Publications by authors named "Qiyang Ding"
Article Synopsis
- - This study explored how mitochondrial dynamics influence postoperative cognitive dysfunction (POCD) and tested the drug Mdivi-1, which inhibits a protein called DRP1, as a potential treatment.
- - Results showed that inhibiting DRP1 with Mdivi-1 reduced neuroinflammation and improved cognitive function by decreasing mitochondrial fission and reactive oxygen species (ROS) production, while also stabilizing the mitochondrial membrane.
- - Additionally, Mdivi-1 increased synaptic plasticity and spine density in the hippocampus, leading to better cognitive performance in tests, highlighting mitochondrial health as a key factor in POCD and the promise of DRP1 inhibition for treatment.
Int J Nanomedicine
July 2023
Article Synopsis
- Anesthetics are essential drugs used in surgery that help manage pain and promote relaxation, but they often have toxic side effects and face challenges in crossing the blood-brain barrier (BBB).
- Loading anesthetics onto nanocarriers could enhance their effectiveness while minimizing adverse effects, making anesthetic nanomedicines a promising area of research.
- While local anesthetic nanomedicines have gained attention and are meeting clinical needs, research on nanomedicines for general anesthetics is limited, highlighting an urgent need for comprehensive studies in this field.
