Inducible nitric oxide synthase is involved in the oxidation stress induced by HIV-1 gp120 in human retina pigment epithelial cells.

Background: The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120 has been implicated in the development of AIDS-associated retinopathy. The present study tested the hypothesis that gp120 may induce oxidative stress including up regulation of inducible nitric oxide synthase (iNOS) and production of malondialdehyde (MDA) and nitric oxide (NO) to mediate retinopathy in retinal pigment epithelial (RPE) cells.

Methods: Human RPE cell line D407 was cultured and treated with gp120.

[Changes in monochromatic higher-order aberrations in different pupil sizes with accommodation in young emmetropes].

Objective: To study the effect of accommodation on monochromatic higher-order aberrations in different pupil sizes in the young emmetropes.

Methods: Intervention trial design was used in the study. The monochromatic aberrations were measured in 12 eyes from 12 undulated young emmetropes in 4.