Inhalable multi-stimulus sensitive curcumin-alginate nanogels for scavenging reactive oxygen species and anti-inflammatory co-ordination to alleviate acute lung injury.

Acute lung injury (ALI) is one of the most common and extremely critical clinical conditions, which progresses with an inflammatory response and overproduction of reactive oxygen species (ROS), leading to oxidative damage to the lungs. Curcumin (Cur) has great potential in treating ALI due to its excellent antioxidant and anti-inflammatory effects. In this study, Cur and alginate were cross-linked by zinc ions and intermolecular hydrogen bonding to form an inhalable aqueous nanogel system to overcome Cur's low solubility and bioavailability.

Multifunctional Polysaccharide Self-Healing Wound Dressing: NIR-Responsive Carboxymethyl Chitosan / Quercetin Hydrogel.

As the misuse of antibiotics increases bacterial resistance, the treatment of infected wounds caused by bacteria encounters significant challenges. Conventional antimicrobial dressings often fall short in their ability to inhibit bacterial infections while simultaneously promoting wound healing. To address this issue, a polysaccharide self-healing hydrogel (CPP@PDA/Que3) wound dressing is successfully developed by incorporating quercetin and polydopamine nanoparticles into a carboxymethyl chitosan matrix.

Record High Uranium Photoassisted Capture Performance from Fluorine-Containing Wastewater by Ag/WO with Surface Defect and Heterostructure.

The uranium recovery from high concentration fluorine-containing uranium wastewater is a desired research target in the field of environmental radiochemistry but is very challenging due to the formation of stable uranium fluoride complexes that are quite difficult to extract. By employing surface defect engineering and interfacial heterostructure design, we present here the rational design of an efficient photocatalyst (Ag/WO) for U(VI) uptake from fluorine-containing uranium wastewater without any sacrificial agents. The defect-rich surface of Ag/WO facilitates confined adsorption of uranium, while the introduction of Ag nanoparticles enables both efficient electron-hole separation and a plasmon effect upon light irradiation.

Exploration of 1-(indolin-1-yl)-2-(thiazol-2-yl)ethan-1-one derivatives as novel anti-HBV agent with potential TLR7-agonistic effect.

Hepatitis B virus (HBV) infection, as a serious global public health issue, is closely related to the immune dysfunction. Herein, thirty-seven 1-(indolin-1-yl)-2-(thiazol-4-yl)ethan-1-one derivatives were prepared as potential immunomodulatory anti-HBV agents. Anti-HBV activity evaluation confirmed compound 11a could significantly suppress the HBV DNA replication in both wild and resistant HBV stains, with IC values of 0.

Prognostic marker CD27 and its micro-environmental in multiple myeloma.

Background: The Cluster of Differentiation 27 (CD27) is aberrantly expressed in multiple myeloma (MM) -derived. This expression facilitates the interaction between tumor and immune cells within TME via the CD27-CD70 pathway, resulting in immune evasion and subsequent tumor progression. The objective of this study is to investigate the correlation between CD27 expression and the prognosis of MM, and to elucidate its potential relationship with the immune microenvironment.

Green synthesis and multifunctional applications of nitrogen-doped carbon quantum dots via one-step hydrothermal carbonization of Curcuma zedoaria.

Low-dimensional (<10 nm) semiconductor carbon quantum dots (CQDs) have been widely used in metal ion sensing and bioimaging. Here, we used the renewable resource Curcuma zedoaria as a carbon source and prepared green carbon quantum dots with good water solubility by a hydrothermal method without any chemical reagent. At different pH values (4-6) and high NaCl concentrations, the photoluminescence of the CQDs was very stable, which indicated that they were suitable for a wide range of applications even under harsh conditions.

HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma.

Background: Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, maintaining mitochondrial metabolism and increasing drug resistance in MM. However, the mechanism of TLR4 regulation remains elusive.

Incorporation of Urinary Neutrophil Gelatinase-Associated Lipocalin and Computed Tomography Quantification to Predict Acute Kidney Injury and In-Hospital Death in COVID-19 Patients.

Background: The prevalence of acute kidney injury (AKI) in COVID-19 patients is high, with poor prognosis. Early identification of COVID-19 patients who are at risk for AKI and may develop critical illness and death is of great importance.

Objective: The aim of this study was to develop and validate a prognostic model of AKI and in-hospital death in patients with COVID-19, incorporating the new tubular injury biomarker urinary neutrophil gelatinase-associated lipocalin (u-NGAL) and artificial intelligence (AI)-based chest computed tomography (CT) analysis.