Publications by authors named "Quan Duy Vo"
Induced pluripotent stem cell (iPSC)-derived biological pacemakers have emerged as an alternative to traditional electronic pacemakers for managing cardiac arrhythmias. While effective, electronic pacemakers face challenges such as device failure, lead complications, and surgical risks, particularly in children. iPSC-derived pacemakers offer a promising solution by mimicking the sinoatrial node's natural pacemaking function, providing a more physiological approach to rhythm control.
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- Primary percutaneous coronary intervention (PCI) can cause microvascular embolism by dislodging atherosclerotic debris, but thrombus aspiration (TA) before stenting in STEMI patients has shown benefits like reduced mortality and improved cardiac function.
- A study involving 92 STEMI patients at Nguyen Tri Phuong Hospital revealed that those who underwent TA had better TIMI and TMP flow grades and higher ST-segment normalization rates, although major adverse cardiac events (MACEs) at 30 days and 12 months were similar between TA and non-TA groups.
- The findings suggest that while TA can improve myocardial perfusion metrics in STEMI patients, it does not increase the risk of adverse outcomes, highlighting its potential role in enhancing coronary care
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- *Two cases of superior mesenteric artery (SMA) thrombosis in COVID-19 patients were reported, confirmed by CT scans, without bowel necrosis being present.
- *Endovascular intervention with stent placement was successful, and both patients remained symptom-free after 6 months of treatment.*
Heart failure (HF) causes over 266,400 deaths annually. Despite treatment advancements, HF mortality remains high. Induced pluripotent stem cells (iPSCs) offer promising new options.
View Article and Find Full Text PDFBackground: Left main (LM) coronary artery disease (CAD) is a severe condition that can lead to severe outcomes. Treatment options include medication, coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI). Recent advancements in PCI techniques position it as a viable alternative to CABG for LM revascularisation.
View Article and Find Full Text PDFBackground: Stem cell research, particularly in the domain of induced pluripotent stem cell (iPSC) technology, has shown significant progress. The integration of artificial intelligence (AI), especially machine learning (ML) and deep learning (DL), has played a pivotal role in refining iPSC classification, monitoring cell functionality, and conducting genetic analysis. These enhancements are broadening the applications of iPSC technology in disease modelling, drug screening, and regenerative medicine.
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- * A comprehensive meta-analysis of 51 animal studies revealed that iPSC-CM transplantation improved left ventricular ejection fraction by 8.23% and reduced heart tissue fibrosis, with no significant differences in mortality or arrhythmia risks between treated and control groups.
- * The findings suggest that iPSC-CM therapy could be a safe and effective treatment for IHD, but further large-scale randomized controlled trials are needed to confirm its efficacy due to the variations observed in the studies.