Therapeutic stapled peptides: Efficacy and molecular targets.

Peptide stapling, by employing a stable, preformed alpha-helical conformation, results in the production of peptides with improved membrane permeability and enhanced proteolytic stability, compared to the original peptides, and provides an effective solution to accelerate the rapid development of peptide drugs. Various reviews present peptide stapling chemistries, anchoring residues and one- or two-component cyclization, however, therapeutic stapled peptides have not been systematically summarized, especially focusing on various disease-related targets. This review highlights the latest advances in therapeutic peptide drug development facilitated by the application of stapling technology, including different stapling techniques, synthetic accessibility, applicability to biological targets, potential for solving biological problems, as well as the current status of development.

Autonomous ship navigation with an enhanced safety collision avoidance technique.

The motion of an autonomous ship is different from that of ground and aerial robots due to its maneuvering and environmental constraints. As a result, many techniques have been introduced for autonomous ship path planning. This paper presents a novel technique for global and local navigation planning of autonomous ships under complex static and dynamic constraints.