Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo.

Vitiligo is the most common cause of depigmentation worldwide, with immunosuppressive treatments often being inefficient and prone to recurrence, making it essential to identify new therapeutic targets. Periplakin (PPL) has been identified and confirmed as a key factor in vitiligo-related depigmentation. Based on this, a series of selective PPL agonists, specifically benzenesulfonamides, have been developed.

The Optimization of the Synthesis Process and the Identification of Levobupivacaine Hydrochloride.

In this study, we not only optimized and improved the synthesis process of levobupivacaine hydrochloride () but also conducted a comprehensive exploration of critical industrial-scale production details, and a novel high-performance liquid chromatography (HPLC) analysis method was developed. Starting with the readily available and cost-effective (,)--(2,6-dimethylphenyl)piperidine-2-carboxamide () as the initial material and utilizing l-(-)-dibenzoyl tartaric acid () for chiral separation, and then through substitution and a salting reaction, levobupivacaine hydrochloride () was obtained with high purity (chemical purity of 99.90% and enantiomeric excess () values of 99.

A squaraine-based fluorescence turn on chemosensor with ICT character for highly selective and sensitive detection of Al in aqueous media and its application in living cell imaging.

A novel and simple squaraine-based fluorescent chemosensor SQ-BH bearing the benzoylhydrazine moiety was developed for the highly sensitive and selective detection of Al in methanol-water mixture. The chemosensing behaviors of SQ-BH and its binding interaction with Al were explored by various spectroscopic analyses. The reversibility of Al recognition process was investigated using EDTA.