CXCL14 as a potential marker for immunotherapy response prediction in renal cell carcinoma.

Background: Epigenetic mechanisms play vital roles in the activation, differentiation, and effector function of immune cells. The breast and kidney-expressed chemokine (CXCL14) mainly contributes to the regulation of immune cells. However, its role in shaping the tumor immune microenvironment (TIME) is yet to be elucidated in renal cell carcinoma (RCC).

Genomic Characteristics and Single-Cell Profiles After Immunotherapy in Fumarate Hydratase-Deficient Renal Cell Carcinoma.

Purpose: Fumarate hydratase-deficient renal cell carcinoma (FHRCC) is highly malignant, but the urgent need for effective treatment remains unmet. We aimed to analyze the genomic characteristics and microenvironment of FHRCC and the cause of heterogeneous response to immune checkpoint inhibitor (ICI)-based treatment at single-cell level.

Experimental Design: Whole-exome sequencing and IHC staining analyses were performed in 30 advanced FHRCC patients.

Transparent nanocrystal-in-glass composite fibers for multifunctional temperature and pressure sensing.

The pursuit of compact and integrated devices has stimulated a growing demand for multifunctional sensors with rapid and accurate responses to various physical parameters, either separately or simultaneously. Fluorescent fiber sensors have the advantages of robust stability, light weight, and compact geometry, enabling real-time and noninvasive signal detection by monitoring the fluorescence parameters. Despite substantial progress in fluorescence sensors, achieving multifunctional sensing in a single optical fiber remains challenging.

Coupling Localized Laser Writing and Nonlocal Recrystallization in Perovskite Crystals for Reversible Multidimensional Optical Encryption.

The ability to generate and manipulate photoluminescence (PL) with high spatial resolution has been of primary importance for applications in micro-optoelectronics, while the emerging metal halide perovskites offer novel material platforms where diverse photonic functionalities and fine structuring are constantly explored. Herein, micro-PL patterns consisting of highly luminescent CsPbBr nanocrystals (NCs) in nonluminescent perovskite crystals are directly fabricated by focused femtosecond laser irradiation. Further modulation with a moisture field leads to the selective dissolution of the laser-destabilized perovskite structures as revealed by density functional theory simulations, thus allowing for facile control of the reversible PL from the recrystallization of moisture-induced CsPbBr NCs.

Concise Nanoplatform of Phycocyanin Nanoparticle Loaded with Docetaxel for Synergetic Chemo-sonodynamic Antitumor Therapy.

Combined chemotherapy and sonodynamic therapy (chemo-SDT) based on the nanoplatform/nanocarrier is a potential antitumor strategy that has shown higher therapeutic efficacy than any monotherapy. Therefore, a safe and effective multifunctional system with a concise design and simple preparation process is urgently needed. In this work, by using a one-step cross-linking method, a multifunctional nanosystem, which employs phycocyanin nanoparticles (PCNPs) as a nanocarrier to deliver the chemotherapy drug docetaxel (DTX) and a nanosonosensitizer to generate reactive oxygen species (ROS), was prepared and evaluated (PCNP-DTX).

CircSAMD11 facilitates progression of cervical cancer via regulating miR-503/SOX4 axis through Wnt/β-catenin pathway.

Cervical cancer (CC) is a common gynaecological malignant tumour with a high mortality rate. Circular RNAs (circRNAs) play a critical role in tumour occurrence and development. This study aimed to investigate the function and molecular basis of hsa_circ_0009189 (circSAMD11) in CC development.

Phycocyanin Nanoparticle as a Novel Sonosensitizer for Tumor Sonodynamic Therapy of Michigan Cancer Foundation-7 Cells .

The development of novel sonosensitizers with safety and efficiency is a key problem in anti-tumor sonodynamic therapy. Phycocyanin (PC) has been proved to have the singlet oxygen radicals (ROS) generation ability, and the potential of PC as a novel sonosensitizer has been investigated. To overcome the disadvantages of PC , such as poor stability and low half-life, PC nanoparticles (PCNP) were prepared by the cross-linking method.

Insights into Synergistic Effect of Acid on Morphological Control of Vanadium Oxide: Toward High Lithium Storage.

Morphological control is a fundamental challenge of nanomaterial development. Commonly, hierarchical nanostructures cannot be induced by a single driving force, but obtained through balancing multiple driving forces. Here, a feasible strategy is reported based on the synergistic effect of proton and acid anion, leading to the morphological variation of vanadium oxide from nanowire, bundle, to hierarchical nanoflower (HNF).

