Publications by authors named "Qiubo Zhao"
Article Synopsis
- - Ageing is a major factor in developing osteoarthritis (OA), and this study examines how phosphoinositide-specific phospholipase Cγ (PLCγ1) influences age-related changes in cartilage and bone linked to OA.
- - Researchers used d-galactose (d-Gal) to induce chondrocyte senescence in rat and mouse models, using various lab techniques to measure cell growth and gene expression, revealing that d-Gal promotes ageing in cartilage and causes abnormalities in subchondral bone.
- - Findings indicate that decreased PLCγ1 expression in chondrocytes leads to greater senescence and accelerated ageing changes in cartilage and bone; thus, PLCγ1 could be a potential therapeutic target
Background: Although the chondroprotection of peroxisome proliferator-activated receptor α (PPARα) activation against osteoarthritis (OA) has been revealed, the regulatory mechanism of PPARα deficiency to aggravate osteoarthritic cartilage deterioration remains unclear. Here, we aimed to investigate whether and how autophagy is involved in OA pathological progression.
Methods: Model of experimental OA was established using destabilization of the medial meniscus in PPARα-KO 129S4/SvJae male mice, followed by histopathological detection of articular cartilage and immunohistochemistry detection of extracellular matrix (ECM) or autophagy-related signal molecules.
Background: To determine whether the follow-up frequency for type 2 diabetes mellitus (T2DM) patients in the National Metabolic Management Centers (MMCs) leads to different clinical outcomes.
Methods: A total of 19 908 T2DM patients with at least 6 months of facility-based follow-up were recruited in MMCs between June 2017 and April 2021 and divided into lower-frequency and higher-frequency follow-up (LFF and HFF) groups according to the median follow-up frequency of 2.0 (interquartile range 1.
Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scarce and the results are diverse. This meta-analysis was performed to determine if CCL21 gene polymorphisms correlate with the risk of developing RA.
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