IARS2 mutations lead to Leigh syndrome with a combined oxidative phosphorylation deficiency.

Background: Leigh syndrome (LS) is a common mitochondrial disease caused by mutations in both mitochondrial and nuclear genes. Isoleucyl-tRNA synthetase 2 (IARS2) encodes mitochondrial isoleucine-tRNA synthetase, and variants in IARS2 have been reported to cause LS. However, the pathogenic mechanism of IARS2 variants is still unclear.

A novel pathogenic mitochondrial DNA variant m.4344T>C in tRNA causes developmental delay.

Mitochondrial diseases are a group of genetic diseases caused by mutations in mitochondrial DNA and nuclear DNA. However, the genetic spectrum of this disease is not yet complete. In this study, we identified a novel variant m.

Virtual sample generation empowers machine learning-based effluent prediction in constructed wetlands.

The design of constructed wetlands (CWs) is critical to ensure effective wastewater treatment. However, limited availability of reliable data can hamper the accuracy of CW effluent predictions, thus increasing design costs and time. In this study, a novel effluent prediction framework for CWs is proposed, utilizing data dimensionality reduction and virtual sample generation.

Achieving Practical Venue Recycle of Waste Oil-Based Drilling Fluids with Vacuum Distillation Technology.

Drilling fluids are essential operating additives for extracting oil and shale gas. Thus, their pollution control and recycling utilization are significant to petrochemical development. Vacuum distillation technology was used in this research to handle waste oil-based drilling fluids and achieve reutilization.

Towards the carbon neutrality of sludge treatment and disposal in China: A nationwide analysis based on life cycle assessment and scenario discovery.

Motivated by the carbon neutrality target, strategic planning for a low-carbon transition of sludge treatment and disposal in China is challenging due to the unpredictability of technical, regional, socioeconomic, and political factors affecting greenhouse gas (GHG) emissions. This study combines the use of a Life Cycle Assessment and the Patient Rule Induction Method, accounting for possibilities that could achieve net-zero carbon emissions by exploring multiple plausible future profiles of sludge treatment and disposal. Results show that reducing sludge landfill and increasing anaerobic digestion are effective methods to facilitate GHG reduction.

Silicon-mediated regulation of cadmium transport and activation of antioxidant defense system enhances Pennisetum glaucum resistance to cadmium stress.

Pennisetum glaucum is an important forage grass for livestock. However, the large accumulation of cadmium (Cd) in plant tissues increases the risk of heavy metals entering the food chain in Cd-contaminated soils. Silicon (Si) can inhibit cadmium (Cd) uptake and enhance tolerance of plant to Cd toxicity, but whether and how Si alleviates Cd toxicity in grass and the underlying mechanisms are unclear.

Subjective strain of care experienced by pulmonary and critical care medical nurses when caring for patients with delirium: a cross-sectional study.

Background: Delirium, a disorder of consciousness, often occurs for a period of time during hospitalisation. It is characterised by a disturbance of attention or awareness. Hyperactive delirium may lead to accidental removal of medical equipment, while hypoactive delirium may inhibit patients from participating in nursing interventions, medical treatment, and physical therapy.

Silicon Amendment Reduces Soil Cd Availability and Cd Uptake of Two Species.

Silicon (Si) plays important roles in alleviating heavy metal stress, but the migrating effects and mechanisms, especially for , are not well studied. In this study, and × were used to explore the impacts of Si application on alleviating cadmium (Cd) toxicity and its possible mechanism. Treatments consist of four levels of Cd (0, 10, 50, and 100 mg·kg) with or without 2.