Clinical and psychobehavioral features of outpatients with somatic symptom disorder in otorhinolaryngology clinics.

Objective: In the Otorhinolaryngology Department, patients exhibiting somatic symptoms without a medical cause are frequently neglected and left untreated. The aim of this study was to characterize the psychosomatic features of outpatients with somatic symptom disorder (SSD) to better identify patients needing treatment.

Methods: This cross-sectional study enrolled 883 consecutive patients with medically unexplained symptoms.

WDPCP Modulates Cilia Beating Through the MAPK/ERK Pathway in Chronic Rhinosinusitis With Nasal Polyps.

Cilia loss and dysfunction is one of the typical pathological features of chronic rhinosinusitis with nasal polyps (CRSwNP). Tryptophan-aspartic acid (W-D) repeat containing planar cell polarity effector (WDPCP) has been proven to be an essential element for ciliogenesis in human nasal epithelium, but its role in the beating of cilia remains unclear. In this study, we sought to investigate the role of WDPCP and its underlying mechanism behind the dysfunction in the beating of cilia in nasal polyp tissue.

Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis.

Background: One of the important pathogeneses of eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence of allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on the status of eustachian tubes in AR patients is still very limited.

Interleukin-4-induced posttranscriptional gene regulation of CCL26 by the RNA-binding protein HuR in primary human nasal polyp-derived epithelial cells.

Background: Much attention on the pathophysiology of nasal polyp (NP) has focused on eosinophils. Interleukin (IL)-4 and eotaxin-3 (C-C motif chemokine ligand 26, or CCL26) levels have been reported to be increased in eosinophilic nasal polyps. The aim of this study was to characterize CCL26 posttranscriptional regulation by the RNA-binding protein HuR in primary human nasal polyp-derived epithelial cells (hNPDECs) challenged with IL-4.

Intralesional bleomycin A5 injection for the treatment of nasal polyps through inducing apoptosis.

Conclusion: An intralesional bleomycin A5 (BLE) injection might be used as an alternative therapy for eosinophilic-type nasal polyps (NPs). BLE-induced apoptosis might play an important role in shrinkage of NPs.

Objectives: The aim of this study is to determine the effect and explore the possible role of apoptosis in shrinkage of NPs.

Allergic fungal sinusitis caused by Schizophyllum commune.

A case of allergic fungal sinusitis (AFS) due to Schizophyllum commune was reported. The pathogen was identified using molecular bioanalysis. The patient underwent the functional endoscopic sinus surgery followed by the radical maxillary sinusotomy with canine fossa trephine.

Negative suction approach to remove living leeches from the nasal cavity.

Objective: To explore a method for removing a living leech from the nasal cavity.

Materials And Methods: A total of 5 patients with nasal leech were examined. Nasal endoscopy revealed the presence of a wriggling leech in the nasal cavities of each of these patients.

Management of radiation-induced early nasal adhesion after radiotherapy for nasopharyngeal carcinoma.

Background: This study investigates the conservative management of radiation-induced early nasal adhesion after radiotherapy for nasopharyngeal carcinoma (NPC).

Methods: From June 2008 to June 2010, patients with bilateral or unilateral early nasal adhesion after radiotherapy for NPC were selected. All patients received endoscopic management and then nasal irrigation daily and nasal steroids spray for at least 3 months.

Increased expression of dectin-1 in nasal polyps.

Purpose: A fungal etiology has been proposed to underlie severe nasal polyps (NP). Dectin-1 is an innate immune pattern recognition receptor which is involved in the recognition of some pathogenic fungi. We investigated the Dectin-1 levels in NP in order to evaluate the implication of such expression with respect to the development of NP.

The diagnostic value of narrow-band imaging for the detection of nasopharyngeal carcinoma.

Objectives: To evaluate the diagnostic value of narrow-band imaging (NBI) for the detection of nasopharyngeal carcinoma (NPC).

