A New Immunosuppressive Therapy for Very Severe Aplastic Anemia in Children with Autoantibodies.

Objective: At present, a number of very severe aplastic anemia (VSAA) patients cannot receive hematopoietic stem cell transplantation (HSCT) or standard immunosuppressive therapy (IST) due to the high cost of therapy, shortage of sibling donors, and lack of resources to support the HSCT. In addition, some VSAA patients with autoantibodies have no life-threatening infections or bleeding at the time of initial diagnosis. Considering the disease condition, economics and other factors, the present study designed a new and relatively mild treatment strategy: cyclosporine A plus pulsed high-dose prednisone (CsA+HDP).

PM promotes Drp1-mediated mitophagy to induce hepatic stellate cell activation and hepatic fibrosis via regulating miR-411.

Background: Particulate matter≤ 2.5 μm (PM) is a type of environmental agent associated with air pollution, which induces hepatic fibrosis. However, the function and mechanism of PM on hepatic stellate cell (HSC) proliferation and fibrosis remain largely unknown.

[Pure red cell aplasia in children: a clinical analysis of 16 cases].

Objective: To study the clinical features, treatment, and prognosis of pure red cell aplasia (PRCA) in children.

Methods: A retrospective analysis was performed for the clinical data of 16 children with PRCA. The outcome and prognosis of patients treated with prednisone combined with Huaiqihuang granules versus prednisone alone were evaluated.

PM2.5 induces liver fibrosis via triggering ROS-mediated mitophagy.

Background: The increasing epidemic of fine particulate matter (PM2.5) is a serious threat to human health. It induces the occurrence of liver fibrosis, but its molecular mechanism is not yet clear.

Trisomy 21 with t(5; 11) chromosomal translocation as new unfavorable cytogenetic abnormalities in pediatric acute myeloid leukemia type M2: One case report of nine-year follow-up and literature review.

We report one case of pediatric acute myeloid leukemia type 2 (AML-M2) who presented with karyotypic aberration of trisomy 21 with the t(5;11) chromosomal translocation. The patient achieved complete remission after two cycles of chemotherapy of daunorubicin, cytarabine and etoposide. Then, follow-up cytogenetic analysis from bone marrow cell cultures demonstrated a normal karyotype of 46, XY.

A retrospective analysis of 56 children with hemophagocytic lymphohistiocytosis.

Aim: The aim of this study was to investigate the etiological factors, clinical features, and prognostic factors in children with hemophagocytic lymphohistiocytosis (HLH).

Methods: Fifty-six children with HLH in Wuhan Union Hospital, People's Republic of China, were retrospectively analyzed in recent years. We reviewed the medical records of 56 HLH children hospitalized from 2000 to 2013 to identify the possible prognostic factors.

Graphene-deposited microfiber photonic device for ultrahigh-repetition rate pulse generation in a fiber laser.

We report on the generation of a high-repetition-rate pulse in a fiber laser using a graphene-deposited microfiber photonic device (GMPD) and a Fabry-Perot filter. Taking advantage of the unique nonlinear optical properties of the GMPD, dissipative four-wave mixing effect (DFWM) could be induced at low pump power. Based on DFWM mode-locking mechanism, the fiber laser delivers a 100 GHz repetition rate pulse train.

Noise-like pulse trapping in a figure-eight fiber laser.

We report on the trapping of noise-like pulse in a figure-eight fiber laser mode locked by nonlinear amplifier loop mirror (NALM). After achievement of noise-like vector pulse, it was found that the wavelength shift of the two resolved polarization components responsible for the pulse trapping was very sensitive to the cavity birefringence. By properly rotating the polarization controllers (PCs), the wavelength shift could be up to 4.

Dual-wavelength rectangular pulse Yb-doped fiber laser using a microfiber-based graphene saturable absorber.

We reported on the generation of dual-wavelength rectangular pulses in a Yb-doped fiber laser (YDFL) by using a microfiber-based graphene saturable absorber (GSA). The duration of dual-wavelength rectangular pulse could be varied from 1.41 ns to 4.

Vector nature of multi-soliton patterns in a passively mode-locked figure-eight fiber laser.

