FTACMT study protocol: a multicentre, double-blind, randomised, placebo-controlled trial of faecal microbiota transplantation for autism spectrum disorder.

Introduction: Autism spectrum disorder (ASD) is a complicated diffuse developmental disorder that commonly involves gastrointestinal distress and dysbacteriosis. Emerging lines of evidence have shown faecal microbiota transplantation (FMT) to be a potential therapeutic strategy for improving the clinical outcomes of patients with ASD by re-establishing their intestinal microflora. We are undertaking the first-ever multicentre, double-blind, randomised controlled trial of FMT for the treatment of children with both ASD and gastrointestinal symptoms and will assess the feasibility and efficacy outcomes of this strategy.

In-line hemofiltration minimized extracorporeal membrane oxygenation-related inflammation in a porcine model.

We evaluated a pattern for connecting a hemofiltration apparatus after the ECMO oxygenator and observed the effects on the levels of inflammatory cytokines. All animals were anesthetized and ventilated, were randomly divided into 3 groups and observed for 24 h: S group (n = 6) received cannulation and heparin infusion; E group (n = 6) received venovenous (VV)-ECMO and heparin infusion; E+H group (n = 6) received hemofiltration with VV-ECMO placed after the oxygenator and heparin infusion. Hemodynamics, gas exchange parameters and plasma cytokine levels were measured simultaneously.

Effects of continuous renal replacement therapy on renal inflammatory cytokines during extracorporeal membrane oxygenation in a porcine model.

Background: Extracorporeal membrane oxygenation (ECMO) has been recommended for the treatment of patients with acute, potentially reversible, life-threatening respiratory failure which unresponsive to conventional therapy. But it is unclear about how ECMO affects renal tissue.

Methods: Twenty-four piglets weighing 25 to 32 kg were used in this experiment.