Prediction Model for Early Subacute Phase Tracheostomy Decannulation in Patients with Stroke.

This study aims to identify the factors influencing decannulation in patients with stroke who underwent tracheostomy during the early subacute phase. A retrospective analysis was conducted on 219 patients with stroke who underwent a tracheostomy at a tertiary hospital between January 2020 and December 2023. Among them, there were 155 males and 64 females.

Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats.

This study aimed to elucidate the neurotherapeutic effect of hyperbaric oxygen (HBO) on brain injury and the potential role of dynamin-related protein 1 (Drp1) and its regulatory pathway in heatstroke (HS) rats. In in vivo experiments, rats were exposed to HBO after the onset of HS, or the same pressure but normal air as a control. The results indicated that HBO decreased the mortality and thermoregulatory dysfunction and prolonged the survival time of HS rats.

[Study of copper metabolism and liver damage in TX Mice-an animal model for liver disease].

Objective: To provide right time points in selection of right aged animals and the normal physiological data of TX mice.

Methods: 7-12 months old TX and DL mice were studied, each group contained 3 female and 3 male mice of TX or DL mice. The concentration of copper in the serum, dry tissues (liver, brain and kidney), together with copper biochemistry indexes were measured.

[Clinical manifestations and molecular genetics of spinal bulbar muscular atrophy: report of 5 cases].

Objective: To study the clinical and molecular genetic characteristics of spinal bulbar muscular atrophy (SBMA).

Methods: The clinical data, including case history, physical examination, biochemical analyses of blood, EMG, and muscle biopsy, of 5 Chinese patients with SBMA, all males, aged 29 - 58, with the onset age of 36 (17 - 49), were collected the information of in 5 cases. Four patients underwent PCR to examine the number of copies of CAG repeat region in androgen receptor (AR) gene.

[Molecular genetics and its clinical application in the diagnosis of spinocerebellar ataxias].

Objective: To study the strategy of applying molecular genetic methods and techniques in the diagnosis of spinocerebellar ataxias (SCA).

Methods: This study included 43 patients with SCA from 36 families, 38 sporadic SCA patients, 60 healthy individuals from the SCA families and 44 normal controls. The trinucleotide repeats were detected by polymerase chain reaction (PCR), denaturing polyacrylamide gel electrophoresis and silver staining technique.

[Molecular genetic diagnosis and clinical analysis of spinocerebellar ataxia type 7].

Objective: To study the molecular genetic diagnosis and clinical characteristics of spinocerebellar ataxia type 7 (SCA7).

Methods: This study included 43 patients with autosomal dominant SCA from 36 families, 38 sporadic SCA patients, 60 healthy individuals from the SCA families and 44 normal controls without family SCA history. The SCA7 (CAG)n mutations were detected by PCR, denaturing polyacrylamide gel electrophoresis and silver staining technique.

[A study on the relation between the location of brain damage and agraphia of Chinese].

Objective: To investigate the relation between the location of brain damage and Chinese agraphia.

Methods: Aphasia Battery of Chinese (ABC) and Chinese Agraphia Battery (CAB) were used to examine the ability of oral language and writing. Different types of aphasia and agraphia were detected.