A novel oxidized hierarchical porous carbon with vesicule-like ultrathin graphitic walls for efficient removal of anionic and cationic dyes.

This work developed a novel oxidized hierarchical porous carbon (OHPC) with vesicule-like ultrathin graphitic walls via a method of air oxidation and used as an efficient adsorbent for Congo red (CR) and Malachite green (MG) removal. Results show that the OHPC2 oxidized at 400 °C possesses three-dimensional hierarchical pores with vesicule-like ultrathin graphitic walls. The prepared OHPC2 not only has a large specific surface area of 1020 m g with a high pore volume, but also has abundant oxygen-containing functional groups.

Luteolin Alleviates the TNF--Induced Inflammatory Response of Human Microvascular Endothelial Cells via the Akt/MAPK/NF-B Pathway.

Endothelial dysfunction and pathological alterations are pivotal in the pathogenesis of cardiovascular disease. To date, effective interventions for these endothelial changes are lacking. Tumor necrosis factor-alpha (TNF-) is known to significantly contribute to these alterations.

Mixture toxicity of the heavy metal copper and the fluoroquinolone antibiotic ciprofloxacin on Microcystis aeruginosa.

Exposure to chemical mixtures is the norm in natural environments. Yet, water quality regulations are still mostly constructed for individual chemicals. However, an important ambition of the European Green Deal is the future implementation of mixture toxicity to address the risks posed by the joint presence of multiple chemicals in aquatic ecosystems (e.

Mapping the risk of ciprofloxacin in European water bodies: Incorporating the impact of bioavailability.

Widespread use of ciprofloxacin (CIP) in surface waters has raised ecological and human health concerns. However, the measured environmental concentration (MEC) of CIP may not directly indicate its ecological impact because CIP bioavailability and thus toxicity are influenced by environmental factors, such as pH and dissolved organic carbon (DOC). The present study integrates CIP toxicity as a function of pH and DOC into an environmental risk assessment (ERA) of CIP in European surface waters.

A novel snake venom C-type lectin-like protein modulates blood coagulation by targeting von Willebrand factor and coagulation factor IX.

Snake venom C-type lectin-like proteins (CLPs) belong to the nonenzymatic proteins. To date, no CLP with both platelet and coagulation factors activating activities has been reported. In this study, a novel CLP, termed protocetin, with molecular weight of 29.

Effect of Mono- and Polysaccharide on the Structure and Property of Soy Protein Isolate during Maillard Reaction.

As a protein extracted from soybeans, soy protein isolate (SPI) may undergo the Maillard reaction (MR) with co-existing saccharides during the processing of soy-containing foods, potentially altering its structural and functional properties. This work aimed to investigate the effect of mono- and polysaccharides on the structure and functional properties of SPI during MR. The study found that compared to oat β-glucan, the reaction rate between SPI and D-galactose was faster, leading to a higher degree of glycosylation in the SPI-galactose conjugate.

Baicalin relieves complement alternative pathway activation-induced lung inflammation through inhibition of NF-κB pathway.

Introduction: Acute lung injury (ALI) as one kind of acute pulmonary inflammatory disorder, manifests primarily as damage to alveolar epithelial cells and microvascular endothelial cells. Activation of the complement system is a common pathological mechanism in ALI induced by diverse factors, with the complement alternative pathway assuming a pivotal role. Baicalin, a flavonoid derived from the root of Scutellaria baicalensis Georgi, exhibits noteworthy biological activities.

Corrigendum to "Atrase A, a P-III class metalloproteinase purified from cobra venom, exhibits potent anticoagulant activity by inhibiting coagulation pathway and activating the fibrinolytic system" [Heliyon Volume 10, Issue 10, 30 May 2024, Article e30969].

[This corrects the article DOI: 10.1016/j.heliyon.

Atrase A, a P-III class metalloproteinase purified from cobra venom, exhibits potent anticoagulant activity by inhibiting coagulation pathway and activating the fibrinolytic system.

Snake venoms, comprising a complex array of protein-rich components, an important part of which are snake venom metalloproteinases (SVMPs). These SVMPs, which are predominantly isolated from viperid venoms, are integral to the pathology of snakebites. However, SVMPs derived from elapid venoms have not been extensively explored, and only a handful of SVMPs have been characterized to date.

Training semantic long-term memory retrieval transfers to executive function and reading fluency.

