Publications by authors named "Qixin Yu"
Article Synopsis
- The NLRP3 inflammasome complex is important in various inflammation-related diseases, and researchers developed new sulfonamide analogues to inhibit it.
- One compound showed strong inhibition at a low concentration (IC: 0.13 μM) and low toxicity, effectively blocking NLRP3 activation and cell pyroptosis.
- In tests using a colitis model, this compound significantly reduced inflammation and showed promise for the treatment of inflammatory bowel disease with a favorable safety profile.
As "Michael acceptors" may induce promiscuous responses in mammalian cells by reacting with various proteins, we modified the cinnamamide of our previous hydrazide-based HDAC inhibitors (HDACIs) to deactivate the Michael reaction. Representative compound is 2-5 times more potent than lead compound in both HDAC inhibitory activity (IC = 0.43-3.
View Article and Find Full Text PDFThe article Dietary protein intake and subsequent risk of type 2 diabetes: a dose-response meta-analysis of prospective cohort studies written by Jianhong Ye, Qixin Yu, Weihua Mai, Peiling Liang, Xiaoxia Liu, Yunnan Wang was originally published electronically on the publisher's internet portal (currently SpringerLink) on 30 March 2019 with open access. With the author(s)' decision to step back from Open Choice, the copyright of the article changed on 30 May 2019 to © Springer-Verlag Italia S.r.
View Article and Find Full Text PDFAims: Dietary proteins, including those obtained from animal and plant sources, have inconsistently been correlated with type 2 diabetes mellitus (T2DM) risk. Therefore, a meta-analysis was conducted to evaluate the association between dietary proteins and the risk of T2DM.
Methods: Prospective cohort studies published until November 2018 were systematically searched in PubMed, Embase, and the Cochrane library.