Publications by authors named "Qiu-Zheng Du"
Article Synopsis
- The study aimed to investigate metabolic biomarkers in erosive and reticulated oral lichen planus (OLP) using non-targeted metabolomics, correlating these metabolites with gene expression to understand the metabolic pathways involved in OLP.
- Involving 153 participants, researchers identified 19 differential metabolites in erosive OLP and 25 in reticulated OLP, along with 14 shared metabolites between both forms, and constructed diagnostic models based on these findings.
- The analysis revealed 756 differentially expressed genes, with 19 genes linked to 12 metabolites, suggesting metabolic changes related to alanine, aspartate, and glutamate metabolism play a significant role in the pathogenesis of OLP
Article Synopsis
- Oral lichen planus (OLP) is a chronic inflammatory condition linked to cancer risk, and current diagnostic methods are limited, prompting the need for new approaches like metabolomics.
- A study used Ultra-Performance Liquid Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry (UHPLC-Q-Orbitrap HRMS) to analyze serum metabolites from 115 OLP patients and 124 healthy controls, identifying 23 differential metabolites.
- Three key metabolites showed strong potential as biomarkers, achieving a diagnostic accuracy of 86.1%, paving the way for improved early detection and understanding of OLP and its precancerous nature.
The drug combination of biapenem (BIPM) and xuebijing injection (XBJ) is commonly applied for the treatment of sepsis in China. However, the potential synergistic mechanism is still enigmatic. There have been no studies focused on the plasma metabolome alterations in sepsis after the intervention of this combination.
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