Publications by authors named "Qiyao Luo"
During the early growth stages of fish larvae, there are significant challenges to their viability, so improving their visual environment is essential to promoting their growth and survival. Following the successful knockout of thyroid hormone receptor beta 2 () using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology, there was an increase in the expression of UV opsin (short-wave-sensitive 1, ), while the expression of other cone opsins was significantly decreased. Further analysis of the retinal structure demonstrated that the knockout resulted in an increased lens thickness and a decreased thickness of the ganglion cell layer (GCL), outer plexiform layer (OPL), and outer nuclear layer (ONL) in the retina.
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- Target fishing uses reverse docking to find potential proteins that bind to specific ligands, but current scoring methods often misidentify true targets due to bias based on protein pocket properties.
- A large-scale study involving 5,000 molecules and 100 proteins revealed that interference proteins consistently caused false positives across three docking programs (DOCK, Glide, AutoDock Vina) due to their larger contact areas and higher hydrophobicity.
- Implementing a score normalization method effectively reduced scoring bias, leading to a 21.5% improvement in target prediction accuracy for Glide, while showing inconsistent results for DOCK and AutoDock Vina.