MFN2-mediated decrease in mitochondria-associated endoplasmic reticulum membranes contributes to sunitinib-induced endothelial dysfunction and hypertension.

Unlabelled: Treatment of cancer patients with tyrosine kinase inhibitors (TKIs) often results in hypertension, but the underlying mechanism remains unclear. This study aimed to examine the role of mitochondrial morphology and function, particularly mitochondria-associated endoplasmic reticulum membranes (MAMs), in sunitinib-induced hypertension.

Methods: Both in vitro and in vivo experiments performed to assesse reactive oxygen species (ROS), nitric oxide (NO), endothelium-dependent vasorelaxation, systemic blood pressure, and mitochondrial function in human umbilical vein endothelial cells (HUVECs) and C57BL/6 mouse aortic endothelial cells, under vehicle or sunitinib treatment condition.

A multi-year campus-level smart meter database.

With the growing need for precise campus electricity management, understanding load patterns is crucial for improving energy efficiency and optimizing energy use. However, detailed electricity load data for campus buildings and their internal equipment is often lacking, hindering research. This paper introduces an energy consumption monitoring dataset from The Hong Kong University of Science and Technology (HKUST) campus in Hong Kong, comprising data from over 1400 meters across more than 20 buildings and collected over two and a half years.

Activation of CO, CS, and COS by α-Diimine-Stabilized Gallylenes.

Several gallylenes [LGaM(THF)] stabilized by an α-diimine ligand (L=[(2,6-iPrCH)NC(Ph)] ; M=Li, n=3, 3-Li; M=Na, n=4, 3-Na; M=K, n=1, 3-K) were prepared, which display diverse reactivities toward carbon dioxide and its sulfurized analogues. The reaction of 3 with CO yielded a trimeric carbonate complex [{LGa(CO)}{μ-K(THF)}] (4) and a dinuclear oxo-carbonate complex [K(THF)][LGa(μ-CO)(μ-O)GaL] (5) in one pot through reductive disproportionation of CO. For CS, two ethenetetrathiolate gallium complexes, [M(Solv)][LGa(μ-CS)GaL] (M=Na, Solv=THF, 6; M=K, Solv=DME, 7), were obtained via reductive coupling of CS.

Nitrogen uptake by Scenedesmus quadricauda and its responses over environmental factors.

Nitrogen is a vital nutrient for the growth of microalgae. Understanding the mechanism of nitrogen uptake by algae plays a crucial role in addressing and mitigating. Harmful algal blooms.

Fairness matters for change: A multilevel study on organizational change fairness, proactive motivation, and change-oriented OCB.

The success of organizational change often hinges on the perception of fairness within a change unit. This group-level organizational change fairness is crucial for enhancing proactive motivation states and fostering positive change-oriented organizational citizenship behavior (OCB). Rooted in the proactive motivation model, this study establishes a comprehensive multilevel framework to investigate the influence of group-level organizational change fairness on employees' change-oriented OCB.

Construction of a new emergency management system for potentially viral/viral municipal solid waste in China: Based on the "Beam-Column Structure" framework model.

Emergency management of municipal solid waste during public health emergencies is crucial for curbing the spread of viruses and controlling environmental pollution. Most existing solid waste management systems, are designed with a top-down approach, covering multiple industries and sectors. However, these systems often fail to effectively manage potentially viral solid waste in household waste, which impedes effective solid waste management during public health emergencies and increases the risk of viral outbreaks.

Reduction of Ketones and Coupling of Ketyls by a Zn-Zn-Bonded Compound.

The α-diimine-ligated Zn-Zn-bonded compound [K(THF)][LZn-ZnL] (, L = [(2,6-PrCH)NC(Me)]) displays diverse reactivities toward a variety of ketones. In the reaction of with benzophenone or 4,4'-di--butylbenzophenone, a multielectron transfer process was observed to give bimetallic (Zn/K) complexes with both ketyl radical fragments and C-C coupled pinacolate moieties (products and ). In contrast, treating with 9-fluorenone only afforded pinacolate complex .

Smart roofs featuring predictive control: An upgrade for mitigating precipitation extreme-induced pluvial floods.

In the face of escalating urban pluvial floods exacerbated by climate change, conventional roof systems fall short of effectively managing precipitation extremes. This paper introduces a smart predictive solution: the Smart Internal Drainage Roof (SIDR) system, which leverages forecasted data to enhance the mitigation of pluvial floods in Central Business District (CBD) areas. Unlike traditional approaches, SIDRs utilize a synergistic combination of Rule-based Control (RBC) and Model Predictive Control (MPC) algorithms, tailored to optimize the operational efficiency of both grey and green roofs.

Activation of cyclopentadiene derivatives by an α-diimine-ligated Mg-Mg-bonded compound.

Heteroleptic, bimetallic (Mg/K) cyclopentadienyl complexes (2-4) were synthesized by the reaction of the Mg-Mg-bonded compound [K(THF)][LMg-MgL] (1, L = [(2,6-iPrCH)NC(CH)]) with cyclopentadiene derivatives, 6,6-dimethylfulvene, 6-(dimethylamino)fulvene, or 1,2,3,4-tetramethyl-1,3-cyclopentadiene. The reactions proceed through diverse pathways, including hydrogen abstraction, C-C coupling, and dehydrogenation, depending on the property of the polyene substrate, thus providing an access to alkali/alkaline earth metal cyclopentadienyl complexes.

Neuroinflammation signatures in dorsal root ganglia following chronic constriction injury.

