Effectiveness of HIV health education interventions on the MSM population: a meta-analysis.

Men who have sex with men (MSM) face a heightened risk of HIV, presenting a significant public health issue. This meta-analysis evaluates the effectiveness of HIV health education for MSM by examining changes in knowledge, attitudes, and behaviors across different cultures and regions. The study also explores heterogeneity sources through subgroup and sensitivity analyses to guide future research.

Controlling Self-Oscillation of a Single-Layer Liquid Crystal Elastomer at the Air-Water Interface via Light Programming for Water Strider-Inspired Aquatic Robots.

Biomimicking aquatic organisms offers many opportunities for designing intelligent robots that can freely move on water. However, most works were focused on multilayered materials or assembled structures and faced limitations in stability, versatility, and motion navigation. Here, we develop an assembly-free water-strider-like aquatic robot using a single layer of light-programmable liquid-crystal elastomer (LCE) that could be used to create asymmetric structures.

Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation.

Ulcerative colitis (UC) is a heterogeneous autoimmune condition. PANoptosis, a new form of programmed cell death, plays a role in inflammatory diseases. This study aimed to identify differentially expressed PANoptosis-related genes (PRGs) involved in immune dysregulation in UC.

EEG-based fatigue state evaluation by combining complex network and frequency-spatial features.

Background: The proportion of traffic accidents caused by fatigue driving is increasing year by year, which has aroused wide concerns for researchers. In order to rapidly and accurately detect drivers' fatigue, this paper proposed an electroencephalogram (EEG)-based fatigue state evaluation method by combining complex network and frequency-spatial features.

New Method: First, this paper constructed a complex network model based on the relative wavelet entropy to characterize the correlation strength information between channels.

The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana).

Bullfrogs (Aquarana catesbeiana) are increasingly cultivated for their high nutritional value and adaptability to intensive aquaculture systems. However, ensuring optimal intestinal health and growth performance remains a challenge due to poor water quality and high stocking densities. This study evaluated the effects of varying dietary concentrations of citral, a natural compound from lemongrass essential oil, on the intestinal health, microbiota, antioxidant capacity, and growth performance of juvenile bullfrogs.

Efficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation.

Purpose: To evaluate the efficacy, durability and safety of intravitreal faricimab versus aflibercept over 48 weeks in patients with neovascular age-related macular degeneration (nAMD) from the LUCERNE China subpopulation.

Design: LUCERNE (NCT03823300) was a phase 3 global, double-masked, active comparator-controlled trial. The China subpopulation comprised patients from mainland China, Taiwan and Hong Kong.

Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.

Sigal peptides have garnered remarkable efficacy in rejuvenating photoaged skin and delaying senescence. Nevertheless, their low solubility and poor permeability bring about a formidable challenge in their transdermal delivery. To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared.

An EEG-based emotion recognition method by fusing multi-frequency-spatial features under multi-frequency bands.

Background: Recognition of emotion changes is of great significance to a person's physical and mental health. At present, EEG-based emotion recognition methods are mainly focused on time or frequency domains, but rarely on spatial information. Therefore, the goal of this study is to improve the performance of emotion recognition by integrating frequency and spatial domain information under multi-frequency bands.

Identification of VDAC1 as a cardioprotective target of Ginkgolide B.

Ginkgolide B (GB), a compound derived from Ginkgo biloba, exhibits significant cardioprotective properties, although its precise molecular target has yet to be identified. In this study, we synthesized a biotin-labeled GB probe (GB-biotin) to identify the molecular targets of GB. Our experiments demonstrated that treatment with GB or GB-biotin reduced mitochondrial injury, restored mitochondrial membrane potential, and decreased cell apoptosis in a concentration-dependent manner.

Physiological Responses of Juvenile Bullfrogs () to Salinity Stress.

Bullfrogs () are increasingly farmed for their high nutritional value and adaptability to intensive aquaculture systems. However, salinity stress due to environmental changes and habitat salinization poses a significant challenge for both wild and farmed bullfrogs. This study examines the physiological responses of juvenile bullfrogs to varying salinity levels (0, 2, 4, 6 ppt) to better understand their capacity for osmoregulation and adaptation to salinization.

The Composition and Function of Intestinal Microbiota Were Altered in Farmed Bullfrog Tadpoles () during Metamorphosis.

The bullfrog is one of the main farmed frog species in China, with a low overall survival of farmed bullfrogs from hatching to harvest since bullfrog tadpoles are fragile during the metamorphosis period. The intestinal bacterial community can play crucial roles in animal development; however, little is known about the alteration of the gut microbial community of during metamorphosis. The present study used 16S rRNA amplicon sequencing to investigate the intestinal bacterial community in at four distinct developmental stages.

Environmental dependency of ectomycorrhizal fungi as soil organic matter oxidizers.

Forest soils play a pivotal role as global carbon (C) sinks, where the dynamics of soil organic matter (SOM) are significantly influenced by ectomycorrhizal (ECM) fungi. While correlations between ECM fungal community composition and soil C storage have been documented, the underlying mechanisms behind this remain unclear. Here, we conducted controlled experiments using pure cultures growing on naturally complex SOM extracts to test how ECM fungi regulate soil C and nitrogen (N) dynamics in response to varying inorganic N availability, in both monoculture and mixed culture conditions.

