Publications by authors named "Qizhen Lu"
Article Synopsis
- Osteonecrosis of the femoral head (ONFH) is a severe hip disease linked to oxidative stress from high-dose glucocorticoid use, and protein disulfide isomerase (PDI) is suggested to play a crucial role in regulating oxidative stress in osteoclasts.
- The study identified 70 potential gene targets for intervention in steroid-induced ONFH, emphasizing PDI's importance through bioinformatics, network analysis, and in vitro experiments with dexamethasone (DEX), which stimulate osteoclast formation.
- Molecular docking experiments assessed various PDI inhibitors, revealing significant binding energies and interaction mechanisms, suggesting that PDI plays a positive regulatory role in osteoclastogenesis stimulated by dexamethasone
Aim Of The Study: Osteolysis in Rheumatoid arthritis (RA) is principally provoked by osteoclast hyperactivity. This study aims to employ Corydaline (Cory), a plant extract, as an osteoclast inhibitor in treating RA-inflicted osteolysis while unveiling the corresponding mechanism.
Materials And Methods: Osteoclasts were derived from mouse bone marrow-derived monocytes (BMMs) stimulated with M-CSF and RANKL.
Purpose: To investigate the current status and related influencing factors of self-management stages in older patients with chronic pain.
Design: A cross-sectional study.
Methods: A total of 326 older patients with chronic pain were selected as the study subjects in five city districts from December 2022 to June 2023.
The onset of osteonecrosis of the femoral head (ONFH) is intimately associated with the extensive administration of glucocorticoids (GCs). Long-term stimulation of GCs can induce oxidative stress in both osteoclasts (OCs) and osteoblasts (OBs), resulting in the disturbance of bone remodelling. An alkaloid named crebanine (CN) demonstrates pharmacological properties including anti-inflammation and reactive oxygen species (ROS) modulation.
View Article and Find Full Text PDFBackground: Increased osteoclast activity constitutes the primary etiology of excessive bone erosion in postmenopausal osteoporosis. ERp57, otherwise referred to as protein disulfide isomerase A3 (PDIA3), plays a crucial role in the regulation of intracellular calcium signaling. This is documented to exert a profound impact on osteoclast differentiation and functionality.
View Article and Find Full Text PDFAim: To evaluate the effect of olfactory and/or gustatory stimulation interventions on feeding outcomes in preterm infants.
Methods: We conducted systematic searches across various academic databases, including PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Service System, China National Knowledge Infrastructure, the Wanfang Database, and the Wipu Database. These searches aimed to identify randomized controlled trials investigating the impact of olfactory and/or gustatory stimulation on preterm infants.
Background: Older people in the nursing home environment are much less mobile and capable of taking care of themselves as they age, and most of them face the plight of loneliness, which seriously affects the quality of life of older people in their later years.
Aims: A systematic review and synthesis of older people's experiences of loneliness in nursing homes.
Design: Following ENTREQ, do a systematic evaluation and synthesis of qualitative investigations.