Publications by authors named "Qiu-rong Ruan"
Article Synopsis
- The study aimed to assess the effectiveness of F-FDG PET/CT scans in distinguishing lymphoma from other causes in patients experiencing fever of unknown origin (FUO) with swollen lymph nodes.
- Researchers conducted a prospective study involving 163 patients, analyzing PET/CT results alongside other diagnostic methods like lymph-node biopsies to compare lymphoma and benign cases.
- Findings indicated that while PET/CT had moderate sensitivity (81%) and low specificity (48%) for diagnosing lymphoma, a scoring model based on PET/CT readings and clinical factors showed high accuracy, suggesting it could serve as a reliable noninvasive diagnostic tool.
Article Synopsis
- This study investigates how F-FDG PET/CT imaging can help distinguish between different causes of fever of unknown origin (FUO) by analyzing the metabolic characteristics and clinical parameters of patients.
- A total of 524 patients were studied, with diagnostic models developed using the data from 369 patients and validated with another 155.
- The study found that combining PET/CT imaging with specific clinical factors significantly improves the ability to identify infections, malignancies, and inflammatory diseases, showing high accuracy in both testing and validation groups.
Article Synopsis
- The study investigates the occurrence of infection-associated hemophagocytic syndrome (IAHS) in critically ill COVID-19 patients, analyzing data from 268 patients between February 2020 and February 2020.
- It finds that 17 patients (6.3%) met the criteria for secondary hemophagocytic lymphohistiocytosis (sHLH), all of whom unfortunately died soon after diagnosis.
- The research highlights the high mortality rate associated with sHLH in COVID-19 patients, suggesting that SARS-CoV-2 may trigger this severe condition and emphasizing the importance of early detection for better patient outcomes.
Article Synopsis
- * A diagnostic tool was developed through analysis of FUO patients in three Chinese hospitals, using logistic regression to create a scoring system based on clinical and lab evaluations.
- * This tool showed promising results with an AUC of 0.83 for distinguishing causes of FUO, indicating it can reliably help predict whether the fever is due to infection or another reason.
Filamin A and 14-3-3-σ are closely associated with the development of breast cancer. However, the exact relationship between them is still unknown. The present study aimed to examine the interaction of filamin A with 14-3-3-σ in the invasion and migration of breast cancer.
View Article and Find Full Text PDFCorrelation of Forkhead Box c2 with subtypes and invasive ability of invasive breast cancer.
J Huazhong Univ Sci Technolog Med Sci
December 2014
Article Synopsis
- FOXC2 is a member of the forkhead transcription factor family and its role in invasive breast cancers, particularly basal-like breast cancer (BLBC), is still not fully understood.
- In a study analyzing 103 invasive breast cancer cases and 15 normal breast samples, it was found that FOXC2 was mostly weakly expressed in invasive cancers but strongly expressed in 60.7% of BLBCs, indicating a potential link to cancer aggression.
- The research concluded that FOXC2 expression correlates with several clinical factors and suggests that FOXC2 may serve as a valuable marker for diagnosing and predicting the prognosis of invasive breast cancer subtypes.
[Clinicopathologic features of phyllodes tumors and their research progress].
Zhonghua Bing Li Xue Za Zhi
November 2013
Objective: Construction of a small interfering RNA (siRNA) eukaryotic expression vector specific to mouse myocardin gene and study on the role of myocardin-siRNA on differentiation of mouse bone mesenchymal stem cells (MSCs) into smooth muscle-like cells induced by PDGF-BB in vitro.
Methods: Mouse MSCs were isolated from bone marrow and cultured with 50 mg/L PDGF-BB and fetal bovine serum (20%). Specific myocardin-siRNA sequence was cloned into a plasmid pGenesil-1.
[Expression of myocardin in differentiation of bone marrow-derived mesenchymal stem cells to smooth muscle cells].
Zhonghua Bing Li Xue Za Zhi
October 2008
Objective: To investigate the expression profiles of myocardin gene during the differentiation of bone marrow-derived mesenchymal stem cell to smooth muscle cells in the conditional medium combined with a high concentration of fetal bovine serum (FBS).
Methods: Marrow-derived mesenchymal stem cells were isolated and purified from mouse femoral bone and shinbones using differential adherent methods. Cells at the third passage were induced by 20% FBS in conditioned medium, conditioned medium alone, 20% FBS or 10% FBS alone respectively.
Dehydroepiandrosterone anti-atherogenesis effect is not via its conversion to estrogen.
Acta Pharmacol Sin
January 2009
Aim: This study was conducted to demonstrate the anti-atherosclerotic effect of dehydroepiandrosterone (DHEA) and to investigate its possible mechanisms and whether this effect is related to its conversion to estrogen.
Methods: Forty male New Zealand White rabbits aged 3 months were divided into 5 groups (n=8 per group) and fed different diets for 10 weeks. Serum lipid levels, the area of atherosclerotic lesions and the mRNA levels of monocyte chemoattractant protein-1 (MCP-1) and vascular cell adhesion molecule-1 (VCAM-1) in aortic lesions were measured.
[Filtrating smooth muscle progenitor cells from mouse bone marrow mesenchymal stem cells by recombinant Psm22alpha-EGFP-1].
Zhonghua Bing Li Xue Za Zhi
December 2007
Objective: To identify and select smooth muscle progenitor cells from mouse bone marrow mesenchyme stem cell population and to characterize smooth muscle progenitor cells in peripheral blood.
Methods: Recombinant expression vector with the promoter of sm22alpha was constructed to have an enhancement type green fluorescent protein expression plasmid (EGFP-1). The construct was transfected into mouse bone marrow mesenchyme stem cells using Lipofectamine 2000.
Tetramethylpyrazine (TMP), an effective component of traditional Chinese medicine Chuanxiong, is commonly used to resolve embolism. Its possible therapeutic effect against atherosclerosis has received considerable attention recently. Angiotensin II (Ang II) is highly implicated in the proliferation of vascular smooth muscle cells (VSMCs), resulting in atherosclerosis.
View Article and Find Full Text PDF[The influence of Survivin in drug resistance of breast cancer cell].
Zhonghua Bing Li Xue Za Zhi
June 2005
Article Synopsis
- The study investigates how anisodamine might help treat infectious shock by looking at its effects on certain proteins (tissue factor and PAI-1) in human vascular endothelial cells when exposed to lipopolysaccharide (LPS).
- Researchers cultured human umbilical vein endothelial cells and used various assays to measure protein levels, mRNA expression, and the involvement of the NF-kappa B pathway in the response to LPS and anisodamine.
- The findings suggest that anisodamine can significantly reduce LPS-induced increases in tissue factor and PAI-1, potentially through blocking the activation of the NF-kappa B pathway.