[Regulatory Mechanism of Mangiferin Combined with Bortezomib on Malignant Biological Behavior of Burkitt Lymphoma and Its Effect on Expression of CXC Chemokine Receptors].

Objective: To analyze the effects of mangiferin combined with bortezomib on the proliferation, invasion, apoptosis and autophagy of human Burkitt lymphoma Raji cells, as well as the expression of CXC chemokine receptors (CXCRs) family, and explore the molecular mechanism between them to provide scientific basis for basic research and clinical work of Burkitt lymphoma.

Methods: Raji cells were intervened with different concentrations of mangiferin and bortezomib alone or in combination, then cell proliferation was detected by CCK-8 assay, cell invasion ability was detected by Transwell chamber method, cell apoptosis was detected by Annexin V/PI double-staining flow cytometry, apoptosis, autophagy and Akt/mTOR pathway protein expression were detected by Western blot, and the expression changes of CXCR family was detected by real-time quantitative PCR (RT-qPCR).

Results: Different concentrations of mangiferin intervened Raji cells for different time could inhibit cell viability in a concentration- and time-dependent manner ( =-0.

[Development of a new FTIR car-borne oil content analyzer].

Turlun structure was introduced into the Fourier transform interference system in the present paper in order to decrease the size and cost of the whole system and to increase the ability of vibration resistance to meet the requirement of car-borne outdoor monitoring application. The speed deviation of the voice coil motor (VCM) driving system, which is based on feedback of interference wavelength of reference laser and DSP control, is within 5%. The standard oil sample was used to test the performance of the spectrometer.