The retrieval of information from long-term memory is a fundamental cognitive ability, crucial for most aspects of successful human functioning. Whether and how long-term memory retrieval (LTMR) can be improved with training has clear societal importance but also theoretical value for furthering our understanding of underlying mechanisms. Here, we provide electrophysiological evidence for the plasticity of semantic LTMR.

Icariin ameliorates LPS-induced acute lung injury in mice via complement C5a-C5aR1 and TLR4 signaling pathways.

Acute lung injury (ALI) is an acute respiratory-related progressive disorder, which lacks specific pharmacotherapy. Icariin (ICA) has been shown to be effective in treating ALI. However, the targets and pharmacological mechanisms underlying the effects of ICA in the treatment of ALI are relatively lacking.

The influence of pH and dissolved organic carbon on the ecotoxicity of ampicillin and clarithromycin.

The impacts of water chemistry properties including pH and dissolved organic carbon (DOC) on the ecotoxicity of active pharmaceutical ingredients (APIs) are increasingly evident. These impacts are a result of alterations in API bioavailability: pH regulates the bioavailability of many ionizable APIs via chemical speciation, whereas DOC interacts with several APIs to inhibit the APIs from traversing the membrane system of organisms. In this study, we examined the influences of pH and DOC on the bioavailability of ampicillin (AMP) and clarithromycin (CLA) with the help of a bioavailability model.

Effect of Oat β-Glucan on the Structure and Properties of Soybean Protein Isolate During Maillard Reaction.

Maillard reaction (MR) with oat β-glucan changed the structure of soybean protein isolate (SPI), further leading to the enhancement of its functional properties. SPI was unfolded by MR, and the SPI conjugates with high molecular weight were identified. The water solubility of SPI was improved by cross-linking with hydrophilic β-glucan, while the hydrophobicity also increased along with the unfolding of the SPI.

Water brownness regulates the bioavailability of a fluoroquinolone antibiotic: UV-absorbance as a predictor of ciprofloxacin ecotoxicity.

Dissolved organic carbon (DOC) is a powerful regulator of the ecotoxicity of ciprofloxacin (CIP), a widely applied fluoroquinolone antibiotic. In this study, we investigated the impact of DOC from a variety of sources on CIP bioavailability, using a cyanobacteria growth inhibition test with Microcystis aeruginosa. We analyzed the impact from two perspectives: (1) DOC concentration, and (2) water brownness, defined in this work as the light absorbance of DOC solutions.

Physicochemical and functional property of the Maillard reaction products of soy protein isolate with L-arabinose/D-galactose.

Background: Soy protein isolate (SPI) is widely used in the food industry because of its nutritional and functional properties. During food processing and storage, the interaction with co-existing sugars can cause changes in the structural and functional properties of SPI. In this study, SPI-l-arabinose conjugate (SPI:Ara) and SPI-d-galactose conjugate (SPI:Gal) were prepared using Maillard reaction (MR), and the effects of five-carbon/six-carbon sugars on the structural information and function of SPI were compared.

Salvianolic acid A alleviates lipopolysaccharide-induced disseminated intravascular coagulation by inhibiting complement activation.

Introduction: Disseminated intravascular coagulation (DIC) is a syndrome characterized by coagulopathy, microthrombus, and multiple organ failure. The complement system in DIC is overactivated, and the functions of complement and coagulation pathways are closely related. Our previous screening revealed that salvianolic acid A (SAA) has anti-complement activity.

A Bioavailability Model to Predict the Impact of pH and Dissolved Organic Carbon on Ciprofloxacin Ecotoxicity to the Cyanobacterium Microcystis aeruginosa.

Ciprofloxacin (CIP) is a pseudopersistent antibiotic detected in freshwater worldwide. As an ionizable chemical, its fate in freshwater is influenced by water chemistry factors such as pH, hardness, and dissolved organic carbon (DOC) content. We investigated the effect of pH, DOC, and Ca levels on the toxicity of CIP to Microcystis aeruginosa and developed a bioavailability model on the basis of these experimental results.

Traditional Chinese Medicine Constitution Discrimination Model Based on Metabolomics and Random Forest Decision Tree Algorithm.

Constitution refers to the comprehensive and relatively stable characteristics of the genetic or acquired morphological structure, physiological function, and psychological state in the process of human individual life. A special metabolomics data processing method is established to find the unique value of each constitution. Combined with the random forest decision tree algorithm, the discrimination model of 9 constitutions in traditional Chinese medicine is constructed, and the model is verified and tested.

