Kueishanamides A and B from the Hydrothermal Vent Sediment Derived Streptomyces sp. WU20.

Marine actinomycetes are known for their production of remarkable organic molecules, particularly those featuring polyoxygenated long-chain backbones. Determining the absolute configurations of these compounds remains a challenging task even today. In this study, we successfully established the planar structures and absolute configurations of two highly flexible amide alkaloids from Streptomyces sp.

Characterization of New Gambierones Produced by 1123M1M10.

The benthic dinoflagellate genus is the primary producer of toxins responsible for ciguatera poisoning (CP), a food intoxication endemic in tropical and subtropical areas of the world. We used high-performance liquid chromatography tandem high-resolution mass spectrometry (HPLC-HRMS) to investigate the toxin profile of 1123M1M10, which was obtained from Marakei Island (2°01'N, 173°15'E), Republic of Kiribati, located in the central Pacific Ocean. Four new gambierone analogues including 12,13-dihydro-44-methylgambierone, 38-dehydroxy-12,13-dihydro-44-methylgambierone, 38-dehydroxy-44-methylgambierone, and desulfo-hydroxyl gambierone, and two known compounds, gambierone and 44-methylgambierone, were proposed by analyzing their fragmentation behaviors and pathways.

Chemistry and bioactivities of alkaloids isolated from marine fungi (covering 2016-2022).

The ocean is a treasure house with rich resources of new chemical and biological molecules. A growing body of evidence suggests that marine fungi represent a huge and largely untapped resource of natural products that have been optimized by evolution for biological and ecological relevance. Alkaloids, the important components of natural products, have attracted much attention from medicinal and natural product chemists due to their unique structures and biological potential.

Structures and bioactivities of secondary metabolites from Penicillium genus since 2010.

Penicillium genus was a fungal endophyte first reported by Alexander Fleming in 1928 and attracted more attention in recent decades due to its multitudinous metabolites which possess novel skeletons, abundant bioactivities and potential in medicine. Up to now, >300 Penicillium species were found all around the world. The review summarized secondary metabolites derived from the Penicillium genus since 2010, including their chemical structures and biological activities.

Cytotoxic shornephines and asterresins from the hydrothermal vent associated fungus Aspergillus terreus CXX-158-20.

A previously unreported alkaloid, bearing an undescribed 5/7/8 tricyclic heterocyclic skeleton, shornephine D, an undescribed diketomorpholine (DKM) shornephine B, two undescribed diketomorpholine derivatives shornephine C and seco-shornephine B methyl ester, an undescribed indole-isoquinoline alkaloid asterresin C, three undescribed indole alkaloids asterresins A-B and D, together with five known compounds, were isolated from the culture of hydrothermal vent associated fungus Aspergillus terreus CXX-158-20. Their structures were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry, Mosher's method, C NMR calculation in combination with DP4+, and ECD calculations. Shornephine D and asterresin C represent two undescribed heterocyclic skeletons.

Citrinin Monomer, Trimer, and Tetracyclic Alkaloid Derivatives from the Hydrothermal Vent-Associated Fungus TW132-59.

Five new unusual citrinin-derived alkaloids with a tetracyclic core, citrinidines A-E (-), two new amide alkaloids, methyl (2,8)-1'-(2-methyl-3-oxodec-8-enamido) butanoate () and (2,8)-2-methyl-3-oxodec-8-enamide (), a new unusual citrinin trimer, tricitrinol C (), a new citrinin acetal-ketal derivative, citrininol (), together with four known citrinin monomers (-), and three known citrinin dimers (), were isolated from the fermentation of hydrothermal vent-associated fungus TW132-59. Their structures were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry, Mosher's method, C NMR calculation in combination with DP4+, and ECD calculations. A plausible biosynthetic pathway of all new compounds (-) was proposed.

New Cytotoxic Secondary Metabolites from Two Deep-Sea-Derived Fungi and the Co-Culture Impact on the Secondary Metabolic Patterns.

In this study, chemical profiles for two co-existing deep-sea-derived Penicillium fungal strains were thoroughly investigated. Two new compounds and 11 known compounds were identified from Penicillium sp. LXY140-R, while one new compound and 12 known compounds were isolated from Penicillium sp.