Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.

Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.

Predictive value of urine misfolded protein in preeclampsia in twin pregnancies.

Objective: To assess the utility of urinary misfolded proteins (MP) in predicting preeclampsia (PE) in high-risk twin pregnancies.

Methods: A prospective study was conducted on 600 high-risk twin pregnancies at Shanghai First Maternity and Infant Hospital from March to August 2021. Clinical data were collected, and urinary MP levels were measured.

Changes and analysis of transvaginal forceps delivery rate in primary hospitals in the past 10 years.

Objectives: This study analyzed the changes of vaginal forceps delivery rate in Jiading Maternal and Child Health Hospital in the past 10 years in order to provide theoretical reference for reducing the rate of cesarean section and solving cephalic dystocia.

Material And Methods: The basic information, delivery means and vaginal forceps indication of 78,811 parturients who gave birth in our hospital between January 1, 2009 to December 31, 2018 were analyzed retrospectively, and statistical analysis was carried out by analysis of variance and Chi-square test.

Results: In the past 10 years, there was a significant difference in the rate of vaginal forceps use among different years (p < 0.