Metallic nano-warriors: Innovations in nanoparticle-based ocular antimicrobials.

Eye infection is one of the most important causes of blindness. Due to the particularity of ocular structure, the enhancement of bacteria resistance, and the significant side effects of long-term medication, it is difficult to treat ocular antimicrobial diseases. The efficacy of medications currently employed is progressively becoming more restricted.

Down-expression of the NLRP3 inflammasome delays the progression of diabetic retinopathy.

The investigation aimed to evaluate the effects of Mcc950, an inhibitor of the NLRP3 inflammasome, on diabetic retinopathy (DR) mice. The general physiological condition of each group of mice was recorded. Retinal blood vessels were stained for observation of the density of blood vessels, and retinas were used for further morphological examination and fluorescent staining after the intravitreal injection of Mcc950.

LINC01315 Impairs microRNA-211-Dependent DLG3 Downregulation to Inhibit the Development of Oral Squamous Cell Carcinoma.

Recent studies have revealed that long non-coding RNAs (lncRNAs) involve in the progression of oral squamous cell carcinoma (OSCC). These lncRNAs have emerged as biomarkers or therapeutic targets for OSCC. We here aimed to investigate the role of lncRNA LINC01315 in OSCC and the related mechanisms.

Knockout of NRAGE promotes autophagy-related gene expression and the periodontitis process in mice.

Background And Objective: Neurotrophin receptor-interacting MAGE homologue (NRAGE) plays a crucial role in the regulation of bone metabolism. The present study investigated the regulation role of NRAGE on autophagy activation and periodontitis process during experimental periodontitis.

Materials And Methods: Six-week-old wild-type (WT) and NRAGE-/- mice were randomly divided into three time points in the periodontitis groups (0, 2, and 4 weeks).

Bearing capacity of ceramic crowns before and after cyclic loading: An in vitro study.

The objective of this study was to compare the resistance to failure of three types of all-ceramic crowns under static and cyclic contact loading. Three types of crown specimens were fabricated (N = 14 per group) including: i) sintered bi-layer crowns (SBC) made of IPS e.max CAD veneers fused on Lava zirconia core ceramics, ii) adhesive bi-layer crowns (ABC) made of IPS e.

Animal Models Used for Testing Hydrogels in Cartilage Regeneration.

Local cartilage or osteochondral lesions are painful and harmful. Besides pain and limited function of joints, cartilage defect is considered as one of the leading extrinsic risk factors for osteoarthritis (OA). Thus, clinicians and scientists have paid great attention to regenerative therapeutic methods for the early treatment of cartilaginous defects.

The Formation Mechanism of Hydrogels.

Hydrogels are degradable polymeric networks, in which cross-links play a vital role in structure formation and degradation. Cross-linking is a stabilization process in polymer chemistry that leads to the multi-dimensional extension of polymeric chains, resulting in network structures. By crosslinking, hydrogels are formed into stable structures that differ from their raw materials.

[Research on the mechanical differences of machinable lithium disilicate all-ceramic crowns].

Due to the superior pigment and high flexural strength, machinable lithium disilicate ceramics can be used as a monolithic crown or veneering porcelains on the zirconia core to form the all-ceramic crowns by sintering or bonding procedures. This paper reports the research on the differences in stress distributions amongst these three types of all-ceramic crowns under typical loading conditions. Three-dimensional numerical models of the restored crown based on the first mandibular molar were developed.

The properties of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and its applications in tissue engineering.

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a member of the polyhydroxyalkanoate (PHA) family. It is the designation of molecules consisting of random co-polymers of 3-hydroxybutyrate and 3- hydroxyhexanoate. PHBHHx plays a significant role in the field of biomedical materials.