Preparation and Characterization of Small-Size and Strong Antioxidant Nanocarriers to Enhance the Stability and Bioactivity of Curcumin.

The purpose of this study was to design nanocarriers with small-size and antioxidant properties for the effective encapsulation of curcumin. Here, procyanidins, vanillin, and amino acids were used to successfully prepare nanocarriers of a controllable size in the range of 328~953 nm and to endow antioxidant ability based on a one-step self-assembly method. The reaction involved a Mannich reaction on the phenolic hydroxyl groups of procyanidins, aldehyde groups of vanillin, and amino groups of amino acids.

Weizmannia coagulans BC99 affects valeric acid production via regulating gut microbiota to ameliorate inflammation and oxidative stress responses in Helicobacter pylori mice.

Helicobacter pylori is a highly prevalent pathogen in human gastric mucosa epithelial cells with strong colonization ability. Weizmannia coagulans is a kind of active microorganism that is beneficial to the improvement of host gut microbiota balance and can prevent and treat intestinal diseases. We investigated the beneficial effects of W.

Effect of heat treatment on microstructure and mechanical properties of selective laser melted Inconel 718 alloy.

In this study, we conducted two heat treatment processes, namely double aging (DA) and solid solution followed by double aging (SA), on the Inconel 718 alloy fabricated by selective laser melting (SLM). The aim was to investigate the microstructure evolution and mechanical properties of Inconel 718 under different heat treatment conditions. To achieve this, we employed advanced techniques such as Scanning Electron Microscope (SEM), electron backscattered diffraction (EBSD), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), Tofwerk time-of-flight secondary ion mass spectrometer (TOF-SIMS), and transmission electron microscopy (TEM).

Clinical characteristics and prognosis of SARS-CoV-2 infection in children with hematological malignancies: A multicenter, retrospective study in China.

Background: Data on SARSCoV-2 infection in children with hematological malignancies (HM) are limited. Here, we describe the clinical features of children with HM after SARS-CoV-2 infection and investigate the potential risk factors for disease severity.

Methods: Children with HM and SARS-CoV-2 infection from five hospitals in five cities in Henan, China from October 2022 to January 2023 were retrospectively included.

Antibacterial properties of hexanal-chitosan nanoemulsion against Vibrio parahaemolyticus and its application in shelled shrimp preservation at 4 °C.

Vibrio parahaemolyticus has been considered as the leading pathogen associated with seafood-borne disease. Hexanal possesses antibacterial property but the hydrophobicity and volatility limit its application. The purpose of this study was to prepare hexanal-chitosan nanoemulsion (HCN), investigate its antibacterial ability against V.

The combination model of CNN and GCN for machine fault diagnosis.

Learning powerful discriminative features is the key for machine fault diagnosis. Most existing methods based on convolutional neural network (CNN) have achieved promising results. However, they primarily focus on global features derived from sample signals and fail to explicitly mine relationships between signals.

TMT-Based Quantitative Proteomics and Non-targeted Metabolomic Analyses Reveal the Antibacterial Mechanism of Hexanal against .

Hexanal is a phytochemical with antimicrobial activity. However, its antibacterial effect and mechanism against () remain unclear. The study aims to elucidate the associated mechanism using tandem mass tag quantitative proteomics and non-targeted metabolomics.

Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center.

Introduction: Recent studies report that latent tuberculosis infection (LTBI) may lead to an increased risk of cardiovascular disease (CVD) that led us to hypothesize that LTBI may play an important role in major adverse cardiovascular events (MACE) in dialysis patients.

Methods: A single-center retrospective cohort study was conducted. A total of 270 patients undergoing hemodialysis or peritoneal dialysis more than 3 months were included.

A study on pick cutting properties with full-scale rotary cutting experiments and numerical simulations.

To investigate the cutting forces on road-header picks, a series of full-scale single-pick rotary cutting tests on sandstone samples were conducted at the National Engineering Laboratory of Coal Mining Machinery and Equipment, China. The primary objective of this study is to optimize the cut spacing and to verify the numerical simulation results. Cutting forces are investigated under different cutting depths and cut spacings.

Inhibitory effects of lactobionic acid on Vibrio parahaemolyticus planktonic cells and biofilms.

Vibrio parahaemolyticus is the primary pathogenic bacteria associated with seafood-borne illnesses. Lactobionic acid (LBA) is an organic acid with multiple biological activities that has recently been a focus of interest as an antibacterial agent. The aim of this study was to investigate the inhibitory effects of LBA on Vibrio parahaemolyticus planktonic cells and biofilms.

dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity.

Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how proteostasis is regulated in different tissues throughout the aging process remains unclear.

Value of gamma interferon enzyme-linked immunospot assay in the diagnosis of peritoneal dialysis-associated tuberculous peritonitis.

Background: Tuberculous peritonitis is the most common form of extrapulmonary tuberculosis infection in peritoneal dialysis patients. However, diagnosing tuberculous peritonitis quickly and early has always been a challenge for nephrologists. Mycobacterium tuberculosis antigen-specific gamma interferon enzyme-linked immunospot (IFN-γ ELISPOT) assay has been widely used in the clinical diagnosis of tuberculous pleurisy and peritonitis, but its use has not been reported for uremia.

Inactivation Effect of Thymoquinone on Vegetative Cells, Spores, and Biofilms.

(), a spore-forming bacterium, has become a main challenge and concern for the juices and acid beverage industry across the world due to its thermo-acidophilic characteristic. Thymoquinone (TQ) is one of the active components derived from seeds. The objective of this study was to investigate antibacterial activity and associated molecular mechanism of TQ against vegetative cells, and to evaluate effects of TQ on spores and biofilms formed on polystyrene and stainless steel surfaces.

Antimicrobial and anti-biofilm activity of thymoquinone against Shigella flexneri.

Shigella flexneri (Sh. flexneri), a common foodborne pathogen, has become one of the main threats to food safety and human health due to its high pathogenicity and persistent infection. The objective of this study was to explore the antimicrobial and anti-biofilm activities and the possible mechanism of thymoquinone (TQ) against Sh.

Efficient circular gene knockout system for Burkholderiales strain DSM 7029 and Mycobacterium smegmatis mc2 155.

Multiple gene knockouts are often employed in studies of microbial physiology and genetics. However, the selective markers that confer antibiotic resistance are generally limited, so it is necessary to remove these resistance genes before the next round of using, which is time consuming and labor intensive. Here, we created a universal circular gene knockout system for both the gram-negative bacterial Burkholderiales strain DSM 7029 and the gram-positive bacterial Mycobacterium smegmatis mc2 155, by combining the homologous recombination with multiple serine integrase-meditated site-specific recombination systems.

Inhibitory Effect of Coenzyme Q0 on the Growth of .

Coenzyme Q0 (CoQ0), one of benzoquinone compounds, has been demonstrated to possess antineoplastic, anti-inflammatory and antioxidant activities. However, its antimicrobial effect has not been extensively reported. In this study, antimicrobial activity of CoQ0 against was evaluated by measurement of inhibition zone, minimum inhibitory concentration (MIC), and growth curves.

Immune Thrombocytopenic Purpura in Children of Eastern Henan Province, China.

In this retrospective cohort study conducted in 63 children with idiopathic thrombocytopenic purpura (ITP) in China; petechiae, bruises and bleeding were the major presentations. Most cases required therapy with one/more treatment options.