miR-145-5p inhibits the proliferation of glioma stem cells by targeting translationally controlled tumor protein.

Glioma stem cells (GSCs) have potential for proliferation, self-renewal, and differentiation-the properties that play decisive roles in the process of malignancy in glioma. MicroRNAs (miRNAs) have been shown to regulate the characteristics of cancer stem cells. In this study, we show that miR-145-5p, a recently discovered miRNA, is expressed at low levels in primary GSCs (pGSCs).

Outcome of Primary Central Nervous System Lymphoma Treated with Combined Surgical Resection and High- Dose Methotrexate Chemotherapy: A Single-Institution Retrospective Study.

Aim: To evaluate the feasibility and long-term clinical results of combined surgical resection and high-dose methotrexate (HD-MTX) chemotherapy for primary central nervous system lymphoma (PCNSL) of the brain.

Material And Methods: Fifty-eight patients were diagnosed with PCNSL by histopathological examination of brain biopsy specimens at the Second Affiliated Hospital of Bengbu Medical College from March 2013 to December 2017. All patients received MTX at adose of 3.

MiR-424-5p Inhibits Proliferation, Invasion and Promotes Apoptosis and Predicts Good Prognosis in Glioma by Directly Targeting BFAR.

The biological function of miRNA (miR)-424-5p in glioma has not been clarified. This study was to explore the roles of miR-424-5p/Bifunctional apoptosis regulator (BFAR) axis in glioma. Ninety-six pairs of human glioma tissues and their adjacent non-cancer tissues were collected.

A metastatic skull tumor from intrahepatic cholangiocarcinoma: A case report and literature review.

Rationale: Intrahepatic cholangiocarcinoma (ICC) originates from the epithelial cells of the secondary branches that are distant from the intrahepatic bile duct. ICC is a rare pathological type of primary liver cancer, with a high malignancy rate and poor prognosis. However, patients with ICC metastasis to the skull are extremely rarely encountered.

Brain metastasis of choriocarcinoma presenting as multiple intracranial hematomas: A case report.

Rationale: Choriocarcinoma is the most malignant type of gestational trophoblastic neoplasia. Brain metastasis is the main cause of death and disability in choriocarc- inoma patients. Brain metastasis of choriocarcinoma easily invades the vessel wall to form microaneurysms, so we have reason to believe that multiple intracerebral hemorrhage is related to neoplastic intracranial microaneurysms.

Chondromyxoid fibroma of the frontal bone mimicking meningioma.

Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor that usually arises from lower-extremity long-bone metaphyses, with approximately 5.4% of all CMFs presenting in the craniofacial bones. Chondromyxoid fibroma of the frontal bone is exceedingly rare, with only a few cases reported.

Nonaneurysmal subarachnoid hemorrhage secondary to transsphenoidal surgery for pituitary adenomas.

Nonaneurysmal subarachnoid hemorrhage (SAH) is a rare and severe complication of transsphenoidal surgery for pituitary adenoma(PA). To improve recognition of this complication, we reviewed and examined 4 patients with nonaneurysmal SAH secondary to transsphenoidal surgery for PAs. Furthermore, possible causes contributed to the SAH, and the attention on preventing the occurrence of SAH is reviewed and stressed.

Safety and efficacy of frameless stereotactic brain biopsy techniques.

Objective: To explore the safety and efficacy of frameless stereotactic brain biopsy.

Methods: Diagnostic accuracy was calculated by comparing biopsy diagnosis with definitive pathology in 62 patients who underwent frameless stereotactic brain biopsy between January 2008 and December 2010 in Xiamen University Southeast Hospital. Preoperative characteristics and histological diagnosis were reviewed and then information was analysed to identify factors associated with the biopsy not yielding a diagnosis and complications.