Study Design: Prospective study.

Setting: Tertiary medical center.

[Analysis of psychoacoustic characteristics and audiology tests of tinnitus patients with sensorineural hearing loss].

Objective: Tried to find the relationship between tinnitus and each testing method, provided information for objective diagnosis and treatment for tinnitus patients with sensorineural hearing loss.

Method: The characteristics of audiology tests, including pure tone audiometric, acoustic immittance, middle ear muscle reflexes, matching test, distortion products otoacoustic emission(DPOAE) were compared in 79 ears of 69 tinnitus patients with sensorineural hearing loss.

Result: The RI positive rate was higher in Convergence curve in tinnitus patients of sensorineural hearing loss, with the rate being 51.

[Association of regulatory region of HLA-DPB1 with nasopharyngeal carcinoma in southern Chinese Hans].

Objective: To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Naso pharyngeal carcinoma in Guangdong Province Hans.

Method: The allelic types of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans.

Result: The frequencies of allelic types B/B, haplotype B were higher in patients with NPC than those of the control individuals.

[Relationship between expression of inducible nitric oxide synthase in nasal mucosa and outcome after endoscopic sinus surgery].

Objective: To explore the role of the inducible nitric oxide synthase (iNOS) in the physiological mechanism of chronic rhinosinusitis (CRS), and to elucidate the relationship between the expression of iNOS in nasal mucosa and the outcome of endoscopic sinus surgery (ESS).

Method: Thirty-one patients of CRS were divided into two groups according to the levels of IgE in blood serum: Group A with high levels of serum TIgE (TIgE > or = 90 kU/L) and Group B with low levels of serum TIgE (TIgE < 90 kU/L). Immunohistochemical procedures were taken to determine the expression of iNOS in the nasal mucosa of each CRS patient, and the CT scans of sinuses were evaluated by the Lund-Mackay CT staging system.

[The management of the stoma in endoscopic dacryocystorhinostomy].

Objective: To explore the better management of the stoma in endoscopic dacryocystorhinostomy.

Method: To review the 102 chronic dacryocystitis patients (109 eyes), who underwent the endoscopic dacryocystorhinostomy surgery with silver clips used to maintain the stoma. They were given combined therapy after the surgery, and were followed up for a period range from 3-73 months.

[Diagnosis of recurrent or residual nasopharyngeal carcinomas in the skull base area with F-18-fluoro-deoxyglucose positron emission tomography].

Objective: To investigate the diagnostic value of F-18-fluoro-deoxyglucose positron emission tomography (FDG-PET) for the recurrent or residual nasopharyngeal carcinomas in the skull base area.

Methods: Nine post-irradiation nasopharyngeal carcinoma patients did FDG-PET scanning, CT/MRI imaging and underwent nasopharynx and skull base-biopsy under endoscopy. The results of FDG-PET were evaluated and compared with CT/MRI studies and biopsies.

[The effect of the size of tonsil on uvulopalatopharyngoplasty].

Objective: To investigate how the size of tonsil affects the curative effect of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) treated with Uvulopalatopharyngoplasty (UPPP).

Method: Fifty-four cases with OSAHS treated with UPPP in our department were analyzed retrospectively. The polysomnography (PSG) was examined again one years or longer after operation.

[Value of CT scan in the early diagnosis of nasopharyngeal tumor].

Objective: To evaluate the clinical value of CT scan on the early diagnosis of nasopharyngeal masses.

Method: The results of CT scans and pathological findings to the 59 cases of localized nasopharyngeal masses were summerized.

Result: Among the 44 cases diagnosed by CT scan as nasopharyngeal carcinoma, their pathological findings revealed 35 cases of nasopharyngeal carcinoma, 2 cases of non Hodgkin's disease, 3 cases of nasopharyngeal tuberculosis, 3 cases of nasopharyngeal lymphadenosis, and 1 case of nasopharyngeal cyst.