Elucidation of the Transport Mechanism of Puerarin and Gastrodin and Their Interaction on the Absorption in a Caco-2 Cell Monolayer Model.

Puerarin (PUR) and gastrodin (GAS) are often used in combined way for treating diseases caused by microcirculation disorders. The current study aimed to investigate the absorption and transportation mechanism of PUR and GAS and their interaction via Caco-2 monolayer cell model. In this work, the concentration in Caco-2 cell of PUR and GAS was determined by HPLC method.

Simultaneous Determination of Ten Bioactive Components from Shenling Baizhu San in Rat Plasma by UHPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Two Models of Ulcerative Colitis Rats.

Shenling Baizhu San, a traditional formula, has a long history of treating spleen asthenic diarrhea by invigorating the spleen and dispelling dampness in China. A rapid and accurate UHPLC-MS/MS method was developed and fully validated for the simultaneous determination of ten active constituents in rat plasma: panaxadiol, ginsenoside Rg1, atractylenolide I, atractylenolide III, pachymic acid, neferine, nuciferine, diosgenin, platycodin D, and isoliquiritigenin. The plasma samples were pretreated by the protein precipitation method with acetonitrile.

Metabonomic Study on the Plasma of High-Fat Diet-Induced Dyslipidemia Rats Treated with Ge Gen Qin Lian Decoction by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry.

Gegen Qinlian decoction (GGQLD) has a definite effect on T2DM in clinic, and it has the effect of lowering blood sugar, improving insulin resistance, and improving the blood lipid level of rats with dyslipidemia, but the intervention mechanism of GGQLD on dyslipidemia has not been clarified. The changes in endogenous metabolites in the plasma of high-fat diet-induced dyslipidemia rats treated with Ge Gen Qin Lian Decoction (GGQLD) were studied to elucidate the therapeutic effects and mechanism of action of GGQLD in dyslipidemia. Based on ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS), the metabolic profiles of rat serum samples were collected.

Deciphering the Formulation Secret Underlying Chinese Huo-Clearing Herbal Drink.

Herbal teas or herbal drinks are traditional beverages that are prevalent in many cultures around the world. In Traditional Chinese Medicine, an herbal drink infused with different types of medicinal plants is believed to reduce the 'Shang Huo', or excessive body heat, a status of sub-optimal health. Although it is widely accepted and has a very large market, the underlying science for herbal drinks remains elusive.

Facile preparation of robust dual MgO-loaded carbon foam as an efficient adsorbent for malachite green removal.

This study developed a facile approach for the fabrication of dual MgO-loaded carbon foam (DMCF) via carbonization of a cured MgO/cyanate ester resin mixture, which underwent self-foaming of the resin followed by the carbothermal reduction of MgO. The features of the prepared DMCF prepared were characterized by FESEM, TEM, XRD, FTIR, XPS and so on, and the effects of adsorption conditions, adsorption isotherms, kinetics, and thermodynamics on malachite green (MG) removal using the DMCF as adsorbents were investigated through batch adsorption experiments. Results demonstrate that the DMCF possesses a unique dual loading of MgO particles which are not only loaded onto its foam walls but also filled within the walls with a graphene-wrapped core-shell structure.

A stiff ZnO/carbon foam composite with second-level macroporous structure filled ZnO particles for heavy metal ions removal.

A stiff zinc oxide/carbon foam (ZnO/CF) composite as a desirable adsorbent for heavy metal ions was innovatively designed and fabricated by loading ZnO particles into a carbon foam with capsule-like second-level macropores. The features of the resulting composite were characterized by FESEM, XRD, BET, FTIR, and XPS. The effects of adsorption parameters on the Pb(II), Cr(III), and Cu(II) ions removal were studied through batch experiments.

A novel hierarchical stiff carbon foam with graphene-like nanosheet surface as the desired adsorbent for malachite green removal from wastewater.

A novel hierarchical stiff carbon foam (HSCF) was successfully prepared via a carbothermal reduction between the carbon foam with two-level pore structure and the AlO from aluminum sulfate, and used as a bulk adsorbent for removing malachite green (MG) dye. The structures of the HSCF were characterized using SEM, XRD, FTIR, BET, and XPS, and the effects of adsorption condition on the MG removal were studied through batch adsorption experiments. Results show that large-sized and complex-shaped HSCF can be easily fabricated with a high compression strength of 1.