Calycosin activates Nrf2/Keap1 signaling to ameliorate hydrogen peroxide-induced spinal cord neuron death and mitochondrial dysfunction.

Oxidative stress is a hallmark of secondary injury of spinal cord injuries. Controlling oxidative stress is crucial for mitigating secondary injury and promoting functional recovery after spinal cord injuries. Calycosin is an O-methylated isoflavone with antioxidant activity.

Structural Brain Connectivity Guided Optimal Contact Selection for Deep Brain Stimulation of the Subthalamic Nucleus.

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy in ameliorating the motor symptoms of Parkinson disease. However, postoperative optimal contact selection is crucial for achieving the best outcome of deep brain stimulation of the subthalamic nucleus surgery, but the process is currently a trial-and-error and time-consuming procedure that relies heavily on surgeons' clinical experience.

Methods: In this study, we propose a structural brain connectivity guided optimal contact selection method for deep brain stimulation of the subthalamic nucleus.

Invasive cellular blue nevus in the cervical spine: A case report.

Introduction: Cellular blue nevus is an uncommon neoplasm in the spine.

Patient Concerns: Here, we present a case of a 24 years old male with a 2 months history of numbness in the right upper limb and shoulder.

Diagnosis: Cervical spine and subcutaneous tissue invasive cellular blue nevus.

Cervical spine Rosai-Dorfman disease: A case report and literature review.

Background: Rosai-Dorfman disease is a benign lymphatic tissue proliferative disease with slow growth and is rarely observed in the clinic. Most of these patients present clinically with enlarged lymph nodes. In patients with spinal extranodal Rosai-Dorfman disease, which is even rare than the disease of lymph nodes, patients may experience numbness and weakness in the extremities.

Development of an indirect ELISA for detection of the adaptive immune response of black carp (Mylopharyngodon piceus).

Black carp (Mylopharyngodon piceus) is an important fishery resource and the main breeding target in China. Due to the lack of an assay of immunoglobulin M (IgM) antibodies in black carp, there is no effective method to evaluate adaptive immune response, which limits immunological studies and vaccine development. The present study used mAbs (monoclonal antibodies) against serum IgM of grass carp as capture antibodies.

Do network synergies facilitates the realization of M&A motivation?: From the perspective of network node degree and strength change.

The current evaluation of M&A performance lacks consideration of M&A motives. In this paper, we theoretically analyse and empirically test the effect of network synergy generated by M&A on the degree of realization of corporate M&A motives and the mechanism of its effect by constructing an equity network between a listed company and its subsidiaries within the company. The results show that the greater the variation of internal network node degree and strength, the more beneficial it is to promote the degree of realization of corporate M&A motivation; the results of further mechanism of action tests show that the variation of network node degree and strength has significant effects on economies of scale, economies of scope, and transaction costs; Furthermore, the heterogeneity test finds that the effect of variation of network node degree and strength to promote the degree of realization of corporate M&A motivation is more significant in the case of non-cash payment method and related M&A.

Confined Bismuth-Organic Framework Anode for High-Energy Potassium-Ion Batteries.

Metal-organic frameworks (MOFs) with inherent porosity, controllable structures, and designable components are recognized as attractive platforms for designing advanced electrodes of high-performance potassium-ion batteries (PIBs). However, the poor electrical conductivity and low theoretical capacity of many MOFs lead to inferior electrochemical performance. Herein, for the first time, a confined bismuth-organic framework with 3D porous matrix structure (Bi-MOF) as anode for PIBs via a facile wet-chemical approach is reported.

The heat-labile toxin B subunit of E. coli fused with VP6 from GCRV (Grass carp reovirus) was expressed and folded into an active protein in rice calli.

Grass carp reovirus (GCRV) is one of the most serious pathogens threatening grass carp (Ctenopharyngon idellus) production in China. VP6 could be suitable for developing vaccine for the control of GCRV. Transgenic plants are an attractive bioreactor for their safety and ability to make economical vaccines.

