Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission.

Both human and animal experiments have demonstrated that energy metabolism dysfunction in neurons after seizures is associated with an imbalance in mitochondrial fusion/fission dynamics. Effective neuronal mitochondrial dynamics regulation strategies remain elusive. Nicotinamide mononucleotide (NMN) can ameliorate mitochondrial functional and oxidative stress in age-related diseases.

The range and habitat suitability of François' langur (Trachypithecus francoisi) in Mayanghe Nature Reserve, China.

The François' langur (Trachypithecus francoisi) is an endangered primate living in limestone forests in Vietnam and China. From October 2017 to August 2018, the habitat preferences and the range of the Francois' langur were surveyed in the Mayanghe Nature Reserve, Guizhou, People's Republic of China. To estimate the range and predict suitable habitat of François' langur, a Gaussian normal kernel density estimation and species distribution models (BIOMOD2) were used along with data on environmental variables and records of the langur's occurrence.