Publications by authors named "Qiuxia Gu"
Background: MASH is a common clinical disease that can lead to advanced liver conditions, but no approved pharmacotherapies are available due to an incomplete understanding of its pathogenesis. Damaged DNA binding protein 1 (DDB1) participates in lipid metabolism. Nevertheless, the function of DDB1 in MASH is unclear.
View Article and Find Full Text PDFIncreasing evidence indicated that mitophagy might play a crucial role in the occurrence and progression of liver diseases. In order to enhance our understanding of the intricate relationship between mitophagy and liver diseases, a comprehensive bibliometric analysis of the existing literature in this field was conducted. This analysis aimed to identify key trends, potential areas of future research, and forecast the development of this specific field.
View Article and Find Full Text PDFLiver resection is the first-line treatment for primary liver cancers, providing the potential for a cure. However, concerns about post-hepatectomy liver failure (PHLF), a leading cause of death following extended liver resection, have restricted the population of eligible patients. Here, we engineered a clinical-grade bioartificial liver (BAL) device employing human-induced hepatocytes (hiHeps) manufactured under GMP conditions.
View Article and Find Full Text PDFArticle Synopsis
- Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease, and recent studies highlight the potential role of circular RNAs, specifically mitochondria-encoded circRNAs (mecciRNAs), in its progression.
- Using various gene expression databases and analysis techniques, the study investigated differentially expressed mecciRNAs in NASH, their interaction with other RNAs, and identified immune subtypes of the disease.
- The research revealed that specific mecciRNAs can act as competing endogenous RNAs, influencing fibrosis-related signals and leading to the identification of 21 core genes, indicating distinct clusters among NASH patients based on their inflammatory signals.
Background: It has been demonstrated that simultaneous resection of both primary colorectal lesion and metastatic hepatic lesion is a safe approach with low mortality and postoperative complication rates. However, there are some controversies over which kind of surgical approach is better. The aim of study was to compare the efficacy and safety of laparoscopic surgeries and open surgeries for simultaneous resection of colorectal cancer (CRC) and synchronous colorectal liver metastasis (SCRLM).
View Article and Find Full Text PDFBackground: Laparoscopic liver resection has increased rapidly and procedure has almost extended to all the types of liver resection. Major liver resections, such as hemihepatectomies, were still innovative procedures in the exploration phase and continued cautious introduction of major laparoscopic liver resections was recommended by experts. The study aims to evaluate the safety of laparoscopic hemihepatectomy (LH) by the comparing with open hemihepatectomy (OH).
View Article and Find Full Text PDFBackground: The mTOR pathway is vital for homeostasis, metabolism, cancer transplantation and regeneration in the liver. The aim of this study is to use a bibliometric method to reveal current research hotspots and promising future trends in mTOR signaling in liver diseases.
Methods: Publications were searched and downloaded from the Web of Science Core Collection (WOSCC) Database.