Forecasting mergers and acquisitions failure based on partial-sigmoid neural network and feature selection.

Traditional forecasting methods in mergers and acquisitions (M&A) data have two limitations that significantly reduce forecasting accuracy: (1) the imbalance of data, that is, the failure cases of M&A are far fewer than the successful cases (82%/18% of our sample), and (2) both the bidder and the target of the merger have numerous descriptive features, making it difficult to choose which ones to forecast. This study proposes a neural network using partial-sigmoid (i.e.

Brain connectivity markers in advanced Parkinson's disease for predicting mild cognitive impairment.

Objectives: Mild cognitive impairment (MCI) is a well-defined non-motor manifestation and a harbinger of dementia in Parkinson's disease. This study is to investigate brain connectivity markers of MCI using diffusion tensor imaging and resting-state functional MRI, and help MCI diagnosis in PD patients.

Methods: We evaluated 131 advanced PD patients (disease duration > 5 years; 59 patients with MCI) and 48 healthy control subjects who underwent a diffusion-weighted and resting-state functional MRI scanning.

Protective Effects of Iridoid Glycoside from Corni Fructus on Type 2 Diabetes with Nonalcoholic Fatty Liver in Mice.

Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease. Accumulating evidence has demonstrated that nonalcoholic fatty liver disease (NAFLD) shares common typical features with T2DM, and they affect each other extensively. Thus, NAFLD has emerged as a novel target for T2DM prevention and care.

Correction: Nitrogen-doped carbon nanotubes as an anode for a highly robust potassium-ion hybrid capacitor.

Correction for 'Nitrogen-doped carbon nanotubes as an anode for a highly robust potassium-ion hybrid capacitor' by Xiuqi Li et al., Nanoscale Horiz., 2020, DOI: .

Nitrogen-doped carbon nanotubes as an anode for a highly robust potassium-ion hybrid capacitor.

Potassium ion hybrid capacitors (KIHCs) have drawn growing interest owing to their outstanding energy density, power density and excellent cycling stability. However, the large ionic radius of potassium triggers a huge volume change during continuous K insertion/extraction processes, restricting the development of KIHCs. Here, we report N-doped carbon nanotubes (NCNTs) for high-performance K storage.

Corni Fructus as a Natural Resource Can Treat Type 2 Diabetes by Regulating Gut Microbiota.

Accumulating evidence suggests that gut microbiota plays a crucial role in the development of metabolic diseases, especially type 2 diabetes mellitus (T2DM). The nutrient-rich resource Cornus Fructus (CF) showed curative effects on diabetes mellitus. However, the mechanism underlying its hyperglycemic activity remains obscure.

Covalent Selenium Embedded in Hierarchical Carbon Nanofibers for Ultra-High Areal Capacity Li-Se Batteries.

Lithium selenium (Li-Se) batteries have attracted increasing interest for its high theoretical volumetric capacities up to 3,253 Ah L. However, current studies are largely limited to electrodes with rather low mass loading and low areal capacity, resulting in low volumetric performance. Herein, we report a design of covalent selenium embedded in hierarchical nitrogen-doped carbon nanofibers (CSe@HNCNFs) for ultra-high areal capacity Li-Se batteries.

B subunit of cholera toxin fused with VP7 from GCRV (grass carp reovirus) was expressed in E. coli and folds into an active protein.

Grass carp reovirus (GCRV) is one of the most serious pathogens threatening grass carp (Ctenopharyngodon idella) production and results in high mortality in China. To obtain a genetically engineered oral vaccine against GCRV, the cholera toxin B subunit (CTB) of Vibrio cholerae was fused to VP7 (CTB-VP7) and transformed into BL21(DE3) for expression. SDS-PAGE and Western blotting showed that the purified rCTB-VP7 fusion protein (rCTB-VP7) was approximately 49.

