Publications by authors named "QiuYan Chen"

Background: Despite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their correlations with age at diagnosis and time since diagnosis among NPC survivors.

Methods: A total of 1872 NPC patients were surveyed from September 2020 to June 2021 in this cross-sectional survey.

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Background: The microbiota plays a significant role in the tumor microenvironment, and its impact on tumor development and treatment outcome cannot be overlooked. Thus, it is essential to comprehend the interactions between the microbiota and the tumor microenvironment.

Recent Findings: With the advent of next-generation sequencing, microbiota research has advanced significantly in recent years.

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The objective of this research was to investigate how dietary antimicrobial peptides (AMP), namely, Isalo scorpion cytotoxic peptide (IsCT), affect the gill physical barrier function and immune function of grass carp challenged with (). Five hundred forty grass carp were randomly allocated to six groups and fed to varying levels of IsCT in the diet (0, 0.6, 1.

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  • The study assessed the feasibility and safety of performing total laparoscopic hysterectomy (TLH) without using a uterine manipulator in 72 patients with early-stage cervical cancer from January 2018 to December 2020.
  • Results showed that both groups experienced a significant decrease in tumor marker levels after surgery, with the group that did not use the uterine manipulator showing even lower levels postoperatively.
  • Over a three-year follow-up, there were no notable differences in postoperative complications or survival rates between the two groups, indicating that the uterine manipulator is not necessary for safe and effective TLH in such patients.
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  • The study investigates the effects of the PD-1 inhibitor toripalimab combined with chemoradiotherapy on patients with advanced nasopharyngeal carcinoma, particularly those with high EBV DNA levels, to see if it reduces recurrence risk compared to placebo.* -
  • Conducted at Sun Yat-sen University Cancer Centre in China, 150 eligible patients were randomly assigned to receive either toripalimab or a placebo before and after chemoradiotherapy, focusing on the 2-year progression-free survival rate as the main outcome measure.* -
  • Initial findings suggest that most of the participants were male (77%), and by the latest follow-up, the median progression-free survival period was approximately 37.8 months,
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Background: Chronic kidney inflammation and podocyte injury are key pathological features of Diabetic Nephropathy (DN). Puerarin has been shown to inhibit podocyte pyroptosis and provide renal protection, although its molecular mechanism remains unclear.

Methods: The effects and mechanisms of puerarin on podocyte pyroptosis were investigated in a DN mouse model.

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Although many researches have been reported about the high performance of polymeric carbon nitride (PCN) photoanode, but it is still limited by poor stability. In this work, PCN nanosheets photoanode is used as a platform to investigate the sources of this issue. Through a combination of photoelectrochemical, X-ray Photoelectron Spectroscopy (XPS), and Potentiostatic Electrochemical Impedance Spectroscopy (PIES) measurements, it is shown that amounts of C═O bonds will form on the surface of PCN photoanodes, which limited the separation of the photogenerated carriers.

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  • The study aimed to compare the long-term quality of life (QoL) between survivors of nasopharyngeal carcinoma (NPC) who were children versus adults, and to identify clinical factors influencing QoL.
  • A total of 420 NPC survivors (195 paediatric and 225 adult) participated, all having survived at least 8 years post-treatment with intensity-modulated radiotherapy (IMRT).
  • Results indicated that paediatric survivors reported better QoL scores across several areas, such as global health, physical function, and social function, but had lower cognitive function compared to adults; different clinical factors were linked to QoL in each group.*
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Background: Intratumor heterogeneity is common in cancers, with different cell subtypes supporting each other to become more malignant. Nasopharyngeal carcinoma (NPC), a highly metastatic cancer, shows significant heterogeneity among its cells. This study investigates how NPC cell subtypes with varying metastatic potentials influence each other through exosome-transmitted molecules.

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Background: To investigate the prognosis of longitudinal health-related quality of life (HRQOL) during concurrent chemoradiotherapy (CCRT) on survival outcomes in patients with advanced nasopharyngeal carcinoma (NPC).

Methods: During 2012-2014, 145 adult NPC patients with stage II-IVb NPC were investigated weekly using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORCT QLQ-C30) during their CCRT period. The effects of longitudinal trends of HRQOL on survival outcomes were estimated using joint modeling, and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were reported as a 10-point increase in HRQOL scores.

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Background: Ethnic socialisation plays a vital role in the development of ethnic minority adolescents. However, the generalizability of research findings beyond the context of immigrant societies in the United States remains unclear.

Methods: Utilising a person-centred approach, this study analysed a sample of 2,600 ethnic minority adolescents in China (55.

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Objectives: This study aimed to evaluate the efficacy of adjuvant chemotherapy (AC) in patients with different midpoint-radiotherapy (mid-RT) Epstein-Barr virus (EBV) DNA plasma loads for locoregionally advanced nasopharyngeal carcinoma (NPC), and to provide decision-making regarding the use of AC.

Materials And Methods: A total of 675 consecutive patients diagnosed with stage III-IVa NPC were enrolled in this study. All patients underwent concurrent chemoradiotherapy (CCRT), either with or without induction chemotherapy or AC, or a combination of both.

