Publications by authors named "Qiubai Jin"
Article Synopsis
- Abnormal lipid metabolism has been connected to issues like intervertebral disc degeneration (IVDD), sciatica, and low back pain (LBP), prompting this study to explore whether lipid-lowering drugs can help prevent these conditions.
- The research used genetic data and Mendelian randomization to investigate the impacts of specific drug targets (PCSK9, HMGCR, NPC1L1) on the development of IVDD, sciatica, and LBP, along with using data from the National Health and Nutrition Examination Survey (NHANES) to study LBP's connection to statin use.
- Results showed that not using statins was linked to a higher risk of LBP, while reductions in total cholesterol
Background: Despite growing knowledge regarding the pathogenesis of autoimmune diseases (ADs) onset, the current treatment remains unsatisfactory. This study aimed to identify innovative therapeutic targets for ADs through various analytical approaches.
Research Design And Methods: Utilizing Mendelian randomization, Bayesian co-localization, phenotype scanning, and protein-protein interaction network, we explored potential therapeutic targets for 14 ADs and externally validated our preliminary findings.
Effects of menstrual disorders and dysmenorrhea on cardiovascular disease: a Mendelian randomization study.
Front Endocrinol (Lausanne)
February 2024
Article Synopsis
- The study investigates if menstrual disorders (like excessive menstruation and irregular menses) and dysmenorrhea causally lead to an increased risk of cardiovascular disease (CVD) using data from the FinnGen study and UK Biobank.
- Results showed that genetic predispositions to excessive menstruation and irregular menses were linked to an increased risk of various heart conditions, including atrial fibrillation and myocardial infarction.
- The findings highlight a confirmed causal relationship between menstrual disorders and dysmenorrhea with cardiovascular outcomes, particularly emphasizing the connection between irregular menses and myocardial infarction.
Background: Although a growing number of observational studies suggest that angiotensin-converting enzyme inhibitors (ACEIs) intake may be a risk factor for psoriasis, evidence is still insufficient to draw definitive conclusions.
Research Design And Methods: Drug-targeted Mendelian randomization (DTMR) was used to analyze the causality between genetic proxied ACEIs and psoriasis. Furthermore, we performed a disproportionality analysis based on the FDA adverse event reporting system (FAERS) database to identify more suspicious subclasses of ACEIs.
Article Synopsis
- The study investigates the causal links between gut microbiota (GM) and chronic kidney disease (CKD), highlighting the potential role of chronic systemic inflammation in CKD, but acknowledges that these relationships are not fully understood.
- Using advanced statistical methods, researchers analyzed extensive genome-wide association study (GWAS) data to assess the influence of various GM on CKD risk factors such as estimated glomerular filtration rate (eGFR) and C-reactive protein (CRP).
- Findings indicate that certain types of gut bacteria can either protect against or increase the risk of CKD, with specific GM correlating with kidney function and inflammation markers, while no significant biases or inconsistencies in the results were
Background: The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations and challenges in the early diagnosis and targeted treatment of cancers. Accordingly, there is an urgent need to identify novel targets and develop new targeted drugs.
View Article and Find Full Text PDFCausal effects between gut microbiota and IgA nephropathy: a bidirectional Mendelian randomization study.
Front Cell Infect Microbiol
May 2023
Article Synopsis
- Therapeutic strategies targeting gut microbiota (GM) may help in treating IgA nephropathy (IgAN), but studies have only shown a correlation, not causation, between them.
- A bi-directional Mendelian randomization analysis was conducted using data from GM and IgAN genome-wide association studies (GWAS) to explore this causal relationship.
- The study identified Genus Enterorhabdus as a protective factor against IgAN and Genus Butyricicoccus as a risk factor, suggesting these bacteria could serve as potential biomarkers for new therapies and enhance our understanding of the gut-kidney connection.
Sphingosine-1-phosphate (S1P) is a sphingolipid mediator that exerts a variety of biological functions, including immune, cardiovascular, and neurological regulation as well as tumor promotion, through high-affinity G protein-coupled receptors (S1P). It has been reported that circulating S1P levels remain higher in patients with psoriasis than in healthy individuals and that circulating S1P levels do not decrease after anti-TNF-α treatment in those patients. The S1P-S1PR signaling system plays an important role in inhibiting keratinocyte proliferation, regulating lymphocyte migration, and promoting angiogenesis, thus contributing to the regulation of psoriasis pathogenesis.
View Article and Find Full Text PDFBackground: Growing evidence shows a significant association between intestinal flora and allergic diseases, specifically atopic dermatitis (AD), allergic rhinitis (AR), and allergic asthma (AA). However, the causality has not yet been clarified.
Objective: We conducted a bidirectional two-sample Mendelian randomization (TSMR) analysis to study the causal relationships between intestinal flora classification and AD, AR, or AA.
Article Synopsis
- The WHO declared COVID-19 a pandemic on March 11th, prompting many clinical trials globally, with this study aimed at reviewing their characteristics to reduce redundancy.
- A total of 393 studies were analyzed, predominantly from mainland China, focusing mainly on therapeutic effects, with random controlled trials making up over half of the research.
- Issues like improper outcome setting and recruitment delays suggest that many studies may not reach completion, highlighting the need for better strategies and data sharing during health emergencies.