in the past few years and are considered as the next paradigm in drug discovery.

Functional analysis of three odorant receptors in Plutella xylostella response to repellent activity of 2,3-dimethyl-6-(1-hydroxy)-pyrazine.

Plutella xylostella is an important pest showing resistance to various chemical pesticides, development of botanical pesticides is an effective strategy to resolve above problem and decrease utilization of chemical pesticides. Previous study showed that 2,3-dimethyl-6-(1-hydroxy)-pyrazine has significant repellent activity to P. xylostella adult which mainly effect to the olfactory system, however the molecular targets and mechanism are still unclear.

Identification and functional characterization of two antenna-specifc odorant-binding proteins in Plutella xylostella response to 2,3-dimethyl-6-(1-hydroxy)-pyrazine.

Plutella xylostella is an important cruciferous crop pest with a serious resistance to multiple insecticides, a novel natural compound, 2,3-dimethyl-6-(1-hydroxy)-pyrazine were isolated, that showed significant repellent activity against P. xylostella with olfactory system as a potential target. Eight odorant-binding proteins (OBPs) were determined as candidate target genes using RT-qPCR (Quantitative reverse transcription PCR), most of them were clustered with OBPs from Spodoptera frugiperda.

Ecological Toxicity of Cyantraniliprole against : Histopathology, Oxidative Stress, and Intestinal Microbiota.

Cyantraniliprole is a novel insecticide recently introduced for rice pest control that may cause potential threats to the red swamp crayfish () in rice-crayfish coculture systems. In this study, we investigated the acute toxicity of cyantraniliprole against with a LC value of 149.77 mg/L (96 h), first.

A novel ensemble learning method for crop leaf disease recognition.

Deep learning models have been widely applied in the field of crop disease recognition. There are various types of crops and diseases, each potentially possessing distinct and effective features. This brings a great challenge to the generalization performance of recognition models and makes it very difficult to build a unified model capable of achieving optimal recognition performance on all kinds of crops and diseases.

Enantiomorphic kagome bands in a two-dimensional covalent organic framework with non-trivial magnetic and topological properties.

The kagome lattice is one of the most intriguing topics to study. It has a frustrated flat band touching a set of Dirac bands and can possess various promising properties, such as ferromagnetism, superconductivity, and a non-trivial topology. Covalent organic frameworks (COFs) are a rare type of inorganic material, however, they can provide a platform for generating certain required lattices.

Residue Behavior of Chiral Fungicide Prothioconazole and Its Major Chiral Metabolite in Flour Product Processing.

This study systematically investigates the stereoselective metabolism and residue behavior of chiral pesticide prothioconazole enantiomers during the steaming, baking, and frying of steamed buns, bread, and deep-fried dough sticks. The results show that steaming, baking, and frying can significantly promote the degradation of the prothioconazole enantiomers. In low- and high-concentration treatments, the degradation rates of prothioconazole enantiomers were over 96.

Effect of novel botanical synergist on the effectiveness and residue behavior of prothioconazole in wheat field.

Fusarium head blight (FHB) is a critical fungal disease causes serious grain yield losses and mycotoxin contaminations. Currently, utilization of chemical fungicides is the main control method which has led to serious resistance. Development of novel synergist is an important strategy to reduce the usage of chemical fungicides and postpone the development of resistance, while natural components are interesting resources.

Risk assessment of honeybee larvae exposure to pyrethroid insecticides in beebread and honey.

Honeybee is an essential pollinator to crops, evaluation to the risk assessment of honeybee larvae exposure to pesticides residue in the bee bread and honey is an important strategy to protect the bee colony due to the mixture of these two matrices is main food for 3-day-old honeybee larvae. In this study, a continuous survey to the residue of five pyrethroid insecticides in bee bread and honey between 2018 and 2020 from 17 major cultivation provinces which can be determined as Northeast, Northwest, Eastern, Central, Southwest, and Southern of China, there was at least one type II pyrethroid insecticide was detected in 54.7 % of the bee bread samples and 43.