Publications by authors named "Qiunuo Li"
Article Synopsis
- The study focuses on long noncoding RNAs (lncRNAs) and their potential to encode novel proteins important for human cancers, particularly gastric cancer (GC), highlighting the uncharacterized open reading frames (ORFs) within these lncRNAs.
- Researchers identified a specific lncRNA, HCP5, which contains a non-canonical ORF that encodes a microprotein called HCP5-132aa, shown to be overexpressed in GC cells and to promote cell proliferation by inhibiting a process called ferroptosis.
- The study further demonstrates that HCP5-132aa stabilizes certain mRNAs involved in tumor growth and successfully tested the effectiveness of knocking out this
Article Synopsis
- The study identifies a small protein derived from long non-coding RNAs, called HDSP, that is linked to gastric cancer.
- HDSP promotes cancer by preventing the degradation of MECOM, which then increases the transcription of SPINK1, a gene that activates cancer-related signaling pathways.
- Targeting HDSP either by knocking it down or using it as a neoantigen enhances anti-tumor immunity and suggests it could be a new therapeutic target for treating gastric cancer.
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets.
Signal Transduct Target Ther
January 2023
Autophagy is a conserved lysosomal degradation pathway where cellular components are dynamically degraded and re-processed to maintain physical homeostasis. However, the physiological effect of autophagy appears to be multifaced. On the one hand, autophagy functions as a cytoprotective mechanism, protecting against multiple diseases, especially tumor, cardiovascular disorders, and neurodegenerative and infectious disease.
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