The vector nature of multi-soliton dynamic patterns was investigated in a passively mode-locked figure-eight fiber laser based on the nonlinear amplifying loop mirror (NALM). By properly adjusting the cavity parameters such as the pump power level and intra-cavity polarization controllers (PCs), in addition to the fundamental vector soliton, various vector multi-soliton regimes were observed, such as the random static distribution of vector multiple solitons, vector soliton cluster, vector soliton flow, and the state of vector multiple solitons occupying the whole cavity. Both the polarization-locked vector solitons (PLVSs) and the polarization-rotating vector solitons (PRVSs) were observed for fundamental soliton and each type of multi-soliton patterns.

[Clinical and biological characteristics of childhood acute myeloid leukemia with EVI1 gene positive expression].

Objective: To study the expression of ecotropic viral integration site (EVI1) gene in childhood acute myeloid leukemia (AML) and the clinical features of EVI1-positive children with AML.

Methods: The clinical data of EVI1-positive children with AML were collected and analyzed. RT-PCR and real-time quantitative PCR were used for qualitative and quantitative analysis of expression of EVI1.

Wave-breaking-free pulse in an all-fiber normal-dispersion Yb-doped fiber laser under dissipative soliton resonance condition.

We reported on the dissipative soliton resonance (DSR) phenomenon in a mode-locked Yb-doped fiber laser by using the nonlinear polarization rotation technique. It was found that the multi-pulse oscillation under high pump power could be circumvented by properly adjusting the polarization controllers, namely, the wave-breaking-free rectangular pulse in DSR region was achieved. As the DSR signature, the pulse duration varied from 8.

Vector dissipative soliton resonance in a fiber laser.

We report on the vector nature of rectangular pulse operating in dissipative soliton resonance (DSR) region in a passively mode-locked fiber laser. Apart from the typical signatures of DSR, the rectangular pulse trapping of two polarization components centered at different wavelengths was observed and they propagated as a group-velocity locked vector soliton. Moreover, the polarization resolved soliton spectra show different spectral distributions.

Dissipative soliton resonance in a passively mode-locked figure-eight fiber laser.

The generation of mode-locked rectangular pulses operating in dissipative soliton resonance (DSR) region is demonstrated in an erbium-doped figure-eight fiber laser with net anomalous dispersion. The duration of the wave-breaking-free rectangular pulse broadens with the increase of pump power. At a maximum pump power of 341 mW, the pulse energy can be up to 3.

[Comparisons of clinical features of chronic aplastic anemia and myelodysplastic syndrome in children].

Objective: This study compared the differences in clinical features between chronic aplastic anemia (CAA) and myelodysplastic syndrome (MDS) in children in order to provide a basis for the differential diagnosis of the two diseases.

Methods: A retrospective study of 23 cases of CAA and 9 cases of MDS from September 2007 to September 2010 was performed. The clinical data including routine blood test results, reticulocyte counts, serum lactate dehydrogenase level, serum ferritin level, cytological examination of bone marrow, bone marrow CD34+ cell counts, bone marrow chromosome and FISH test results were compared between the CAA and MDS groups.

[Therapeutic effects of a combination of high-dose immunoglobulin and cyclosporine A in children with aplastic anemia].

Objective: To evaluate the therapeutic effects of a combined immunotherapy, high-dose immunoglobulin (HDIG) plus cyclosporine A (CsA) plus prednisone (P), in children with aplastic anemia (AA) and to explore the association of peripheral blood lymphocyte subsets, peripheral blood cells and marrow CD34+ cells with therapeutic effects in AA.

Methods: The clinical data of 46 children with AA and who received the combined immunotherapy of HDIG + CsA + P were retrospectively studied.

Results: Of the 46 children with AA, 31 (67.

[Effects of ouabain at low concentrations on growth of leukemia cells].

This study was aimed to investigate the effects of ouabain at low concentrations on growth regulation in various leukemia cell lines and to determine the therapeutic potential of ouabain in leukemia. By using MTT, flow cytometry (FCM), the changes in cell growth and cell cycle of leukemia cell lines were observed after treating with ouabain at low concentrations ( View Article and Find Full Text PDF