Knowledge enhanced bottom-up affordance grounding for robotic interaction.

With the rapid advancement of robotics technology, an increasing number of researchers are exploring the use of natural language as a communication channel between humans and robots. In scenarios where language conditioned manipulation grounding, prevailing methods rely heavily on supervised multimodal deep learning. In this paradigm, robots assimilate knowledge from both language instructions and visual input.

Statistical power analysis and sample size planning for moderated mediation models.

Conditional process models, including moderated mediation models and mediated moderation models, are widely used in behavioral science research. However, few studies have examined approaches to conduct statistical power analysis for such models and there is also a lack of software packages that provide such power analysis functionalities. In this paper, we introduce new simulation-based methods for power analysis of conditional process models with a focus on moderated mediation models.

Development of a Microheater with a Large Heating Area and Low Thermal Stress in the Heating Area.

In this paper, a microheater that can absorb thermal stress and has a large heating area is demonstrated by optimizing the structure and process of the microheater. Four symmetrically distributed elongated support beam structures were machined around the microheater via deep silicon etching. This design efficiently mitigates the deformation of the heated region caused by thermal expansion and enhances the structural stability of the microheater.

Single-institution experience of venetoclax combined with azacitidine in newly diagnosed acute myeloid leukemia patients.

To retrospectively analyze the efficacy and safety of venetoclax combined with azacitidine (VEN + AZA) in the treatment of elderly patients with acute myeloid leukemia. The clinical data for 57 AML patients treated with the VEN + AZA regimen from December 2019 to November 2022 in the Department of Hematology, General Hospital of Tianjin Medical University, were collected. Of the 57 patients included in this study, the mean age of onset was 69.

Design and Analysis of XY Large Travel Micro Stage Based on Secondary Symmetric Lever Amplification.

This study presents a newly developed piezoelectric drive mechanism for the purpose of designing, analyzing, and testing a micro-positioning platform driven by piezoelectric actuators. The platform incorporates a piezoelectric ceramic actuator and a flexible hinge drive and features a symmetrical two-stage lever (STSL) amplification mechanism and a parallelogram output structure. The implementation of this design has led to notable enhancements in the dynamic properties of the platform, thereby eliminating the undesired parasitic displacement of the mechanism.

Systemic subchronic toxicity and comparison of four selenium nutritional supplements by 90-day oral exposure in Sprague-Dawley rats.

To evaluate and compare the safety of four selenium supplements, namely Se-enriched peptides (SeP), yeast selenium (SeY), L-Se-methylselenocysteine (L-SeMc) and sodium selenite (NaSeO), the subchronic toxicity study was designed by 90-day gavage administration in Sprague-Dawley rats. The doses of SeP, SeY, L-SeMc and NaSeO were 0.15, 0.

Extracting Mutant-Affected Protein-Protein Interactions via Gaussian-Enhanced Representation and Contrastive Learning.

Genetic mutations can impact protein-protein interactions (PPIs) in biomedical literature. Automated extraction of PPIs affected by gene mutations from biomedical literature can aid in evaluating the clinical importance of gene variations, which is crucial for the advancement of precision medicine. In this study, a new model called the Gaussian-enhanced representation model (GRM) is introduced for PPI extraction.

A novel PEGylated form of granulocyte colony-stimulating factor, mecapegfilgrastim, for peripheral blood stem cell mobilization in patients with hematologic malignancies.

Background: The Pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) has longer half-life and is given once only, which is more comfortable for patients. We aimed to evaluate the efficacy of mecapegfilgrastim for hematopoietic stem cell (HSC) mobilization in patients with hematologic malignancies and to explore the potential factors related to HSC mobilization.

Methods: A retrospective analysis was performed on patients who underwent HSC mobilization in the hematology department of Mianyang Central Hospital from April 2016 to November 2022.

[Application of Mecapegfilgrastim for Peripheral Blood Hematopoietic Stem Cell Mobilization in Patients With Hematologic Neoplasms and Analysis of Predictors for Poor Mobilization].

