Palladium-Catalyzed Tandem Cyclization of Functional Diarylalkynes and Isocyanides for the Assembly of Isochromeno[4,3-]quinolines.

A novel strategy for the synthesis of various isochromeno[4,3-]quinolines via palladium-catalyzed tandem cyclization of functional diarylalkynes with isocyanides has been developed. This approach features excellent chemo- and regioselectivities as well as good functional group tolerance. Notably, 6-phenylimino-6-isochromeno[4,3-]quinolin-11-amines and 11-amino-6-isochromeno[4,3-]quinolin-6-ones can be selectively constructed by employing different protecting groups of functional diarylalkynes.

Divergent Synthesis of Fused Tetracyclic Heterocycles from Diarylalkynes Enabled by the Selective Insertion of Isocyanide.

Herein, we present a direct and efficient synthesis of diverse polysubstituted fused tetracyclic heterocycles with good functional group tolerance from diarylalkynes under different palladium catalytic systems. In this chemistry, an unprecedented intermolecular nucleopalladation of diarylalkynes through the highly selective sequential double insertion of isocyanide was achieved for the first time. The practicality of this method was further demonstrated by the construction of various bioactive molecules and important structural motifs, with potential applications in materials science and biochemistry.

The solvent and zinc source dual-induced synthesis of a two dimensional zeolitic imidazolate framework with a farfalle-shape and its crystal transformation to zeolitic imidazolate framework-8.

Exploring new zeolitic imidazolate frameworks (ZIFs) with specific topologies and pore structures is important for extending applications and improving performances. In this work, a new farfalle-shaped ZIF with an ordered hierarchical structure (named ZIF-F) was easily built with zinc acetate and 2-methylimidazole (MeIm) in an aqueous system at room temperature. The synthesis mechanism of ZIF-F is a dual-induction interaction of a solvent and zinc source based on the synthesis protocol of ZIF-8.