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Developing T1-weighted magnetic resonance imaging (MRI) contrast agents with enhanced biocompatibility and targeting capabilities is crucial owing to concerns over current agents' potential toxicity and suboptimal performance. Drawing inspiration from "biomimetic camouflage," we isolated cell membranes (CMs) from human glioblastoma (T98G) cell lines via the extrusion method to facilitate homotypic glioma targeting. At an 8:1 mass ratio of ferric chloride hexahydrate to gallic acid (GA), the resulting iron (Fe)-GA nanoparticles (NPs) proved effective as a T1-weighted MRI contrast agent.

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Objective: This study aimed to identify the factors associated with insomnia in MRI-negative epilepsy and uncover the underlying pathological mechanism driving insomnia within the context of epilepsy.

Methods: We conducted a retrospective study of patients with MRI-negative epilepsy recruited consecutively from December 2021 to December 2022. All subjects completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS).

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Article Synopsis
  • - Stroke is a leading cause of death and disability globally, with ischemic stroke becoming more common and creating a major burden for patients and society.
  • - The review focuses on new technologies in managing ischemic stroke, such as neuroimaging, regenerative medicine, and nanomedicine, while discussing their advantages, uses, and challenges.
  • - The authors propose strategies for advancing technology aimed at preventing, diagnosing, and treating ischemic stroke effectively.
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Mycoplasma synoviae (MS) is a contagious pathogen that poses a significant threat to the poultry industry. Detection plays an important role in the prevention and control of MS, particularly in differentiating between wild-type MS and live attenuated vaccine strains for vaccination selection and culling of animals with wild-type only. The live attenuated ts+ vaccine strain MS-H is recognized as the most effective and widely used vaccine.

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The hydrogen (H) evolution rates of photocatalysts suffer from weak oxidation and reduction ability and low photogenerated charge carrier separation efficiency. Herein, by combining band-gap structure optimization and vacancy modulation through a one-step hydrothermal method, InO containing oxygen vacancy (O/InO) is simply introduced into InS to promote photocatalytic hydrogen evolution. Specifically, the change in the sulfur source ratio can induce the coexistence of O/InO and InS in a high-temperature hydrothermal process.

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Background: Cardiomyocyte apoptosis plays a vital role in myocardial ischemia-reperfusion (MI/R) injury; however, the role of beclin1 (BECN1) remains unclear. This study aimed at revealing the function of BECN1 during cardiomyocyte apoptosis after MI/R injury.

Methods: In vivo, TTC and Evan's blue double staining was applied to verify the gross morphological alteration in both wild type (WT) mice and BECN1 transgene mice (BECN1-TG), and TUNEL staining and western blot were adopted to evaluate the cardiomyocyte apoptosis.

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Article Synopsis
  • Traditional clinical indicators have limited effectiveness in predicting survival for patients with locally recurrent nasopharyngeal carcinoma due to tumor variance.
  • A machine learning-based radiomic signature, developed from MRI features, was validated in a large study and showed strong prognostic ability for overall survival.
  • This radiomic signature not only improved patient risk classification but also highlighted differences in immune response, suggesting potential for personalized treatment approaches.
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The relationship between the composite dietary antioxidant index (CDAI), a comprehensive measure of individual dietary antioxidants, and the prevalence and mortality of metabolic syndrome (MetS) remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We explored these relationships using two independent cohorts.

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Background: Ischemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements.

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Objective: This study was designed to assess the efficacy and safety of cadonilimab monotherapy, a first-in-class, bi-specific PD-1/CTLA-4 antibody, in patients with previously treated recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC).

Patients And Methods: This multicenter, open-label, single-arm, phase II clinical trial enrolled patients with R/M-NPC who had failed first-line platinum-based chemotherapy and second-line single agent or combined chemotherapy, and immunotherapy-naive. Patients received cadonilimab for 6 mg/kg once every 2 weeks (Q2W).

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Background And Purpose: Diabetic nephropathy (DN) is an important cause of end-stage renal disease, with podocyte injury as the main feature. Pyroptosis plays a non-negligible role in the process of diabetic nephropathy. Puerarin (PR) treatment of diabetic nephropathy has great potential, but the mechanism is not very clear.

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Background And Purpose: Nab-paclitaxel is a promising albumin-bound paclitaxel with a therapeutic index superior to that of docetaxel, but the optimal dose of nab-paclitaxel combined with cisplatin and capecitabine as induction chemotherapy followed by concurrent chemoradiotherapy for patients with locally advanced nasopharyngeal carcinoma remains unknown.

Materials And Methods: This was an open-label, single-arm study investigating the safety and efficacy of nab-paclitaxel + cisplatin + capecitabin as IC for three cycles, followed by cisplatin CCRT, conducted by using the standard "3 + 3" design in LA-NPC. If more than one-third of the patients in a cohort experienced dose-limiting toxicity (DLT), the dose used in the previous cohort was designated the maximum tolerated dose (MTD).

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Purpose: The purpose of this study was to identify the factors associated with insomnia in patients with epilepsy (PWE) and provide evidence for clinical prevention and treatment.

Methods: PWE who visited our epilepsy clinic from December 2021 to December 2022 were enrolled in our study. All participants completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS).

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