Unraveling the Role of RNA-Binding Proteins, with a Focus on RPS5, in the Malignant Progression of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) represents a major global health concern, demanding a thorough understanding of its molecular mechanisms for effective therapeutic strategies. RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation, with their dysregulation increasingly recognized as a hallmark of various cancers. However, the specific contributions of RBPs to HCC pathogenesis and prevention remain incompletely understood.

Occurrence, distribution, and driving factors of current-use pesticides in commonly cultivated crops and their potential risks to non-target organisms: A case study in Hainan, China.

Multiple pesticides are heavily applied in crops grown in China's tropics due to the prevalence of diseases and pests, thus posing potential risks to nontarget organisms (e.g., honeybees, lacewings, ladybugs, and humans).

Positive effect of cognitive-behavioral intervention combined with integrated health care on patients with type 2 diabetes.

Objective: This study was designed to investigate the effects of cognitive-behavioral intervention (CBI) combined with integrated health care (IHC) on glycemic control, adverse mood, health knowledge and self-efficacy in patients with type 2 diabetes mellitus.

Methods: The clinical data of 115 patients with type 2 diabetes mellitus were retrospectively collected and divided into two groups according to the intervention methods, with 57 patients in group A receiving conventional care and 58 patients in group B receiving CBI combined with IHC. The blood glucose, scores of Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), health knowledge, self-efficacy, quality of life, and nursing satisfaction were compared between the two groups before and after intervention.

Polycyclic aromatic hydrocarbons (PAHs) in surface soils of tropical reef islands in China under external plant and soil introduction: Occurrence, sources, risks, and relationships with soil properties, vegetation cover, and soil source.

This study explored the levels, sources, and risks of PAHs in soils from Yongle Atoll (YLA) and Xuande Atoll (XDA) of the Xisha Islands (XSIs) in the South China Sea, China, under different vegetation cover types and soil sources. The results clearly showed that the levels of 16 US EPA priority PAHs (ΣPAHs) are relatively low in XDA and YLA, with concentrations ranging from not detected (ND) to 151 ng/g (average 15.7 ng/g) and ND to 5.

CO Activation Using Nitrogen-Doped Carbon Nanotubes for Reductive Carbonylation of Nitroaromatics to Benzimidazolinone and Phenyl Urea.

Carbonylation of nitroaromatics with CO is extensively investigated with efficient but precious group 8-10 metal-based catalysts for the productions of both industrially and academically important chemicals such as isocyanates, formamides, carbamates, ureas and several types of heterocyclic compounds. Herein, we report that rationally designed nitrogen-doped carbon nanotubes (N-CNTs) exhibit catalytic activity toward CO activation for carbonylation of nitroaromatics to benzimidazolinones and ureas. Under the optimal conditions, N-CNT-promoted intramolecular carbonylation of 2-nitroaniline () with CO leads to formation of 1,3-dihydro-2-benzo[]imidazol-2-one in 90% yield.

Chemical Fixation of CO Using Highly Dispersed Cu on Hierarchically Porous N-Doped Carbon.

Chemical transformation of carbon dioxide (CO) into fine chemicals such as oxazolidinones and carbamates is mainly reported using transition-metal complexes as homogeneous catalysts. Herein, we demonstrate that a heterogeneous catalyst of highly dispersed Cu (Cu/NHPC) supported on hierarchically porous N-doped carbon (NHPC) can efficiently promote CO fixations to oxazolidinones and β-oxopropylcarbamates. The obtained NHPC, assembled by ultrathin nitrogen-doped carbon nanosheets with a three-dimensional (3D) structure, is readily prepared by pyrolysis of a nitrogen-containing polymer gel (NPG) in the presence of an activator of potassium bicarbonate (KHCO).

Transition-Metal-Free Synthesis of Ynones via Decarboxylative Alkynylation of α-Keto Acids under Mild Conditions.

A transition-metal-free synthetic method of various ynones via decarboxylative alkynylation of α-keto acids is described. The reaction is carried out under mild conditions and exhibits remarkable tolerance of functional groups. The mechanism of a radical process is proposed in the reaction.