A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels.

Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (HS) has been found to have anti-seizure effects. However, its mechanism remains to be explored.

A Novel Hydrogen Sulfide Donor Reduces Pilocarpine-Induced Status Epilepticus and Regulates Microglial Inflammatory Profile.

Although epilepsy is one of the most common neurologic disorders, there is still a lack of effective therapeutic drugs for it. Recently, we synthesized a novel hydrogen sulfide (HS) donor, which is found to reduce seizures in animal models effectively. But it remains to be determined for its mechanism.

A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling.

Epilepsy is a serious neurological disorder. Available antiepileptic drugs are still lacking. Hydrogen sulfide (HS), a neuron-protective endogenous gasotransmitter, is reported to have effect on epilepsy.