An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks.

Mammography is the recommended imaging modality for breast cancer screening. Expressions of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), and progesterone receptor (PR) are critical to the development of therapeutic strategies for breast cancer. In this study, a deep learning model (CBAM ResNet-18) was developed to predict the expression of these three receptors on mammography without manual segmentation of masses.

CXCR7 functions in colon cancer cell survival and migration.

C-X-C chemokine receptor 7 (CXCR7) is a known promoter of tumor progression and metastasis; however, little is known about its role in colon cancer. The aim of the present study was to investigate the function of CXCR7 in human colon cancer cells. CXCR7 mRNA levels were examined in HT-29 and SW-480 human colon cancer cell lines using a quantitative polymerase chain reaction.

Quercetin reverses tamoxifen resistance in breast cancer cells.

Purpose: To investigate the effect of quercetin on the reversal of tamoxifen resistance in breast cancer cells, and explore the underlying mechanism.

Methods: We established a tamoxifen-resistant breast cancer cell line (MCF-7Ca/TAM-R), and exposed it to different concentrations of quercetin (experimental group 1: 10 μM, group 2: 25 μM, and group 3: 50μM). Each group was further subdivided into 2 subgroups: 1) simultaneous administration of quercetin and 4-hydroxytamoxifen (OHT); 2) sequential administration of quercetin (12-h induction) followed by OHT.

Inhibitory effects of water caltrop pericarps on the growth of human gastric cancer cells in vitro.

Water caltrop is a popular traditional vegetable in China, and its pericarps are always wasted. In the present work reported here, pericarps from three different Chinese water caltrop cultivars were collected and extracted using 70% methanol and hot water. All the extracts contained significant amounts of polyphenols (183.

Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90.

Purpose: To investigate the effects and the possible molecular mechanisms of metformin on HER2 positive breast cancer cells.

Methods: SK-BR-3 HER2 positive breast cancer cells were treated with different concentrations of metformin. The growth inhibitory rate of the cells was calculated by MTT assay, apoptosis was detected by flow cytometry, and the expression level of heat shock protein 90 (HSP90) was performed by Western blot analysis.