Publications by authors named "Qiuyu Wen"
Background: The pseudo germ-free (PGF) model has been widely used to research the role of intestinal microbiota in drug metabolism and efficacy, while the modelling methods and the utilization of the PGF model are still not standardized and unified. A comprehensive and systematic research of the PGF model on the composition and function of the intestinal microbiota, changes in host cytochrome P450 (CYP450) enzymes expression and intestinal mucosal permeability in four different modelling cycles of the PGF groups are provided in this paper.
Results: 16S rRNA gene amplicon sequencing was employed to compare and analyze the alpha and beta diversity, taxonomic composition, taxonomic indicators and predicted function of gut microbiota in the control and PGF groups.
Amygdalin (Amy) is metabolized into cyanide , which may lead to fatal poisoning after oral administration. The defense mechanisms against toxic cyanide have not yet been adequately studied. In this study, comparative toxicokinetics study of Amy was performed in normal and pseudo germ-free rats.
View Article and Find Full Text PDFArticle Synopsis
- Different people have different reactions to azathioprine (AZA) because their bodies make different amounts of two important substances from it called 6-TGN and 6-MMP.
- The study looked at how these substances behave in two groups of rats, one with normal gut bacteria and one that was mostly free of bacteria (called pseudo germ-free or PGF).
- It was found that the PGF group had less 6-TGN and 6-MMP compared to the normal group, suggesting that gut bacteria might help break down AZA and affect how much of it is in the body.
Mahuang-Xingren (MX, Stapf- L.) is a classic herb pair used in traditional Chinese medicine. This combined preparation reduces the toxicity of Xingren through the stereoselective metabolism of its amygdalin.
View Article and Find Full Text PDF