PiRNA CFAPIR inhibits cardiac fibrosis by regulating the muscleblind-like protein MBNL2.

Myocardial fibroblasts transform into myofibroblasts during the progression of cardiac fibrosis, together with excessive cardiac fibroblast proliferation. Hence, the prevention and treatment of cardiac fibrosis are significant factors for inhibiting the development of heart failure. P-element Induced WImpy testis-interacting RNAs (PiRNA) are widely expressed in the heart, but their involvement in cardiac fibrosis has not yet been confirmed.

Therapeutic potential of adipose-derived stem cell extracellular vesicles: from inflammation regulation to tissue repair.

Inflammation is a key pathological feature of many diseases, disrupting normal tissue structure and resulting in irreversible damage. Despite the need for effective inflammation control, current treatments, including stem cell therapies, remain insufficient. Recently, extracellular vesicles secreted by adipose-derived stem cells (ADSC-EVs) have garnered attention for their significant anti-inflammatory properties.

The trend analysis of HIV and other sexually transmitted infections among the elderly aged 50 to 69 years from 1990 to 2030.

Background: The HIV and other sexually transmitted infections (STI) excluding HIV among the elderly population urgently require more attention and in-depth study. We aimed to present and predict the worldwide of its burden from 1990 to 2030 using data from the Global Burden of Disease (GBD) study.

Methods: Leveraging the 2019 GBD study, we investigated the average annual percentage change (AAPC) of HIV and other STI in incidence, prevalence, disability-adjusted life years (DALYs), and mortality rates for individuals aged 50-69 across different age groups, genders, sociodemographic index (SDI) regions, and nations.

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-induced Nausea and Vomiting.

Chemotherapy-induced nausea and vomiting (CINV) refers to the nausea and vomiting experienced by patients after the application of chemotherapy drugs, significantly affecting their quality of life and physical recovery, as well as increasing the pain of the patients. Basic medicine primarily focuses on acid suppression, gastric protection, and vomiting suppression, but there are still many patients with nausea and vomiting symptoms that cannot be alleviated. Traditional Chinese medicine (TCM) can effectively alleviate nausea and vomiting through acupoint stimulation and pressure, while also offering advantages such as simplicity, affordability, and fewer side effects.

MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.

Aging-related cardiac fibrosis represents the principal pathological progression in cardiovascular aging. The Muscleblind-like splicing regulator 2 (MBNL2) has been unequivocally established as being associated with cardiovascular diseases. Nevertheless, its role in aging-related cardiac fibrosis remains unexplored.

Modelling Food Substitution Using the Ofcom Nutrient Profiling Model on Population Intakes from the Canadian Community Health Survey-Nutrition 2015.

This study aimed to model how substituting foods consumed by Canadians for alternatives with more favourable nutrient profiling (NP) scores would impact dietary intakes. The Ofcom NP system, developed to help the UK Office of Communication differentiate foods that can be advertised to children, was applied to foods consumed by Canadians aged 2 years and older in the 2015 Canadian Community Health Survey (CCHS) ( = 19,447). Foods were substituted for similar options from the Euromonitor branded food composition database (Scenario 1) or from the primarily aggregated food profiles in the CCHS survey food composition database (Scenario 2) with either the most favourable (optimistic; 1A and 2A) or a more favourable Ofcom score (realistic; 1B and 2B).

Examining the association of hysterectomy with and without oophorectomy on cardiovascular disease and all-cause, cardiovascular or cancer mortality: A systematic review and meta-analysis.

Background: The associations between hysterectomy and cardiovascular disease (CVD) and mortality remains unlcear and a meta-analysis with cohort studies is lacking.

Objectives: This study aimed to conduct a systematic review and meta-analysis of cohort studies to investigate the relationship between hysterectomy and CVD, coronary heart disease (CHD), stroke, heart failure, and all-cause, cardiovascular and cancer mortality. We further explored the effect of oophorectomy on the association between hysterectomy and these health outcomes.

Internal loading regulates the phosphorus concentration in a diversion input shallow lake in the semi-humid region of North China: Differentiated processes in littoral wetland and open water areas.

Diversion input lakes usually have a low catchment area/lake area ratio and pulsing pollution input. Various pollutants might accumulate in the lake continuously owing to the concentration effect under high evaporation but low precipitation over the entire area, typically for sedimentary cyclic elements such as phosphorus (P). However, the detailed transportation, sedimentation, and internal release mechanisms of P in the diversion input lakes remain unclear.

Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification.

Many immune-mediated diseases have the common genetic basis, as an autoimmune disorder, celiac disease (CeD) primarily affects the small intestine, and is caused by the ingestion of gluten in genetically susceptible individuals. As for ulcerative colitis (UC), which most likely involves a complex interplay between some components of the commensal microbiota and other environmental factors in its origin. These two autoimmune diseases share a specific target organ, the bowel.