Chlojaponilactone B Attenuates THP-1 Macrophage Pyroptosis by Inhibiting the TLR/MyD88/NF-κB Pathway.

Pyroptosis, an innate immune response, plays a crucial role in the pathological process of inflammatory diseases. Although pyroptosis blockade is considered a potential therapeutic strategy, no ideal candidate drug has been identified. The natural product Chojaponilactone B (CJB) has demonstrated anti-inflammatory effects, but its role in macrophage pyroptosis has not been studied.

Neuroprotective Effects of a New Derivative of Chlojaponilactone B against Oxidative Damaged Induced by Hydrogen Peroxide in PC12 Cells.

A new sesquiterpenoid () was obtained by hydrogenating Chlojaponilactone B. The structure of was elucidated according to a combination of NMR, HRESIMS, and NOE diffraction data. The treatment of HO in a PC12 cell model was used to evaluate the antioxidant activity of .

(±)-Sarcanan A, a pair of new enantiomeric dihydrobenzofuran neolignans from the aerial parts of .

(+)-Sarcanan A () and (-)-Sarcanan A (), a pair of new dihydrobenzofuran neolignan enantiomers, together with six known compounds (-), were isolated from the aerial parts of . Their structures were elucidated by spectroscopic analysis, and the absolute configurations of and were determined by analyses of the electronic circular dichroism (ECD) data. All compounds were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.