Carbapenems vs alternative antibiotics for the treatment of complicated urinary tract infection: A systematic review and network meta-analysis.

Background: Complicated urinary tract infections (cUTI) are universal reasons for hospitalization, and highly likely to develop into sepsis or septic shock. Carbapenem antibiotics with potentially higher efficacy or with fewer and milder side effects have increased in popularity, but evidence is limited by a scarcity of randomized controlled trials (RCTs) comparing different carbapenem antibiotics for cUTI. Network meta-analysis is a useful tool to compare multiple treatments when there is limited or no direct evidence available.

Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy.

Diabetic cardiac autonomic neuropathy (DCAN) is a common and serious complication of diabetes mellitus (DM), is manifested by nerve fiber injury in the sympathetic and parasympathetic nerve of the autonomic nervous system, and causes hypertension, cardiac arrhythmias, silent myocardial infarction, and sudden death. Our previous study observed that P2X3 receptor in superior cervical ganglia in rat was associated with sympathetic neuropathy caused by myocardial ischemia. However, whether the P2X3 receptor is involved in the diabetic cardiac autonomic neuropathy and the underlying mechanisms remain unclear.

Spectroscopic properties in Er-doped germanotellurite glasses and glass ceramics for mid-infrared laser materials.

Transparent Er-doped germanotellurite glass ceramics (GCs) with variable Te/Ge ratio were prepared by controllable heat-treated process. X-ray diffraction (XRD) and transmission electron microscope (TEM) confirmed the formation of nanocrystals in glass matrix. Raman spectra were used to investigate the evolution of glass structure and photon energy.

Regulating Mid-infrared to Visible Fluorescence in Monodispersed Er-doped LaOS (LaOSO) Nanocrystals by Phase Modulation.

Rare earth doped mid-infrared (MIR) fluorescent sources have been widely investigated due to their various potential applications in the fields of communication, chemical detecting, medical surgery and so forth. However, with emission wavelength extended to MIR, multiphonon relaxation process that strongly quenched the MIR emission is one of the greatest challenges for such practical applications. In our design, we have described a controllable gas-aided annealing strategy to modulate the phase, crystal size, morphology and fluorescent performance of a material simultaneously.

Controllable Synthesis of Monodisperse Er-Doped Lanthanide Oxyfluorides Nanocrystals with Intense Mid-Infrared Emission.

Monodisperse lanthanide oxyfluorides LnOF (Ln = Gd, Y) with mid-infrared emissions were controllably synthesized via a mild co-precipitation route and a subsequent heat-treatment. The detailed composition and morphology were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and high resolution transmission electron microscopy (HRTEM). The results showed that monodisperse GdOF:Er were nano-riced shape with length about 350 nm and width about 120 nm, while the quasi-spherical YOF:Er were uniform nanocrystals with an average size around 100 nm.

Controllable Phase Transformation and Mid-infrared Emission from Er(3+)-Doped Hexagonal-/Cubic-NaYF4 Nanocrystals.

The morphology of hexagonal phase NaYF4:Er(3+) nanorods synthesized by hydrothermal method changed greatly after a continuing calcination, along with a phase transformation to cubic phase. Photoluminescence (PL) spectra indicated that mid-infrared (MIR) emission was obtained in both hexagonal and cubic phase NaYF4:Er(3+) nanocrystals for the first time. And the MIR emission of NaYF4:Er(3+) nanocrystals enhanced remarkably at higher calcination temperature.

Controllable Synthesis and Peculiar Optical Properties of Lanthanide-Doped Fluoride Nanocrystals.

Yb /Tm -codoped NaYF nanocrystals with different phases (cubic α and hexagonal β) and morphologies (nanoparticles, nanorods, nanoplates) have been controllably fabricated by a convenient hydrothermal synthesis technique. Up-conversion emission peaks were observed at λ=450, 475, 645, and 700 nm, which were assigned to the D - F , G - H , G - F , and F - H transitions of Tm ions, respectively. By using a homemade detection system, the anisotropic polarized emission properties of individual NaYF :Yb, Tm nanorods and nanoplates were investigated.

Synthesis and luminescence mechanism of multicolor-emitting g-C3N4 nanopowders by low temperature thermal condensation of melamine.

Graphite like C3N4 (g-C3N4) was synthesized facilely via the low temperature thermal condensation of melamine between 300-650°C. The results showed that the products maintained as melamine when the temperature is below 300°C. With the increase of temperature, the products were transformed into carbon nitride and amorphous g-C3N4 successively.