Design, Synthesis, and Biological Evaluation of New Oxadiazole Derivatives as Efficient Antihypertension Drugs.

A series of novel oxadiazole derivatives were designed, synthesized, and evaluated for their pharmacological effects. All target compounds were subjected to analysis using H NMR, C NMR, and mass spectrometry. They showed a strong affinity to the AT1 receptor and effectively lowered blood pressure in spontaneously hypertensive rats at a nanomolar level.

Insecticide chlorfenapyr confers induced toxicity in human cells through mitochondria-dependent pathways of apoptosis.

Pesticides are always used in the environment, the unexpected effects of pesticides on the environment and non-target organisms need to be continuously studied. Insecticide chlorfenapyr (Chl) is widely used in agriculture and also recommended for public health use (e.g.

Significant effects of bioavailable heavy metals on antibiotic resistome in paddy soils as revealed by metagenomic analysis.

Heavy metals (HMs) act as a long-term selective pressure for the emergence and maintenance of antibiotic resistance genes (ARGs) in agricultural soils. However, the effects of HMs on ARG distributions in paddy soils and the underlying mechanisms remain unclear. In this study, 74 soil samples were collected from the paddy fields to explore the impact of HMs on ARG profiles.

Single-cell sequencing unveils mitophagy-related prognostic model for triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking hormone receptors and HER2 expression, leading to limited treatment options and poor prognosis. Mitophagy, a selective autophagy process targeting damaged mitochondria, plays a complex role in cancer progression, yet its prognostic significance in TNBC is not well understood.

Methods: This study utilized single-cell RNA sequencing data from the TCGA and GEO databases to identify mitophagy-related genes (MRGs) associated with TNBC.

DNA tetrahedral nanoparticles: Co-delivery of siOTUD6B/DOX against triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options. Recently, the deubiquitinizing enzyme ovarian tumor domain-containing 6B (OTUD6B) has been reported to play a potential role in TNBC progression. Therefore, this study investigates the role and underlying molecular mechanisms of OTUD6B in vitro and xenograft models of TNBC.

A new perspective to understand public response to the Typhoon Doksuri from coastal and inland regions.

Massive amounts of data from social media possess the potential to rapidly identify the primary issues of concern in emergency disaster management. In summer 2023, Super Typhoon Doksuri which was an exceptionally special typhoon disaster that caused severe damage to China's coastal areas and disastrous impacts in inland regions, particularly triggered the most severe rainstorm in Beijing area in over a century. To enhance typhoon hazard reduction in both coastal and interior locations, it is crucial to examine public response to these events.

Mendelian randomization study of childhood asthma and chronic obstructive pulmonary disease in European and East Asian population.

Objective: The present study aimed to explore the potential causal relationship between childhood asthma and chronic obstructive pulmonary disease (COPD) in European and East Asian populations with Mendelian randomization (MR) analysis.

Methods: Based on summary data from genome-wide association studies, single nucleotide polymorphisms (SNPs) associated with childhood asthma were used as instrumental variables. The MR analysis employed the inverse variance weighting, MR-Egger regression and weighted median method to estimate the causal effect between childhood asthma and COPD in European and East Asian populations.

mycotoxins: The major food contaminants.

Mycotoxins, which are secondary metabolites produced by toxicogenic fungi, are natural food toxins that cause acute and chronic adverse reactions in humans and animals. The genus is one of three major genera of mycotoxin-producing fungi. Trichothecenes, fumonisins, and zearalenone are the major mycotoxins that occur worldwide.

Machine learning models predicts risk of proliferative lupus nephritis.

Objective: This study aims to develop and validate machine learning models to predict proliferative lupus nephritis (PLN) occurrence, offering a reliable diagnostic alternative when renal biopsy is not feasible or safe.

Methods: This study retrospectively analyzed clinical and laboratory data from patients diagnosed with SLE and renal involvement who underwent renal biopsy at West China Hospital of Sichuan University between 2011 and 2021. We randomly assigned 70% of the patients to a training cohort and the remaining 30% to a test cohort.

Contamination and Control of Mycotoxins in Grain and Oil Crops.

