Publications by authors named "Qiudian Wang"
Phospholipid transfer protein (PLTP) is a widely expressed lipid transfer protein participating in the transport of cholesterol and other lipids in the plasma and peripheral tissues. Recently, elevated amyloid β (Aβ) in young and aged PLTP-deficient brains had been reported. However, the role of PLTP in amyloid precursor protein (APP) processing and Alzheimer's disease (AD) pathology remains elusive.
View Article and Find Full Text PDFAims: This study explored whether surgical stress-induced glucocorticoid receptor (GR) phosphorylation is related to postoperative cognitive dysfunction (POCD) in aged individuals. Inhibition of GR activation could be an effective treatment for POCD.
Methods: A laparotomy was given to C57/BL6 mice in POCD group both 20 and 6 months old.
Article Synopsis
- Surgical stress can lead to depression and anxiety in older adults after surgery, and oxidative stress is thought to play a role in this issue.
- Recent research on aged mice showed that dapsone, an antioxidant, significantly reduced behavioral problems and brain oxidative stress following surgery.
- The study found that dapsone effectively lowered elevated NADPH oxidase levels, suggesting it could mitigate oxidative damage caused by surgical stress in older individuals.