Neuropathic pain (NP) is a common debilitating chronic pain condition with limited effective therapeutics. Further investigating mechanisms underlying NP is therefore of great importance for discovering more promising therapeutic targets. In the current study, we employed high-throughput RNA sequencing to explore transcriptome profiles of mRNAs and microRNAs in the dorsal root ganglia (DRG) following chronic constriction injury (CCI) and also integrated published datasets for comprehensive analysis.

Source-specific light absorption and radiative effects decreases and indications due to the lockdown.

The 'extreme' emission abatement during the lockdown (from the end of 2019 to the early 2020) provided an experimental period to investigate the corresponding source-specific effects of aerosol. In this study, the variations of source-specific light absorption (b) and direct radiative effect (DRE) were obtained during and after the lockdown period by using the artificial neural network (ANN) and source apportionment environmental receptor model. The results showed that the b decreased for all sources during the two periods.

Vertical measurements of atmospheric CO and CO at the northern foot of the Qinling Mountains in China.

The CO and CO levels in air samples from the northern foot of the Qinling Mountains (Xi'an, China) were determined. In 2021, a hexacopter unmanned aerial vehicle sampled air at different heights, from near-ground to 2000 m. The objectives of this study were to determine vertical characteristics of CO and CO, the sources of different-height CO, and the influence of air mass transport.

Improved eutrophication model with flow velocity-influence function and application for algal bloom control in a reservoir in East China.

Improving hydrodynamic conditions is considered an effective method for facilitating the eutrophication management. However, the effect of hydrodynamic conditions on algal growth has rarely been quantified. In this work, a eutrophication model was developed and flow velocity was introduced into the algae growth kinetic formula to simulate the dynamics of algae growth in a drinking water source reservoir in East China.

[Case Analysis of Heavy Air Pollution Process in Xi'an Using Multi-source Data].

Air pollution continues to be a serious problem in Xi'an. A heavy pollution process and formation mechanism were investigated in Xi'an in January 2019 using multi-source methods (such as material balance and sulfur/nitrogen oxidation rate (SOR/NOR)). The multi-source data included the concentrations of PM, PM, SO, NO, CO, and O; the chemical components of PM; the meteorological records of ground and vertical observations; the atmospheric reanalysis data.

Diverse Reactions of α-Diimine-Ligated Mg -Mg -Bonded Compound with Carbodiimides.

The α-diimine-ligated dimagnesium(I) compound [K(thf) ] [LMg-MgL] (1, L=[(2,6-iPr C H )NC(Me)] ) displays diverse reactivities toward carbodiimides (RN=C=NR) with different R substituents. In the reaction of 1 with Me SiNCNSiMe , one of the easily leaving trimethylsilyl groups is lost to yield the Me SiNCN moiety that either bridges two Mg centers (2) or terminally coordinated (3). In contrast, with the similarly bulky tBuNCNtBu, the carbodiimide inserts into Mg-Mg bond with accompanying C-H activation of a ligand or solvent (products 4 and 5).

White Collar 1 Modulates Oxidative Sensitivity and Virulence by Regulating the HOG1 Pathway in Fusarium asiaticum.

Fusarium asiaticum is an epidemiologically important pathogen of cereal crops in east Asia, accounting for both yield losses and mycotoxin contamination problems in food and feed products. FaWC1, a component of the blue-light receptor White Collar complex (WCC), relies on its transcriptional regulatory zinc finger domain rather than the light-oxygen-voltage domain to regulate pathogenicity of , although the downstream mechanisms remain obscure. In this study, the pathogenicity factors regulated by FaWC1 were analyzed.

Diabetic retinopathy risk prediction in patients with type 2 diabetes mellitus using a nomogram model.

Background: This study aims to develop a diabetic retinopathy (DR) hazard nomogram for a Chinese population of patients with type 2 diabetes mellitus (T2DM).

Methods: We constructed a nomogram model by including data from 213 patients with T2DM between January 2019 and May 2021 in the Affiliated Hospital of Zunyi Medical University. We used basic statistics and biochemical indicator tests to assess the risk of DR in patients with T2DM.

Variations of the urban PM chemical components and corresponding light extinction for three heating seasons in the Guanzhong Plain, China.

In order to investigate the variations of PM (particulate matter with an aerodynamic diameter less than 2.5 μm) chemical components responding to the pollution control strategy and their effect on light extinction (b) in the Guanzhong Plain (GZP), the comparisons of urban atmospheric chemical components during the heating seasons were extensively conducted for three years. The average concentration of PM decreased significantly from 117.

Assessing organic fouling of ultrafiltration membranes using partition coefficients of dissolved organic matter in aqueous two-phase systems.

Organic fouling caused by dissolved organic matter (DOM) is a critical challenge for membrane technologies. In this study, prediction models for the fouling of commercial polyether sulfone (PES) and regenerated cellulose (RC) ultrafiltration membranes by DOM were established based on the hydrophobicity of DOM. The organic fouling behavior of 40 natural water samples collected from Lake Taihu was investigated.

Bone morphogenetic protein-9 maybe an important factor which improves insulin resistance in PCOS.

Background: Polycystic ovary syndrome (PCOS) is closely related to insulin resistance (IR). Bone morphogenetic protein-9 (BMP-9) plays an important role in maintaining glucose homeostasis, but an association between BMP-9 and PCOS has not been reported. Here, we report the changes in BMP-9 and the influence of this protein on IR in PCOS.

Comparison of black carbon, primary and secondary brown carbon light absorption and direct solar absorption at the foothill and summit of Mt. Hua, China.

Atmospheric black carbon (BC), primary and secondary brown carbon (BrC and BrC) are the light-absorbing carbonaceous aerosol components. The vertical changes in the BC and BrC distributions are not generally known. Here, we presented a study of the spectral light absorption properties, direct solar absorption, and potential source areas of BC and BrC at the foothill (375 m a.