Mycotoxins are carcinogenic, teratogenic and mutagenic toxic compounds produced by some filamentous fungi, which are extremely harmful to corn, rice, wheat, peanut, soybean, rapeseed and other grain and oil crops, and seriously threaten environmental safety, food safety and human health. With the rapid increase in the global population and the expansion of the main crop planting area, mycotoxin contamination has increased year by year in agricultural products. The current review aimed to summarize the contamination status and harmful effects of major mycotoxins of grain and oil crops and the environmental factors that impact mycotoxin contamination.

Comparing clinical outcomes of hybrid coronary revascularization with open coronary artery bypass in patients with multi-vessels lesions.

Objectives: Hybrid coronary revascularization (HCR) involves the use of minimally invasive direct coronary artery bypass grafting (CABG) to treat the left anterior descending artery (LAD), and percutaneous coronary intervention to treat non-LAD vessels. We reported the results of a comparative analysis between HCR and off-pump CABG sternotomy (OPCABG).

Methods: Data were retrospectively collated from patients who underwent HCR or OPCABG for multivessel coronary artery disease between 2011 and 2022.

Simplified design method for optical imaging systems based on aberration characteristics of optical-digital joint optimization.

With the continuous improvement of imaging performance requirements, the design of imaging systems has become increasingly complex, making it more difficult and expensive to manufacture and test. To overcome these problems, a simplified design framework for imaging systems based on aberration characteristics of optical-digital joint optimization was built in this paper. Specifically, an improved total variation regularization restoration algorithm was proposed, and the difficulty of correction for different monochromatic aberrations was evaluated.

Magnetic susceptibility and R2*-based texture analysis for evaluating liver fibrosis in chronic liver disease.

Purpose: To explore potential feasibility of texture features in magnetic susceptibility and R2* maps for evaluating liver fibrosis.

Methods: Thirty-one patients (median age 46 years; 22 male) with chronic liver disease were prospectively recruited and underwent magnetic resonance imaging (MRI), blood tests, and liver biopsy. Susceptibility and R2* maps were obtained using a 3-dimensional volumetric interpolated breath-hold examination sequence with a 3T MRI scanner.

Spherical aberration-based compensation method for narcissus.

A narcissus-compensation method is proposed based on a mathematical model that connects the spherical aberration and the narcissus-induced temperature difference (NITD). Through non-sequential ray tracing analysis in ZEMAX, we simulate a compact, five-lens, long-wave infrared (LWIR) optical system with NITD as low as 0.7 mK.

Fast Stray Light Performance Evaluation Based on BSDF and Radiative Transfer Theory.

Evaluating the stray light cancellation performance of an optical system is an essential step in the search for superior optical systems. However, the existing evaluation methods, such as the Monte Carlo method and the ray tracing method, suffer from the problems of vast arithmetic and cumbersome processes. In this paper, a method for a rapid stray light performance evaluation model and quantitatively determining high-magnitude stray light outside the field of view are proposed by adopting the radiative transfer theory based on the scattering property of the bidirectional scattering distribution function (BSDF).

Transcriptional plasticity of schizotrophic responds to symptomatic rapeseed and endophytic wheat hosts.

The broad host range of fungi with differential fungal responses leads to either a pathogenic or an endophytic lifestyle in various host plants. Yet, the molecular basis of schizotrophic fungal responses to different plant hosts remains unexplored. Here, we observed a general increase in the gene expression of associated with pathogenicity in symptomatic rapeseed, including small protein secretion, appressorial formation, and oxalic acid toxin production.

[Correlation of mycoplasma genitalium infection with sperm DNA fragmentation in male infertility patients].

Objective: To study the impact of mycoplasma genitalium (Mg) infection on sperm DNA fragmentation in male infertility patients and its clinical significance.

Methods: We performed flow cytometry and routine semen examination for 100 male infertility patients with Mg infection (the case group) and 200 infertile men without Mg infection (the control group). We treated the patients with the antibacterial drug Azithromycin and examined their sperm DNA fragmentation index (DFI) by flow cytometry after treatment.