Publications by authors named "Qiulu Zhong"
To investigate the impact of the effective radiation dose to immune cells (EDIC) and gross tumor volume (GTV) on lymphopenia and survival in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). Between January 2013 and December 2020, 272 LAESCC patients were treated with definitive radiotherapy in two institutions. Based on radiation doses to the lungs, heart, and body region scanned, EDIC was calculated as an equal uniform dose to the total blood considering blood flow and fraction effect.
View Article and Find Full Text PDFThis research aimed to assess the effectiveness of combining induction chemotherapy (IC) or adjuvant chemotherapy (AC) with concurrent chemoradiotherapy (CCRT) in patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC). Before propensity score matching(PSM),we retrospectively collected 457 patients with T3-4N0-1M0 NPC treated with CCRT with or without IC/AC. PSM method selected 285 patients from two cohort(148 in CCRT±IC/AC group,137 in CCRT group).
View Article and Find Full Text PDFPurpose: This study aimed to evaluate the prognosis of glioma patients with different molecular subtypes of who treated with intensity-modulated radiation therapy (IMRT).
Methods: We collected 45 glioma patients treated in our hospital between January 2017 and December 2020. All enrolled patients received postoperative IMRT and were divided into two groups based on the Isocitrate dehydrogenase (IDH status).
To investigate the impact of radiation dose on the efficacy of definitive chemoradiotherapy(dCCRT) in patients with locally advanced esophageal carcinoma. PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Wanfang, and Chinese National Knowledge Infrastructure(CNKI) were searched for eligible studies. Studies that compared high-dose radiation(HD-RT) group with low-dose radiation(LD-RT) group using modern radiotherapy techniques for locally advanced esophageal carcinoma patients in dCCRT were identified.
View Article and Find Full Text PDFIn Southeast Asia, the prevalence of nasopharyngeal carcinoma (NPC) is high; however, the molecular mechanism governing the progression of NPC is unclear. The results of the present study revealed upregulation of ring finger protein 219 (RNF219) expression in NPC tissues and cells. Overexpression of RNF219 enhanced NPC cell invasion, migration, and proliferation; whereas knockdown of RNF219 had the opposite effects.
View Article and Find Full Text PDFBackground: The study aims to explore the efficacy of adding hyperthermia to the treatment of advanced NSCLC patients based on the states of epidermal growth factor receptor (EGFR).
Patients And Methods: We included 205 advanced NSCLC patients who were received hyperthermia plus other treatment (hyperthermia group) or non- hyperthermia and other treatments (non- hyperthermia group). The OS and progression free survival (PFS) were retrospectively estimated.
Article Synopsis
- The study investigates how dose distribution affects the equivalent uniform dose (EUD) model in predicting radiation-induced brain injury in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT).
- It analyzes data from 103 patients, determining that an optimal volume-effect parameter can be found based on the max area under the curve (mAUC) from receiver operating characteristic (ROC) analyses, revealing that different volumes and dose levels influence predictive accuracy.
- The findings conclude that the volume-effect parameter in EUD varies with dose distribution, and using a critical-dose-volume EUD approach can enhance predictive capabilities compared to traditional dose/volume metrics.
Article Synopsis
- A study analyzed 221 patients with stage IA1-IIA1 cervical cancer to determine if adjuvant radiotherapy is needed after laparoscopic hysterectomy.
- Patients were divided into three groups: those receiving both surgery and radiotherapy (group A), those who had open surgery (group B), and those with laparoscopic surgery alone (group C).
- Results showed that groups A and B had significantly better 3-year local recurrence-free survival rates compared to group C, suggesting that adjuvant radiotherapy improves outcomes for early-stage cervical cancer, especially in stage IB patients.
Recent studies have shown that some inflammatory markers are associated with the prognosis of solid tumors. This study aims to evaluate the prognosis of glioma patients with or without adjuvant treatment using the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR).All patients who were diagnosed with gliomas at the first and second affiliated hospital of Guangxi Medical University between 2011 and 2020 were included in this study.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how half-brain delineation can help predict radiation damage in the temporal lobes of patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiotherapy (IMRT).
- A retrospective analysis of 220 NPC cases showed significant differences in radiation doses received by the temporal lobes compared to half-brains, with specific dosimetric parameters demonstrating varying degrees of prediction accuracy for temporal lobe injury (TLI).
- The findings suggest that using half-brain delineation simplifies the contouring process and provides reliable estimates for TLI risk, making it a practical approach for NPC patient treatment planning.
Objective: To investigate the value of CXC subfamily ligands in stage I-III patients with colorectal cancer, in order to find a new predictor for CRC patients.
Methods: We used Gene Expression Omnibus (GEO) database to collect the gene expression of CXC subfamily ligands and corresponding clinical data. The survival analysis was performed by "survival" package of Rsoftware.
The present study aimed to define high-risk patients who may benefit from additional adjuvant chemotherapy (AC) after concurrent chemotherapy in combination with intensity-modulated radiotherapy among patients with loco-regionally advanced nasopharyngeal carcinoma (NPC). A cohort of 511 NPC patients who received concomitant chemoradiotherapy (CCRT) with or without AC between January 2007 and December 2012 were retrospectively analysed. One hundred seventy-seven patients received CCRT alone, whereas 334 received CCRT + AC.
View Article and Find Full Text PDFPurpose: To evaluate the efficacy of IMRT combined with concurrent chemotherapy followed by adjuvant chemotherapy compared with IMRT combined with concurrent chemotherapy alone in patients with nasopharyngeal carcinoma.
Methods: From January 2007 to December 2014, we collected 797 staged II-IVb [UICC = Union for International Cancer Control criteria (7th edition)] NPC patients for analysis. After 1:1 matching ,we selected 261 cases as the CCRT group, another 261 patients as the CCRT+AC group.