Transcriptome analysis of Procambarus clarkii infected with infectious hypodermal and haematopoietic necrosis virus.

Infectious hypodermal and haematopoietic necrosis virus (IHHNV) is a major viral pathogen in cultured penaeid shrimp. IHHNV has many hosts, mainly including crustaceans. It has recently been reported that Procambarus clarkii can be infected by IHHNV.

Expression and active testing of VP7 from GCRV (Grass carp reovirus) fused with cholera toxin B subunit in rice calli.

Grass carp reovirus (GCRV) is one of the most serious pathogens threatening grass carp (Ctenopharyngodon idellus) production and results in high mortality in China. VP7 from GCRV is involved in viral infection and could be suitable for developing vaccines for the control of GCRV infection. To obtain a genetically engineered vaccine and a plant-based oral vaccine and to evaluate their immune efficacy as an oral vaccine against GCRV, cholera toxin B subunit (CTB) of Vibrio cholerae fused to VP7 (CTB-VP7) was transformed into BL21(DE3) for expression.

Mechanisms Underlying H2O2-Evoked Carbonyl Modification of Cytoskeletal Protein and Axon Injury in PC-12 Cells.

Background/aims: To investigate the mechanism that enables oxidative stress and cytoskeleton protein carbonylation to contribute to axonal dysfunction in traumatic brain injury (TBI).

Methods: We created an in vitro model of neuronal oxidative damage by exposing a neuron-like cell line (PC-12) to different concentrations (100 μM, 200 μM, and 300 μM) of H2O2 for 24 h or 48 h. Carbonyl modification of cytoskeletal proteins (β-actin and β-tubulin) and its impact on β-actin/β-tubulin filament dynamics were determined by enzyme-linked immunosorbent assay, immunostaining, and western blotting.

Apoptosis-inducing effect of myxoma virus on human neuroglioma cell lines.

The purpose of this study was to further evaluate the role of myxoma virus (MYXV) as an oncolytic agent against experimental human gliomas , and analyze the effect of MYXV on malignant glioma cells at different incubation periods and infected at different multiplicities of infection. Neuroglioma cell lines U251 and A172 were cultured with various infective doses of myxoma virus at different time points (0-3 days) and cellular survival rates were evaluated using an MTT assay. Cell viability and cell death rates were assessed using Annexin V/propidium iodide and applying flow cytometry.

Inhibition of cytoskeletal protein carbonylation may protect against oxidative damage in traumatic brain injury.

Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates protracted neuronal dysfunction and remodeling. Cytoskeletal proteins are known to be carbonylated under oxidative stress; however, the complex molecular and cellular mechanisms of cytoskeletal protein carbonylation remain poorly understood. In the present study, the expression levels of glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) were investigated in PC12 cells treated with HO.

The association of CYP1A1 genetic polymorphisms and additional gene-gene interaction with ischemic stroke in the eastern Han of China.

The aim of this study was to investigate the association between CYP1A1 gene polymorphism and ischaemic stroke (IS) risk, and the impact of gene-gene interaction on IS risk based on a Chinese Han case-control study. A total of 1162 subjects (612 men and 550 women), with a mean age of 63.1 ± 12.

Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells.

Small ubiquitin-related modifier protein (SUMO) is an evolutionarily conserved protein in a broad range of eukaryotic organisms. De-SUMOylation, the reverse reaction of SUMOylation, is regulated by a family of SUMO-specific proteases (SENPs). SENP1 is a member of the de-SUMOylation protease family involved in the de-SUMOylation of a variety of SUMOylated proteins.

β-Catenin knockdown inhibits pituitary adenoma cell proliferation and invasion via interfering with AKT and gelatinases expression.

Pituitary adenomas are among the most prevalent forms of intrinsic brain tumors. Although most pituitary adenomas are benign, some of them may become invasive and cause significant mass effect and hormonal dysfunction. We have previously shown that β-catenin is overexpressed in human pituitary adenomas and its level correlates to tumor grades.