Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis.

Background: We investigated the corneal biomechanical properties and their genotype-phenotype correlation correlations in patients with Marfan syndrome (MFS) and ectopia lentis (EL).

Methods: Patients with MFS with EL underwent panel-based next-generation sequencing in this retrospective cohort study. The FBN1 genotypes were categorized into the dominant-negative (DN) group and the haploinsufficiency (HI) group.

Genetic landscape and ocular biometric correlations in microspherophakia: insights from a comprehensive patient cohort.

Aims: The aim of this study is to elucidate the genetic landscape of microspherophakia (MSP) and describe the genotype-phenotype correlation of MSP. Additionally, the study seeks to enhance the understanding of the pathogenic mechanisms of MSP through the discovery of novel loci.

Methods: Patients diagnosed with MSP at the Eye and ENT Hospital of Fudan University, Shanghai, were included in the study and all underwent panel-based next-generation sequencing and bioinformatics analysis.

Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis.

Purpose: The purpose of this study was to develop an artificial intelligence (AI)-based intraocular lens (IOLs) power calculation formula for improving the accuracy of IOLs power calculations in patients with congenital ectopia lentis (CEL).

Methods: A total of 651 eyes with CEL that underwent IOLs implantation surgery were included in this study. An AI-based ensemble formula-the Jiang Formula, was developed using a training dataset of 520 eyes and evaluated on a testing dataset of 131 eyes.

Corrigendum: Clinical ocular prediction model of postoperative ametropic amblyopia in patients with congenital ectopia lentis.

[This corrects the article DOI: 10.3389/fmed.2024.

Improving the accuracy of lens formulas for in-the-bag intraocular lens implantation in Marfan syndrome patients with ectopia lentis.

Purpose: To improve the accuracy of intraocular lens (IOL) power calculation formulas by modifying the effective lens position (ELP) equations for patients with Marfan syndrome (MFS) and ectopia lentis (EL) undergoing in-the-bag IOL implantation.

Setting: Eye and ENT Hospital of Fudan University, Shanghai, China.

Design: Retrospective cohort study.

Clinical ocular prediction model of postoperative ametropic amblyopia in patients with congenital ectopia lentis.

Introduction: Despite prompt and appropriate surgical management, a considerable proportion of patients with congenital ectopia lentis (CEL) suffer from postoperative ametropic amblyopia. To predict and identify at-risk patients early, and ensure timely amblyopia treatment, we conducted a thorough investigation into the onset and progression patterns of postoperative amblyopia in patients with CEL. Moreover, an ocular prediction model was constructed for amblyopia.

Genotype Associated With Visual Prognosis in Patients With Congenital Ectopia Lentis Following Lens Surgery: A Prospective Cohort Study.

Purpose: To investigate the relationship between visual prognosis and genotype in patients undergoing lens surgery for congenital ectopia lentis (EL).

Design: Prospective clinical cohort study.

Methods: Patients with congenital EL who underwent lens removal and intraocular lens implantation received panel-based next-generation sequencing.

4D label-free proteomic analysis of vitreous from patients with rhegmatogenous retinal detachment.

Aim: To identify metabolites, proteins, and related pathways involved in the etiology of rhegmatogenous retinal detachment (RRD) for use as biomarkers in diagnosing and treating RRD.

Methods: Vitreous specimens were collected and liquid chromatography-tandem mass spectrometry analysis was performed using the four-dimensional label-free technique. Statistically significant differentially expressed proteins, gene ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway representations, and protein interactions were analyzed.

Corrigendum to "Polydopamine/poly(sulfobetaine methacrylate) Co-deposition coatings triggered by CuSO4/H2O2 on implants for improved surface hemocompatibility and antibacterial activity" [ Bioactive materials 6 (2021) 2546-2556].

[This corrects the article DOI: 10.1016/j.bioactmat.

Drug-free contact lens based on quaternized chitosan and tannic acid for bacterial keratitis therapy and corneal repair.

Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were used to construct a novel antibacterial and antioxidant contact lens. The obtained hydrogels showed high water content (>85%), swelling resistance, light transmittance (>90%) and adjustable mechanical property.

Clinical Accuracy of 6 Intraocular Lens Power Calculation Formulas in Elongated Eyes, According to Anterior Chamber Depth.

Purpose: To investigate the influence of anterior chamber depth (ACD) on the accuracy of the Kane, EVO 2.0, Barrett Universal II (BU II), Olsen, SRK/T, and Haigis formulas in patients with elongated eyes.

Design: Retrospective case series study.

Polydopamine/poly(sulfobetaine methacrylate) Co-deposition coatings triggered by CuSO/HO on implants for improved surface hemocompatibility and antibacterial activity.

Implanted biomaterials such as medical catheters are prone to be adhered by proteins, platelets and bacteria due to their surface hydrophobicity characteristics, and then induce related infections and thrombosis. Hence, the development of a versatile strategy to endow surfaces with antibacterial and antifouling functions is particularly significant for blood-contacting materials. In this work, CuSO/HO was used to trigger polydopamine (PDA) and poly-(sulfobetaine methacrylate) (PSBMA) co-deposition process to endow polyurethane (PU) antibacterial and antifouling surface (PU/PDA(Cu)/PSBMA).