[Mediator Complex Subunit 8:Expression in Gastric Cancer, Prognostic Significance,and Impact on Cell Cycle].

Objective To investigate the expression and prognostic significance of mediator complex subunit 8 (MED8) in gastric cancer and its impact on the cell cycle.Methods The expression of MED8 in gastric cancer and adjacent tissues and its correlation with patients' prognosis were analyzed using public databases.A validation cohort of 104 patients who underwent radical resection for gastric cancer in the First Affiliated Hospital of Bengbu Medical College from June 2012 to July 2017 was included.

Comparison of laparoscopic selective colectomy based on barium-strip examination and subtotal colectomy for adult slow-transit constipation.

Background: Surgical management of adult slow-transit constipation (ASTC) can be effective for patients with intractable symptoms. This study aimed to evaluate whether barium-strip examination and selective colectomy improved post-operative outcomes in ASTC patients in comparison with subtotal colectomy.

Methods: A retrospective cohort study of 53 cases with refractory ASTC was conducted between June 2008 and June 2014.

Synthesis and in vitro antitumor activity of 1,3,4-oxadiazole derivatives based on benzisoselenazolone.

A series of novel 1,3,4-oxadiazole derivatives based on benzisoselenazolone has been prepared and tested for antiproliferative activity in vitro against the cells of human cancer cell lines: SSMC-7721 (human liver cancer cell), MCF-7 (human breast cancer cell) and A549 (human lung cancer cell). All the compounds obtained exhibited antiproliferative activity and showed selective cytotoxicity against different cancer cells. Compounds 7d and 7i showed significant antiproliferative activities against MCF-7 cells, with IC50 values of 1.

catena-Poly[[[diaqua-copper(II)]-{μ-4,4'-[1,4-phenyl-enebis(methyl-eneimino)]dibenzoato}] monohydrate].

The asymmetric unit of the title polymeric compound, {[Cu(C(22)H(18)N(2)O(4))(H(2)O)(2)]·H(2)O}(n), contains a Cu ion situated on an inversion center, half of a centrosymmetric 4,4'-[1,4-phenyl-enebis(methyl-eneimino)]dibenzoate ligand, a coordin-ated water mol-ecule in a general position and an uncoordin-ated water mol-ecule situated on a twofold rotation axis. The distorted octa-hedral coordination geometry of the Cu(II) ion is formed by six O atoms. The -NH- groups of the ligand are involved in intra-molecular N-H⋯O hydrogen bonds, while the water mol-ecules participate in the formation of a three-dimensional supra-molecular framework via inter-molecular O-H⋯O hydrogen bonds.

Laparoscopic Heller-Dor operation for patients with achalasia.

Background: Laparoscopic Heller cardiomyotomy and Dor fundoplication is the surgical procedure of choice for esophageal achalasia. The aim of this study was to investigate the clinical outcome of laparoscopic Heller-Dor procedure in our initial series of 25 patients with achalasia.

Methods: Between October 2003 and January 2006, a total of 25 patients with achalasia underwent laparoscopic Heller-Dor operation.