The Amorphous Solid Dispersion of Chrysin in Plasdone S630 Demonstrates Improved Oral Bioavailability and Antihyperlipidemic Performance in Rats.

Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render its oral bioavailability rather poor. This study aimed to develop a stable solid dispersion formulation of chrysin to improve the dissolution of chrysin, so as to increase its oral bioavailability and improve its antihyperlipidemic activities.

A New Spatial Registration Algorithm of Aerial Moving Platform to Sea Target Tracking.

Spatial registration is the primary challenge affecting target tracking accuracy, especially for the aerial moving platform and sea target tracking. In this environment, it is important to account for both the errors in sensor observations and the variations in platform attitude. In order to solve the problem of complex types of errors in the tracking of sea targets by aerial moving platforms, a new spatial registration algorithm is proposed.

Using Self-Nanoemulsifying System to Improve Oral Bioavailability of a Pediatric Antiepileptic Agent Stiripentol: Formulation and Pharmacokinetics Studies.

This study aimed to develop a self-nanoemulsifying drug delivery system (SNEDDS) for poorly water-soluble drug stiripentol (STP) with enhanced oral bioavailability. Optimal excipients were selected by constructing pseudo-ternary phase diagrams using determined solubilities of STP, and then the proper composition of SNEDDS was investigated by employing a central composite design method. The optimized SNEDDS was composed of oil (ethyl oleate 39.