Objective: To evaluate the efficacy of applying mecapegfilgrastim for peripheral blood hematopoietic stem cell (PBSC) mobilization in patients with hematologic neoplasms, and to investigate the influencing factors of PBSC collection.

Methods: Patients who underwent PBSC mobilization in the Department of Hematology, Mianyang Central Hospital between April 2016 and May 2022 were retrospectively analyzed. The CD34 cell collection results of two groups, the mecapegfilgrastim group ( =28), or the PEG group, and the recombinant human granulocyte colony-stimulating factor (rhG-CSF) group ( =30), were compared, and the influencing factors of collection failure were analyzed.

FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma.

Anti-CD38 monoclonal antibodies (mAbs), daratumumab, and isatuximab have represented a breakthrough in the treatment of multiple myeloma (MM). Recently, CD38-based mAbs were expected to achieve increasing potential beyond MM, which encouraged us to develop new anti-CD38 mAbs to meet clinical needs. In this study, we developed a novel humanized anti-CD38 antibody, FTL004, which exhibited enhanced pro-apoptotic ability and negligible binding to red blood cells (RBCs).

PM source apportionment identified with total and soluble elements in positive matrix factorization.

Source apportionments of urban aerosols identified with positive matrix factorization (PMF) are sensitive to input variables. So far, total elements were frequently included as effective factors in PMF-based source apportionment. We investigated the advances to involve soluble parts of elements in the source apportionment with four data sets of PM composition observed at a coastal city (Qingdao) in northern China: water-soluble ions plus organic and elemental carbon (IC set), the IC set plus total elements (ICTE set), the IC set plus soluble elements (ICSE set), and the IC set plus both total elements and soluble elements (ICAE set).

Tibetan Medicine Shi-Wei-Gan-Ning-San Alleviates Carbon Tetrachloride-Induced Chronic Liver Injury by Inhibiting TGF-1 in Wistar Rats.

Background: Shi-Wei-Gan-Ning-San (SWGNS) is a classic Tibetan prescription, which has obvious clinical effects in the treatment of viral hepatitis, fatty liver, liver fibrosis, liver cirrhosis, liver cancer, and other liver injuries. However, animal studies and mechanism studies are still lacking. This study aimed to investigate its hepatoprotective efficacy and pharmacological mechanism in animal experiments.

[Research Progress of Short Chain Fatty Acids in the Pathogenesis of Immune Thrombocytopenia--Review].

The gut microbiota is an important part of the human body, and it's also the largest genome in the human body. Recent studies on the gut microbiota have found that it plays an important role in human immune diseases. In recent years, the methods of sequencing gut microbiota has teen improved, thus dysregulation of the gut microbiota is found in many immune diseases, and the most widely studied mechanism is the short-chain fatty acids (SCFA), which is a metabolite of gut microbiota.

[Expression and Significance of PD-1 and ICOS in Patients with Primary Immune Thrombocytopenia].

Objective: To investigate the expression of programmed death receptor-1 (PD-1) and inducible costimulator (ICOS) on the surface of CD8 T cells in peripheral blood of patients with primary immune thrombocytopenia (ITP), and explore the roles of PD-1 and ICOS in the occurrence and development of ITP.

Methods: A total of 28 ITP patients treated in Tianjin Medical University General Hospital from September to December 2020 were selected, including 13 patients with newly diagnosed ITP, 15 patients with chronic ITP, and 22 healthy volunteers were recruited as control group. Flow cytometry was used to detect the expression levels of PD-1 and ICOS, and evaluate their correlation with clinical indicators.

Asthma susceptibility in prenatal nicotine-exposed mice attributed to β-catenin increase during CD4 T cell development.

Cigarette smoke is a common global environmental pollutant. Asthma, the most frequent allergic airway disease, is related to maternal exposure to cigarette smoke. Our previous studies demonstrated that prenatal exposure to nicotine (PNE), the major active product of smoking, impairs fetal thymopoiesis and CD4 T cell development after birth.

