Publications by authors named "Qizhao Tan"

Background: Osteoarthritis (OA) of the knee joint is a prevalent joint disease that affects most aging individuals worldwide. An extract of garlic oil, diallyl disulfide (DADS), reportedly protects chondrocytes in vitro, with limited data available on its in vivo OA effects. We explored the efficacy of DADS in ovariectomy (OVX)-induced OA rats.

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Article Synopsis
  • The study evaluates the effectiveness of 3D-printed porous Ti6Al4V prostheses for treating partial bone defects in lower limbs caused by osteomyelitis, aiming to improve clinical management of such challenging cases.
  • A comprehensive protocol was developed, including 3D simulations and finite element analysis (FEA) to assess stress conduction before and after prosthesis implantation, with a clinical study involving eight patients to monitor outcomes.
  • Results showed that the prostheses successfully reduced stress on residual bone, leading to significant functional improvements in most patients, with long-term stability and some instances of infection that required further intervention.
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Osteoarthritis (OA) is a prevalent debilitating whole-joint disorder. Currently, a growing number of proteomic studies have been performed to evaluate molecular biomarkers in several tissues from OA patients; however, little is known about the protein profiles in subchondral bone of OA. In this study, proteomic analysis was performed on subchondral bone from patients with OA to identify differentially expressed proteins (DEPs).

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Osteoarthritis (OA) is a whole-joint disease and characterized by alterations in the articular cartilage, subchondral bone, ligaments, and synovial membrane. The crosstalk between cartilage and subchondral bone plays a crucial role in the pathogenesis and progression of OA. Hypoxia has been reported to play an important role in cartilage degradation and subchondral bone remodeling in OA.

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Introduction: Different opinions exist about the role of subchondral bone in osteoarthritis (OA), probably because subchondral bone has different effects on cartilage degeneration in OA induced by different pathologies. Animal studies to illustrate the role of subchondral bone in cartilage degeneration were mostly based on post-traumatic OA (PT-OA). Postmenopausal women experience a much higher occurrence of OA than similar-aged men.

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Background: Emerging knowledge has highlighted the role of periostin (POSTN) in osteoarthritis (OA) process; however, whether POSTN is suitable as a biomarker of OA remains unclear. This study aimed to investigate the potential value of POSTN as a biomarker of OA.

Methods: Ten 6-month-old female Sprague-Dawley (SD) rats were used in this study.

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Purpose: Nowadays, there is no clinically applicable biomarker for osteoarthritis (OA). Therefore, the aim of the study is to discover a potential biomarker for OA.

Experimental Design: We performed a proteomics of eight cartilage samples (four damaged cartilage and four macroscopically intact cartilage) from four OA patients without any comorbidities to search for valuable OA biomarkers.

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Article Synopsis
  • This study investigates the role of MMP-13, a protein involved in cartilage remodeling, as a potential biomarker for osteoarthritis (OA) by comparing its levels in patients with advanced OA to those without the condition.* -
  • A total of 51 patients were analyzed, and results showed significantly higher levels of serum MMP-13 in those with advanced OA, along with correlations to clinical symptoms and severity as assessed by established scoring systems.* -
  • The findings suggest that MMP-13 could be a valuable tool for diagnosing and predicting the severity of OA, but more research is needed to fully understand its mechanisms and clinical applications.*
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Osteoarthritis (OA) is a joint disorder involving cartilage degeneration and subchondral bone sclerosis. The bone-cartilage interface is implicated in OA pathogenesis due to its susceptibility to mechanical and biological factors. The crosstalk between cartilage and the underlying subchondral bone is elevated in OA due to multiple factors, such as increased vascularization, porosity, microcracks and fissures.

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Background: Osteoarthritis (OA) is prevalent in postmenopausal women. Subchondral bone in ovariectomized (OVX) rats might play a more important role in cartilage degeneration compared with other types of OA. How subchondral osteoblast changes in OVX rats is still unclear.

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Background: Osteoarthritis (OA) is a joint disease that leads to a high disability rate and a low quality of life. With the development of modern molecular biology techniques, some key genes and diagnostic markers have been reported. However, the etiology and pathogenesis of OA are still unknown.

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