Publications by authors named "Qiying Bao"
Background: Up to 80 % of chemotherapeutic drugs induce myelosuppression in patients. Chemotherapy not only impairs of hematopoietic stem cells (HSCs) but also damages bone marrow niches (vascular and endosteal). Current treatments for myelosuppression overlook these chemotherapy-induced damages to bone marrow niches and the critical role of niche restoration on hematopoietic regeneration.
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- Idebenone is an antioxidant that appears to protect HT22 cells from oxidative stress by targeting CD38 to up-regulate SIRT3, which then deacetylates P53 and reduces apoptosis.
- The study utilized flow cytometry and TUNEL staining to confirm that Idebenone decreases levels of apoptosis and related proteins, specifically P53 and Caspase3, in HO-injured HT22 cells.
- Findings suggest that Idebenone could have therapeutic potential for neurodegenerative diseases like Parkinson's and Alzheimer's by mitigating oxidative damage associated with CD38-related disorders.