A Case Report of Imatinib-induced Acute Heart Failure and Literature Review.

Patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GISTs) or acute lymphoblastic leukemia (ALL) are appropriate candidates for medical treatment using imatinib. Here, we report a case of imatinib-induced acute heart failure in a patient with ALL and retrospectively analyse the adverse reactions of imatinib. The patient was a 45-year man with Ph+ and bcr-abl positive (bcr-abl+) ALL.

Chinese only children and loneliness: Stereotypes and realities.

Popular media has aroused concern that Chinese only children are growing up lonely owing to their lack of sibling interaction Mu et al. (2007). However, little research has been directed at determining whether Chinese adults believe in the only-child-as-lonely stereotype and whether Chinese only children actually suffer more loneliness than their peers with siblings.

Two generation reproduction toxicity study of GmDREB3 gene modified wheat in Wistar rats.

To study reproductive toxicity of gene modified wheat generated by introducing DREB3 (drought response element binding protein 3) gene, Wistar rats of were allocated into 3 groups and fed with DREB3 gene modified wheat mixture diet (GM group), non-gene modified wheat mixture diet (Non-GM group) and AIN-93 diet (Control group) from parental generation (F0) to the second offspring (F2). GM wheat and Non-GM wheat, Jimai22, were both formulated into diets at a ratio of 69.55% according to AIN93 diet for rodent animals.

Dynamic changes and multiplication rate of white blood cell count may direct the timing of cytoreduction chemotherapy during induction treatment in newly diagnosed acute promyelocytic leukemia with low-intermediate risk.

In order to explore the optimal timing for initiating cytoreduction chemotherapy following all-trans retinoic acid plus arsenic trioxide administration, 58 newly diagnosed patients with acute promyelocytic leukemia (APL) with low-intermediate mortality risk were retrospectively analyzed. During induction treatment, white blood cell (WBC) count >4x10/l and multiplication rate of WBC <3 days were defined as rapid WBC multiplication. Patients were divided into two groups: With or without rapid WBC multiplication.

Assessing the changes in childbirth care practices and neonatal outcomes in Western China: pre-comparison and post-comparison study on early essential newborn care interventions.

Objective: To explore the changes in childbirth care practices and health outcomes of newborns after the introduction of early essential newborn care (EENC).

Design: A pre-comparison and post-comparison study.

Setting: The study was conducted in December 2016 and December 2018 in 18 counties in four western provinces of China.

[Expression and Significance of IL-9 and IL-6 in Patients with BCR-ABL- MPN].

Objective: To investigate the expression of IL-9 and IL-6 in patients with BCR-ABL- bone marrow proli- ferative tumor (MPN), and to explore its role in the occurrence and development of MPN.

Methods: A total of 71 newly diagnosis MPN patients treated in Tianjin Medical University General Hospital from 2018 to 2019 were selected, including 32 patients with polycythemia vera (PV) and 22 patients with primary thrombocytosis (ET), and 17 patients with primary myelofibrosis (PMF). Then 58 patients who retestine after treatment were selected as therapy group，and 20 healthy volunteers were recruited as control group.

Augmented autophagy suppresses thymocytes development via Bcl10/p-p65 pathway in prenatal nicotine exposed fetal mice.

Tobacco smoke is a common global environmental pollutant. Maternal tobacco smoke/nicotine exposure has long-term toxic effects on immune organs. We previously found that prenatal nicotine exposure (PNE)-induced programmed immune diseases caused by fetal thymic hypoplasia, but the mechanism still unknown.

Bioconversion of bamboo shoot shell to methane assisted by microwave irradiation and fungus metabolism.

Bamboo shoot shell (BSS), a major byproduct from bamboo shoot industries with a high amount of output annually, needs to be sustainably management due to its impact on environment and human health. Anaerobic digestion is an eco-friendly and sustainable option, but its efficiency is limited by recalcitrance of lignocellulose structure. A cascade pretreatment (CP) using microwave irradiation and fungus metabolism was developed in this work to reduce the recalcitrance of BSS and enhance its methane production.