Publications by authors named "Qiuyue Lai"
Article Synopsis
- There is an urgent need for effective treatments for liver fibrosis, which require targeted delivery of antifibrotic drugs to activated hepatic stellate cells (aHSCs) due to challenges posed by collagen buildup.
- The study created nanoparticle formulations (SF-siHSP47@VFPL NPs) that co-deliver the antifibrotic drug sorafenib and siRNA, leveraging vitamin A to enhance delivery efficiency to aHSCs by targeting their receptors.
- In mouse models, these nanoparticles not only reduced liver fibrosis markers and promoted healing but also demonstrated strong antifibrotic effects by inducing cell death mechanisms, showcasing their potential for innovative treatment strategies in liver fibrosis.
Article Synopsis
- - The study explores photodynamic therapy (PDT) enhanced by an aggregation-induced emission photosensitizer (AIE-PS), which is limited by high levels of reduced glutathione (GSH) in tumor cells that can reduce its effectiveness.
- - A novel nanodelivery system was developed using albumin to carry AIE-PS and Sorafenib, with disulfide linkers creating a nanogel core and cancer cell membranes wrapped on the surface for targeted delivery.
- - The approach aims to disrupt redox balance by inhibiting GSH synthesis and utilizing disulfide bonds to deplete GSH, thereby increasing reactive oxygen species (ROS) levels in cancer cells, enhancing the effectiveness of PDT and leading
Antiangiogenic therapy with sorafenib (SF) alone is ineffective in eradicating tumors, and its long-term application can exacerbate tumor hypoxia, which in turn restricts SF's therapeutic efficacy. Here, a redox-responsive fluorinated peptide (DEN-TAT-PFC) consisting of dendritic poly-lysine, cell-penetrating peptide TAT, and perfluorocarbon was designed and synthesized to co-load siRNA-targeting hypoxia-inducible factors (siHIF-1α) and SF. The unique architecture of the peptide and fluorinated modifications enhanced the siRNA delivery efficiency, including increased siRNA binding, GSH-responsive release, cellular uptake, endosomal escape, and serum resistance.
View Article and Find Full Text PDFAdvances in cell-penetrating poly(disulfide)s for intracellular delivery of therapeutics.
Drug Discov Today
August 2023
Efficient intracellular delivery is essential for most therapeutic agents; however, existing delivery vectors face a dilemma between efficiency and toxicity, and always encounter the challenge of endolysosomal trapping. The cell-penetrating poly(disulfide) (CPD) is an effective tool for intracellular delivery, as it is taken up through thiol-mediated cellular uptake, thus avoiding endolysosomal entrapment and ensuring efficient cytosolic availability. Upon cellular uptake, CPD undergoes reductive depolymerization by glutathione inside cells and has minimal cytotoxicity.
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